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Drug: Methotrexate
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Total 7800 results found since Jan 2013.
Child with acute methotrexate related neurotoxicity: Can diffusion weighted MRI help??
Conclusion Methotrexate can result in reversible neurotoxicity in the form of white matter injury. DWI may be used in early detection of such changes; therefore, it provides a rapid, noninvasive readily available tool by which neurotoxicity can be early detected and treated. It has the potential to alert the oncologist to this event and provide a technique by which neurotoxicity can be monitored.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - August 21, 2015 Category: Nuclear Medicine Source Type: research
Review of Experience of a Statewide Poison Control Center With Pediatric Exposures to Oral Antineoplastic Drugs in the Nonmedical Setting
In this study, exposures to oral antineoplastics were primarily unintentional, asymptomatic, and managed at home. Study limitations include possible reporting bias, inability to objectively confirm exposures, and limited duration of monitoring by the poison control center. In this retrospective review, no significant morbidity or mortality was reported from pediatric exposures to oral antineoplastic drugs in the nonmedical setting.
Source: American Journal of Therapeutics - March 1, 2016 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research
Pharmacological Approach to Managing Childhood-Onset Systemic Lupus Erythematosus During Conception, Pregnancy and Breastfeeding
AbstractPediatric patients often have poor pregnancy outcomes. Systemic lupus erythematosus predominantly impacts women in their second to fourth decade of life, with childhood-onset disease being particularly aggressive. Reproductive issues are an important clinical consideration for pediatric patients with systemic lupus erythematosus (SLE), as maintaining good disease control and planning a pregnancy are important for maternal and fetal outcomes. In this clinical review, we will consider the safety of medications in managing childhood-onset SLE during conception, pregnancy, and breastfeeding. The developing fetus is at ...
Source: Pediatric Drugs - September 3, 2018 Category: Pediatrics Source Type: research
Shedding light on key pharmacological knowledge and strategies for pediatric atopic dermatitis
Expert Rev Clin Pharmacol. 2023 Jan 27. doi: 10.1080/17512433.2023.2173172. Online ahead of print.ABSTRACTINTRODUCTION: Atopic dermatitis (AD) is an inflammatory disease affecting over 20% of the pediatric population, with 85% of cases presenting before the age of five. Recently, therapeutic options in pediatric patients have evolved rapidly, following extensive development in adult treatments.AREAS COVERED: This review will encompass relevant molecular drivers, along with an overlook on treatment modalities in pediatric AD, as well as a summary of pipeline treatments in clinical trials for pediatric patients from PubMed, ...
Source: Pharmacological Reviews - January 27, 2023 Category: Drugs & Pharmacology Authors: Ariana Moreno Yael Renert-Yuval Emma Guttman-Yassky Source Type: research
The impact of chemotherapy shortages on COG and local clinical trials: A report from the Children's Oncology Group
ConclusionsChemotherapy shortages remain widespread across institutions, hinder clinical trials, and may contribute to adverse events in children with cancer. The increased frequency of chemotherapy shortages reported by pharmacists suggests that pharmacist efforts may mitigate negative impact chemotherapy shortages. Over half of pediatric institutions are implementing recommendations to address shortages, such as cross‐institutional collaboration and center‐level guidelines. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - February 19, 2015 Category: Cancer & Oncology Authors: Elizabeth G. Salazar, M. Brooke Bernhardt, Yimei Li, Richard Aplenc, Peter C. Adamson Tags: Research Article Source Type: research
Benefits and Risks of Combining Anti-tumor Necrosis Factor with Immunomodulator Therapy in Pediatric Inflammatory Bowel Disease
Abstract: Since the introduction of anti-tumor necrosis factor (TNF) therapy as treatment of inflammatory bowel disease (IBD), care of pediatric and adult patients with IBD has significantly improved. To further improve treatment efficacy and durability, multiple trials have compared the efficacy of combination therapy, using anti-TNF therapy combined with an immunomodulator (a thiopurine or methotrexate), with that of anti-TNF monotherapy with contradicting results. The safety of combined therapy has been questioned after several reported cases of hepatosplenic T-cell lymphoma in young patients with IBD so treated. Physic...
Source: Inflammatory Bowel Diseases - March 19, 2015 Category: Gastroenterology Tags: Clinical Review Article Source Type: research
Characteristics and treatment of adult-onset linear morphea: A retrospective cohort study of 61 patients at 3 tertiary care centers
To the Editor: Linear morphea (LM) is characterized by linear sclerotic plaques on the limbs or face and scalp. The disorder predominantly manifests in the pediatric population and often results in functional disability or permanent disfigurement. In 2012, the Childhood Arthritis and Rheumatology Research Alliance (CARRA) recommended methotrexate (MTX) with or without systemic corticosteroids (CS) as first-line therapy for pediatric-onset LM.1 However, little is known about adult-onset LM. Thus, we sought to describe the characteristics and treatment of adult-onset LM at 3 tertiary care centers.
Source: Journal of the American Academy of Dermatology - February 17, 2016 Category: Dermatology Authors: Daniel R. Mazori, Natalie A. Wright, Mital Patel, Stephanie W. Liu, Sarika M. Ramachandran, Andrew G. Franks, Ruth Ann Vleugels, Alisa N. Femia Tags: Letter Source Type: research
Anti-Fungal Prophylaxis Using Intermediate Dose Ambisome is Associated with Delayed Methotrexate Clearance in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Pediatric patients with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation (aHSCT) comprise a patient cohort at highest risk of developing disseminated fungal infections. Invasive aspergillosis post-HSCT is associated with unacceptably high mortality in pediatric patients with overall survival of only 15-34%. Hospital construction and excavation further potentiate the risk of fungal related morbidity and mortality in the post-HSCT setting. The current standard of care for anti-fungal prophylaxis for children undergoing aHSCT is the use of triazoles.
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Liora Schultz, Karan Kumar, Suzette Stone, Elizabeth Callard, Jessica Witkowski, Leigh Shinn, Lisa Pinner, Kenneth I. Weinberg, Matthew H. Porteus, Rajni Agarwal, Ami J. Shah, Sandhya Kharbanda Source Type: research
Treatment and biology of pediatric acute lymphoblastic leukemia
This article is protected by copyright. All rights reserved.
Source: Pediatrics International - October 1, 2017 Category: Pediatrics Authors: Motohiro Kato, Atsushi Manabe Tags: Review Article Source Type: research
Cost comparison by treatment arm and center ‐level variations in cost and inpatient days on the phase III high‐risk B acute lymphoblastic leukemia trial AALL0232
Abstract
The Children's Oncology Group (COG) develops and implements multi‐institutional clinical trials with the primary goal of assessing the efficacy and safety profile of treatment regimens for various pediatric cancers. However, the monetary costs of treatment regimens are not measured. AALL0232 was a COG randomized phase III trial for children with acute lymphoblastic leukemia that found that dexamethasone (DEX) was a more effective glucocorticoid than prednisone (PRED) in patients younger than 10 years, but PRED was equally effective and less toxic in older patients. In addition, high‐dose methotrexate (HD‐MT...
Source: Cancer Medicine - December 1, 2017 Category: Cancer & Oncology Authors: Amanda M. DiNofia, Alix E. Seif, Meenakshi Devidas, Yimei Li, Matthew Hall, Yuan ‐Shung V. Huang, Viviane Cahen, Stephen P. Hunger, Naomi J. Winick, William L. Carroll, Brian T. Fisher, Eric C. Larsen, Richard Aplenc Tags: Original Research Source Type: research
How I treat Burkitt lymphoma in children, adolescents, and young adults in sub-Saharan Africa
Burkitt lymphoma (BL) is the most common pediatric cancer in sub-Saharan Africa (SSA), and also occurs frequently among adolescents and young adults (AYAs), often associated with HIV. Treating BL in SSA poses particular challenges. Although highly effective, high-intensity cytotoxic treatments used in resource-rich settings are usually not feasible, and lower-intensity continuous infusion approaches are impractical. In this article, based on evidence from the region, we review management strategies for SSA focused on diagnosis and use of prephase and definitive treatment. Additionally, potentially better approaches for ris...
Source: Blood - July 19, 2018 Category: Hematology Authors: Gopal, S., Gross, T. G. Tags: Pediatric Hematology, How I Treat, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munn é et al.
AbstractA recent study published in Human Reproduction claimed that uterine lavage offers a non-surgical, minimally invasive strategy for the recovery of human embryos from fertile women who do not want or need IVF for medical reasons but who desire preimplantation genetic testing (PGT) for embryos. To prove this hypothesis, the researchers recruited dozens of young Mexican women. The prospective oocyte donors underwent ovarian stimulation to induce the production of multiple mature oocytes. Subsequently, these women were inseminated by donor semen. A few days later, the developing embryos were collected by uterine lavage ...
Source: Journal of Assisted Reproduction and Genetics - October 5, 2020 Category: Reproduction Medicine Source Type: research
