Child with acute methotrexate related neurotoxicity: Can diffusion weighted MRI help??

Conclusion Methotrexate can result in reversible neurotoxicity in the form of white matter injury. DWI may be used in early detection of such changes; therefore, it provides a rapid, noninvasive readily available tool by which neurotoxicity can be early detected and treated. It has the potential to alert the oncologist to this event and provide a technique by which neurotoxicity can be monitored.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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Conclusion:Preliminary data from this Phase 1 trial demonstrate that JWCAR029 can provide significant clinical benefit with manageable AEs in relapsed or refractory adult B-NHL patients. Further data of efficacy, safety, subgroup, PK, serum biomarkers associated with safety and efficacy, anti-drug antibodies, and RNA-sequencing will be presented. Accrual is ongoing.DisclosuresHao: JW Therapeutics: Employment, Equity Ownership. Song: Peking University Cancer Hospital (Beijing Cancer Hospital): Employment. Zhu: Beijing Cancer Hospital: Employment.
Source: Blood - Category: Hematology Authors: Tags: 626. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Prospective Clinical Trials Source Type: research
Conclusion DVST is an uncommon cause of stroke. The appropriate diagnosis is imperative as the treatment for DVS is vastly different from the treatment of arterial stroke. Patients who suffer from DVST have a good prognosis and often achieve complete recovery. This case demonstrates the utility of more invasive endovascular treatments for extreme cases that fail to improve, or worsen, following a trial of conventional care. When thrombolysis and thrombectomy alone were not successful, stenting of an underlying dural sinus stenosis was ultimately required for successful recanalization. Disclosures: D. Leonard: None. A. Ha...
Source: Journal of NeuroInterventional Surgery - Category: Neurosurgery Authors: Tags: Electronic Poster Abstracts Source Type: research
We report a young man who suddenly developed severe headache, disorientation, and aphasia following ingestion of kratom and Adderall. Computed tomography and magnetic resonance imaging of his head revealed foci of vasogenic edema in the posterior occipital lobes, frontal lobes, and brainstem. In addition, he had a small area of hemorrhage in the left posterior occipital lobe. Lumbar puncture revealed an increased number of red blood cells but no other abnormalities. His initial blood pressure was elevated but returned to normal during hospitalization. This case suggests that kratom can cause posterior reversible encephalop...
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
Conclusions:Our patients represent the first case series of SMART syndrome in a single institution. Our cases share similarities to the prior reports in the literature and highlights the clinical and MRI triad of acute onset headaches, neurological deficits and MRI findings of transient contrast enhancement of the cortex with white matter sparing in a previous radiation field.Disclosure: Dr. rauf has nothing to disclose. Dr. Boulter has nothing to disclose. Dr. Imitola has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Neurologic Complications of Cancer Source Type: research
Conclusions:Stroke-like migraine attacks are difficult to treat and the pathophysiology is unknown. With more sophisticated imaging techniques, a better understanding of this phenomenon will aid in the treatment and prophylaxis of the syndrome with a goal of improving quality of life for this small but slowly growing population.Disclosure: Dr. New has nothing to disclose. Dr. Mirza has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Neuro-oncology: Gliomas I Source Type: research
Conclusions:Epileptic reversible Anton’s syndrome is rarely seen with a handful of reported cases. We report a patient with CLL that developed PRES and seizures as a complication of chemotherapy and Anton’s syndrome from documented occipital PLEDs that resolved with control of electrographic seizure activity. Occipital PLEDS should point toward the hope of reversibility of cortical blindness from PRES related seizures and EEG should be more frequently utilized in PRES as it may detect sub-clinical seizures requiring more aggressive medical treatment.Disclosure: Dr. Siddiqui has nothing to disclose. Dr. Khandker...
Source: Neurology - Category: Neurology Authors: Tags: Child Neurology and Epilepsy/Clinical Neurophysiology (EEG) ePoster Session Source Type: research
CONCLUSION:Infusion of D2C7-IT via CED is safe thus far and encouraging efficacy results are observed. Enrollment is ongoing.
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: ADULT CLINICAL TRIALS (IMMUNOLOGICAL) Source Type: research
Conclusion:PT re-irradiation of large-volume rGBM showed to be feasible and safe even with concomitant chemotherapy administration. Despite the small number of patients and the retrospective nature of the study PFS and OS rates were promising and deserve further evaluation in a larger pts sample.
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: P08 Glioblastom and Anaplastic gliomas Source Type: research
Publication date: Available online 11 June 2016 Source:Gynecologic Oncology Reports Author(s): Kayo Inoue, Hiroshi Tsubamoto, Yusuke Tomogane, Mariko Kamihigashi, Hiroaki Shibahara A 48-year-old woman underwent a total abdominal hysterectomy after preoperative diagnosis of multiple uterine leiomyomas. The histopathological diagnosis was leiomyosarcoma (LMS). After 47months, multiple lung metastases were detected and resected. The patient was also diagnosed with pelvic bone metastasis and received six cycles of adjuvant chemotherapy with gemcitabine plus docetaxel and local radiation therapy to control the pain. Seve...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
CONCLUSIONS: Dural metastases present with a variety of clinical symptoms. They occur in several types of cancer, often in advanced conditions. For appropriate diagnosis, biopsy is needed. Treatment options include surgical approaches or chemotherapy but usually radiotherapy is preferred.Disclosure: Dr. Ackerl has nothing to disclose. Dr. Loyoddin has nothing to disclose. Dr. Barbara has nothing to disclose. Dr. Grisold has nothing to disclose. Dr. Surboeck has nothing to disclose. Dr. Grisold has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Neuro-oncology: Neurologic Complications of Cancer Source Type: research
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