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Total 9822 results found since Jan 2013.

Medical care of type 2 diabetes mellitus in light of international and national recommendations: a retrospective analysis.
CONCLUSIONS: In the majority of unselected T2Dm patients admitted to our hospital, metabolic control was suboptimal. Implementation of treatment recommendations by both general practitioners and hospitals should be improved. PMID: 24163110 [PubMed - in process]
Source: Swiss Medical Weekly - November 2, 2013 Category: Journals (General) Authors: Burgmann K, Fatio SA, Jordi B, Rutishauser J Tags: Swiss Med Wkly Source Type: research

Childhood Obesity and Insulin Resistance: How Should It Be Managed?
Opinion statement Concomitant with the rise in global pediatric obesity in the past decades, there has been a significant increase in the number of children and adolescents with clinical signs of insulin resistance. Given insulin resistance is the important link between obesity and the associated metabolic abnormalities and cardiovascular risk, clinicians should be aware of high risk groups and treatment options. As there is no universally accepted biochemical definition of insulin resistance in children and adolescents, identification and diagnosis of insulin resistance usually relies on clinical features such a...
Source: Current Treatment Options in Cardiovascular Medicine - October 9, 2014 Category: Cardiology Source Type: research

Top medicine articles for November 2014
A collection of some interesting medical articles published recently:'To Burn Off Calories in This Soda, Walk 5 Miles' - new label http://buff.ly/1vzbCKHTwo new medications for IPF: Pirfenidone (Esbriet) affects scarring, Nintedanib (Ofev) is a kinase inhibitor http://buff.ly/1psam6m80% of people have at least 1 distressing symptom in a given month, yet fewer than 1 in 4 persons sees a doctor. At least one third of common symptoms do not have a clear-cut, disease-based explanation. History and physical examination alone contribute 73% to 94% of the diagnostic information. The patient's history alone yields 75% of the diagn...
Source: Clinical Cases and Images - November 17, 2014 Category: Journals (General) Tags: Health News of the Day Source Type: news

Adherence to Metformin, Statins, and ACE/ARBs Within the Diabetes Health Plan (DHP)
Conclusions The Diabetes Health Plan, an innovative health plan that combines reduced cost-sharing and disease management with an up-front requirement of enrollee participation in his or her own health care, is associated with a modest improvement in medication adherence at 12 months.
Source: Journal of General Internal Medicine - May 6, 2015 Category: Internal Medicine Source Type: research

Extemporaneous Formulations of Metformin for Pediatric Endocrinology: Physicochemical Integrity, Cytotoxicity of Sweeteners, and Quantitation of Plasma Levels.
Abstract PURPOSE: In response to the lack of pediatric formulations of metformin to control type 2 diabetes mellitus, hyperinsulinemic obesity, and dyslipidemias, we developed liquid formulations of metformin by dissolving 3 generic brands of 500-mg metformin(*)(†)(‡) tablets in water sweetened with sucralose. The physicochemical stabilities of these drugs were assessed and compared with those of formulations made with the innovative brand of metformin.(∥) A method to measure metformin plasma levels was proposed and then tested in 2 healthy subjects. This method may be useful to survey treatment compliance i...
Source: Clinical Therapeutics - June 16, 2015 Category: Drugs & Pharmacology Authors: Alemón-Medina R, Chávez-Pacheco JL, Rivera-Espinosa L, Ramírez-Mendiola B, García-Álvarez R, Sámano-Salazar C, Manuel Dávila-Borja V Tags: Clin Ther Source Type: research

Top 20 Research Studies of 2014 for Primary Care Physicians.
This article, the fourth installment in this annual series, summarizes the 20 POEMs based on original research studies judged to have the greatest impact on practice for family physicians. Key studies for this year include advice on symptomatic management and prognosis for acute respiratory infections; a novel and effective strengthening treatment for plantar fasciitis; a study showing that varenicline plus nicotine replacement is more effective than varenicline alone; a network meta-analysis concluding that angiotensin-converting enzyme inhibitors are preferred over angiotensin II receptor blockers; the clear benefits of ...
Source: American Family Physician - September 1, 2015 Category: Primary Care Authors: Ebell MH, Grad R Tags: Am Fam Physician Source Type: research

Abstract A70: Targeting pediatric bone sarcoma stem cell with metabolic inhibitors
Our project tests whether metabolic inhibitors are able to target putative sarcoma stem cells in osteosarcoma and Ewing sarcoma. The cure rate for the two most common bone sarcomas affecting children and adolescents, osteosarcoma and Ewing sarcoma, has plateaued around 70% over the past twenty years, and the cure rate for patients with metastatic bone sarcomas has not significantly improved over 20% in several decades. The subpopulation of cells in these tumors referred to as sarcoma stem cells are thought to be responsible for resistance to current therapies, relapses and metastases. To date therapies targeting the sarcom...
Source: Molecular Cancer Research - January 15, 2016 Category: Cancer & Oncology Authors: Trucco, M., Rainsusso, N., Techavichit, P., Bernardi, R., Shuck, R., Satterfield, L., Allen-Rhoades, W., Donehower, L., Loeb, D., Yustein, J. Tags: Therapeutic Targets From Cancer: Poster Presentations - Proffered Abstracts Source Type: research

Treatment of diabetes in children.
Authors: Gao YQ, Gao M, Xue Y Abstract Type 1 diabetes mellitus (T1D) and type 2 diabetes (T2D) mellitus are on the increase in children and adolescents. An increase in T2D is linked to the increasing rates of obesity in children. Usually, in both children and adults, T1D is treated with insulin while T2D is treated with metformin. There are other classes of drugs that are under assessment for their safety and efficacy in relation to pediatric patients. Most of these new drugs, however, have not been studied in children. Thus, the repertoire of drugs that are available to treat diabetes in children is limited. In t...
Source: Experimental and Therapeutic Medicine - April 15, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice
Fanconi anemia (FA) is an inherited bone marrow failure disorder associated with a high incidence of leukemia and solid tumors. Bone marrow transplantation is currently the only curative therapy for the hematopoietic complications of this disorder. However, long-term morbidity and mortality remain very high, and new therapeutics are badly needed. Here we show that the widely used diabetes drug metformin improves hematopoiesis and delays tumor formation in Fancd2–/– mice. Metformin is the first compound reported to improve both of these FA phenotypes. Importantly, the beneficial effects are specific to FA mice a...
Source: Blood - December 14, 2016 Category: Hematology Authors: Zhang, Q.-S., Tang, W., Deater, M., Phan, N., Marcogliese, A. N., Li, H., Al-Dhalimy, M., Major, A., Olson, S., Monnat, R. J., Grompe, M. Tags: Hematopoiesis and Stem Cells, Pediatric Hematology, Free Research Articles, Myeloid Neoplasia, Red Cells, Iron, and Erythropoiesis Source Type: research

Comparison of use of diabetic medication and clinical guidelines in four Nordic countries.
CONCLUSIONS: All guidelines stress regular and comprehensive diabetes care. Danish and Finnish guidelines strongly underline the importance of individualized glycemic targets. All guidelines recommend metformin as the initial oral antihyperglycemic drug. In relation to recommended second line drug therapy and initial insulin type for patients with T2D, the guidelines vary largely between the four countries. PMID: 26890317 [PubMed - indexed for MEDLINE]
Source: Annals of Medicine - January 1, 2017 Category: Internal Medicine Tags: Ann Med Source Type: research

Healthcare freebies that can make you, and your wallet, feel a little better
“Take the cookies, bring them home to the kids!” Craig always insists, as he pops a few into my lunch bag. It’s a heartwarming gesture that I love about his Sarasota deli — in addition to the killer turkey on whole wheat. You may not be surprised when local businesses throw in a freebie; they often go the extra mile to thank customers. But you may be surprised to know that there are lots of free things out there that can help your health. Okay, not cookies, but things with real value when it comes to improving everything from chronic disease to diet and fitness. Free prescription drugs Some stores (such as Publix a...
Source: Harvard Health Blog - November 27, 2017 Category: Consumer Health News Authors: Heidi Godman Tags: Health Health care Managing your health care Source Type: blogs

Can Money Buy You Longevity And Health?
Better treatment options, dietary conditions and (perhaps) less stress could make the life of the rich also healthier. However, when it comes to longevity and aging, do they really have better chances? Can the upper 0.1 percent secure their health for long decades or even reverse the process of growing old? Could society somehow also benefit from the quest of the richest for longevity? Are health and longevity on the shopping list? You can have an awful lot of things with money. For a starter, you can buy ice cream or Nutella, which are synonymous to self-love, so the Beatles was only partly right in singing that you can...
Source: The Medical Futurist - November 22, 2018 Category: Information Technology Authors: nora Tags: Bioethics Cyborgization Future of Medicine Medical Professionals Patients Policy Makers age aging aging research blood eternal life genetics immortality Innovation life sciences longevity silicon valley stem cell Source Type: blogs

Patterns of Diabetes Screening and Prediabetes Treatment during Office Visits in the US
Conclusions: The prevalence of diabetes screening during office visits remained lower than 15% between 2012 and 2015 in the United States. Physicians primarily prescribe lifestyle modifications, including a healthy diet and exercise, with metformin being used in some cases for the prevention of diabetes.
Source: Journal of the American Board of Family Medicine - March 7, 2019 Category: Primary Care Authors: Shealy, K. M., Wu, J., Waites, J., Taylor, N. A., Blair Sarbacker, G. Tags: Original Research Source Type: research

Assessment of the Fetal Myocardial Performance Index in Well-Controlled Gestational Diabetics and to Determine Whether It Is Predictive of Adverse Perinatal Outcome
This study was aimed at determining if the myocardial performance index (MPI) is altered in well-controlled gestational diabetics and if so whether it is predictive of adverse perinatal outcome. In a prospective cross-sectional study, 54 consecutive women with well-controlled gestational diabetes controlled on insulin or metformin in the third trimester were recruited and matched with 54 women with normal pregnancies (control group). Using Doppler echocardiography, the MPI was calculated. Sonographic biophysical and placental resistance Doppler markers in both groups were also determined. An abnormal outcome was defined as...
Source: Pediatric Cardiology - July 18, 2019 Category: Cardiology Source Type: research

Non-alcoholic Fatty Liver Disease and Diabetes Mellitus.
Authors: Khneizer G, Rizvi S, Gawrieh S Abstract Nonalcoholic fatty liver disease (NAFLD) has emerged as the leading liver disease globally. NAFLD patients can have a progressive phenotype, non-alcoholic steatohepatitis (NASH) that could lead to cirrhosis, liver failure and cancer. There is a close bi-directional relationship between NAFLD and type 2 diabetes mellitus (T2DM); NAFLD increases the risk for T2DM and its complications whereas T2DM increases the severity of NAFLD and its complications. The large global impact of NAFLD and T2DM on healthcare systems requires a paradigm shift from specialty care to early ...
Source: Advances in Experimental Medicine and Biology - May 21, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research