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Drug: Acetic Acid
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< em > Stauntonia hexaphylla < /em > leaf extract (YRA-1909) suppresses inflammation by modulating Akt/NF- κB signaling in lipopolysaccharide-activated peritoneal macrophages and rodent models of inflammation
CONCLUSIONS: S. hexaphylla leaf extract YRA-1909 had anti-inflammatory activity in vitro and in vivo that involves modulation of Akt/NF-κB signaling. Thus, YRA-1909 is safe and effective for the treatment of inflammation.PMID:34776829 | PMC:PMC8559446 | DOI:10.29219/fnr.v65.7666
Source: Food and Nutrition Research - November 15, 2021 Category: Nutrition Authors: Jaeyong Kim Gyuok Lee Huwon Kang Ji-Seok Yoo Yongnam Lee Hak-Sung Lee Chul-Yung Choi Source Type: research
Primary Tumor Suppression and Systemic Immune Activation of Macrophages through the Sting Pathway in Metastatic Skin Tumor
CONCLUSION: The abscopal effect of DMXAA treatment on the skin strongly reduced the spread of EML4-ALK lung cancer and CT26 colon cancer through the STING pathway and induced the presentation of antigens.PMID:34913283 | PMC:PMC8688365 | DOI:10.3349/ymj.2022.63.1.42
Source: Yonsei Medical Journal - December 16, 2021 Category: Universities & Medical Training Authors: Chun-Bong Synn Dong Kwon Kim Jae Hwan Kim Youngseon Byeon Young Seob Kim Mi Ran Yun Ji Min Lee Wongeun Lee Eun Ji Lee Seul Lee You-Won Lee Doo Jae Lee Hyun-Woo Kim Chang Gon Kim Min Hee Hong June Dong Park Sun Min Lim Kyoung-Ho Pyo Source Type: research
Application of Porcine Kidney-Derived Extracellular Matrix as Coating, Hydrogel, and Scaffold Material for Renal Proximal Tubular Epithelial Cell
CONCLUSIONS: We concluded that renal ECM can be a suitable material for RPTE cell culture and usage. More practically, the coated renal ECM stimulates RPTE cell proliferation, and the hydrogel and scaffold of renal ECM provide useful 3D culture niche and cell delivery vehicles maintaining renal cell properties.PMID:35127940 | PMC:PMC8816548 | DOI:10.1155/2022/2220641
Source: Cell Research - February 7, 2022 Category: Cytology Authors: Eun Hye Lee So Young Chun Bo Hyun Yoon Hyun Tae Kim Jae-Wook Chung Jun Nyung Lee Yun-Sok Ha Tae Gyun Kwon Kyeong-Hyeon Byeon Bum Soo Kim Source Type: research
Analytical Method Validation for Estimation of Neurotransmitters (Biogenic Monoamines) from Cerebrospinal Fluid Using High Performance Liquid Chromatography
Indian J Clin Biochem. 2022 Jan;37(1):85-92. doi: 10.1007/s12291-020-00949-8. Epub 2021 Jan 6.ABSTRACTBiogenic amine neurotransmitters such as serotonin and dopamine are essential for signaling in both central and peripheral nervous system. Their metabolism is a multistep pathway and any defect in this results in alteration in metabolites of serotonin 5-Hydroxyindole acetic acid (5HIAA) and dopamine homovanillic acid (HVA) and 3-O-Methyl Dopa (3-OMD). Estimation of these metabolites in cerebrospinal fluid (CSF) assists in diagnosis of neurotransmitter defects. Their estimation is technically demanding and is currently avai...
Source: Clinical Biochemistry - February 7, 2022 Category: Biochemistry Authors: Rohan V Lokhande Ganesh R Bhagure Alpa J Dherai Prasad R Naik Vrajesh P Udani Neelu A Desai Tester F Ashavaid Source Type: research
Application of Porcine Kidney-Derived Extracellular Matrix as Coating, Hydrogel, and Scaffold Material for Renal Proximal Tubular Epithelial Cell
CONCLUSIONS: We concluded that renal ECM can be a suitable material for RPTE cell culture and usage. More practically, the coated renal ECM stimulates RPTE cell proliferation, and the hydrogel and scaffold of renal ECM provide useful 3D culture niche and cell delivery vehicles maintaining renal cell properties.PMID:35127940 | PMC:PMC8816548 | DOI:10.1155/2022/2220641
Source: Biomed Res - February 7, 2022 Category: Research Authors: Eun Hye Lee So Young Chun Bo Hyun Yoon Hyun Tae Kim Jae-Wook Chung Jun Nyung Lee Yun-Sok Ha Tae Gyun Kwon Kyeong-Hyeon Byeon Bum Soo Kim Source Type: research
Effects of Whole Brown Bean and Its Isolated Fiber Fraction on Plasma Lipid Profile, Atherosclerosis, Gut Microbiota, and Microbiota-Dependent Metabolites in Apoe(-/-) Mice
This study investigated and compared the effects of whole brown beans and an isolated bean dietary fiber fraction on the plasma lipid profile, atherosclerotic plaque amount, gut microbiota, and microbiota-dependent metabolites (cecal short-chain fatty acids (SCFAs) and plasma methylamines) in Apoe-/- mice fed high fat diets for 10.5 weeks. The results showed that both whole bean and the isolated fiber fraction had a tendency to lower atherosclerotic plaque amount, but not plasma lipid concentration. The whole bean diet led to a significantly higher diversity of gut microbiota compared with the high fat diet. Both bean diet...
Source: Atherosclerosis - March 10, 2022 Category: Cardiology Authors: Jiyun Liu Mohammed E Hefni Cornelia M Witth öft Maria Bergstr öm Stephen Burleigh Margareta Nyman Frida H ållenius Source Type: research
L-cysteine modulates visceral nociception mediated by the Ca < sub > V < /sub > 2.3 R-type calcium channels
Pflugers Arch. 2022 Apr;474(4):435-445. doi: 10.1007/s00424-022-02674-y. Epub 2022 Mar 10.ABSTRACTCaV2.3 channels are subthreshold voltage-gated calcium channels that play crucial roles in neurotransmitter release and regulation of membrane excitability, yet modulation of these channels with endogenous molecules and their role in pain processing is not well studied. Here, we hypothesized that an endogenous amino acid l-cysteine could be a modulator of these channels and may affect pain processing in mice. To test this hypothesis, we employed conventional patch-clamp technique in the whole-cell configuration using recombina...
Source: Pflugers Archiv : European Journal of Physiology - March 10, 2022 Category: Physiology Authors: Seyed Mohammadreza Ghodsi MacKenzie Walz Toni Schneider Slobodan M Todorovic Source Type: research
Optimized Collagen Extraction Process to Obtain High Purity and Large Quantity of Collagen from Human Perirenal Adipose Tissue
Biomed Res Int. 2022 Mar 31;2022:3628543. doi: 10.1155/2022/3628543. eCollection 2022.ABSTRACTThere is growing interest in human adipose tissue-derived collagen as a replacement for animal origin or synthetic materials. Large amounts of adipose tissues around the kidney are being discarded after kidney surgery; thus, we planned to use this tissue as a potentially ideal source of human collagen. Optimization of the collagen extraction process can contribute to the quality, quantity, supply, and cost of collagen production. To extract highly purified and concentrated collagen from human perirenal adipose tissue, we developed...
Source: Biomed Res - April 11, 2022 Category: Research Authors: Eun Hye Lee So Young Chun Jun Nyung Lee Bo Hyun Yoon Jae-Wook Chung Man-Hoon Han Tae Gyun Kwon Yun-Sok Ha Bum Soo Kim Source Type: research
Using extracellular vesicles derived from human umbilical cord mesenchymal stem cells for a topical coating promotes oral mucositis healing in rats
CONCLUSIONS: Our results showed for the first time that coating hUC-MSC-EVs topically can promote healing of OM because it may inhibit the activation of the NF-κB signaling pathway.PMID:35434027 | PMC:PMC9011321 | DOI:10.21037/atm-22-767
Source: Cancer Control - April 18, 2022 Category: Cancer & Oncology Authors: Zhe Gao Lixun Guan Zhanxiang Liu Fei Yan Shu Fang Xiangmei Zhang Chunji Gao Source Type: research
