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Drug: Acetazolamide
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Total 51 results found since Jan 2013.
White Matter Cerebrovascular Reactivity: Effects of Microangiopathy and Proximal Occlusions on the Dynamic BOLD Response
CONCLUSION: Our results suggest additive effects of microvascular and macrovascular disease upon white matter CVR, but with greater overall effects relating to macrovascular SOD than to apparent microangiopathy. Dynamic ACZ-BOLD presents a promising path towards a quantitative stroke risk imaging biomarker.BACKGROUND: Cerebral white matter (WM) microangiopathy manifests as sporadic or sometimes confluent high intensity lesions in MR imaging with T2-weighting, and bears known associations with stroke, cognitive disability, depression and other neurological disorders 1-5 . Deep white matter is particularly susceptible to isc...
Source: Atherosclerosis - July 3, 2023 Category: Cardiology Authors: J Michael Gee Xiuyuan Wang Siddhant Dogra Jelle Veraart Koto Ishida Seena Dehkharghani Source Type: research
Cerebrovascular Reserve (CVR) and Stages of Hemodynamic Compromise
Adv Exp Med Biol. 2022;1395:363-366. doi: 10.1007/978-3-031-14190-4_59.ABSTRACTThe concept of hemodynamic compromise (HC) is used to detect brain regions under ischemic stress by impaired ability to dilate in response to a vasodilatory challenge for cerebrovascular reserve (CVR). The vasodilatory challenges are either inhaled CO2 or a carbonic anhydrase inhibitor acetazolamide (AZ) with measurements of cerebral blood flow (CBF) before and during the challenge. The rationale for CVR is that the brain under ischemic stress is vasodilated and the increase in CBF is attenuated. However, regional oxygen extraction fraction (OEF...
Source: Advances in Experimental Medicine and Biology - December 17, 2022 Category: Research Authors: Edwin M Nemoto Howard Yonas Source Type: research
Disturbed Sleep is Not Good for the Heart: A Narrative Review
Curr Cardiol Rev. 2022 Nov 30. doi: 10.2174/1573403X19666221130100141. Online ahead of print.ABSTRACTSleep-related breathing disorders, including obstructive sleep apnea (OSA) and central sleep apnea (CSA), have a major impact on cardiovascular function. It has shown an association with hypertension, coronary artery disease, cardiac arrhythmias, sudden cardiac death, and congestive heart failure (CHF). This review focuses on highlighting the relationship between sleep apnea and CHF. We discuss the underlying pathophysiology which involves the mechanical, neurohormonal, and inflammatory mechanisms; in addition, the similari...
Source: Current Cardiology Reviews - December 1, 2022 Category: Cardiology Authors: Meet Patel Harshani Yarlagadda Shubekshya Upadhyay Ritesh Neupane Umer Qureshi Joseph D Raco Rahul Jain Rohit Jain Source Type: research
Evaluation of Cerebrovascular Reactivity and Vessel-Wall Imaging in Patients With Prior COVID-19: A Prospective Case-Control MRI Study
Conclusion: SARS-CoV2 infection is associated with chronic CVR impairment. The mechanistic basis is unknown from this study. Clinical Impact: Future studies are needed to determine the clinical implications arising from SARS-CoV2-associated CVR impairment.PMID:36000667 | DOI:10.2214/AJR.22.28267
Source: Atherosclerosis - August 24, 2022 Category: Cardiology Authors: Andrew L Callen Jody Tanabe Ashesh A Thaker Rebecca Pollard Brian Sauer William Jones Jack Pattee Brandon Steach Vincent Timpone Source Type: research
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus
ConclusionsAZE lowers ICP directly via its ability to reduce the choroid plexus CSF secretion, irrespective of mode of drug administration.
Source: Fluids and Barriers of the CNS - June 29, 2022 Category: Neuroscience Source Type: research
Hemodynamic evaluation of patients with Moyamoya Angiopathy: comparison of resting-state fMRI to breath-hold fMRI and 15Owater PET
ConclusionThe present analysis indicates that rs-fMRI might be a promising non-invasive method with almost no patient cooperation needed to evaluate the CVR. Further prospective studies are required.
Source: Neuroradiology - February 17, 2022 Category: Radiology Source Type: research
Assessment of Impaired Cerebrovascular Reactivity in Chronic Cerebral Ischemia using Intravoxel Incoherent Motion Magnetic Resonance Imaging
The severity of chronic cerebral ischemia can be assessed using cerebrovascular reactivity (CVR) to acetazolamide (ACZ) challenge, which is measured by single-photon emission computed tomography (SPECT); however, this is an invasive method. We investigated whether intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) can assess impaired CVR in preoperative patients with chronic cerebral ischemia and compared it to SPECT-CVR.
Source: Journal of Stroke and Cerebrovascular Diseases - September 23, 2021 Category: Neurology Authors: Ikuko Uwano, Masakazu Kobayashi, Kengo Setta, Kuniaki Ogasawara, Fumio Yamashita, Futoshi Mori, Tsuyoshi Matsuda, Makoto Sasaki Source Type: research
CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients
Eur J Paediatr Neurol. 2021 May 26;33:75-85. doi: 10.1016/j.ejpn.2021.05.010. Online ahead of print.ABSTRACTCACNA1A pathogenic mutations are involved in various neurological phenotypes including episodic ataxia (EA2), spinocerebellar ataxia (SCA6), and familial hemiplegic migraine (FHM1). Epilepsy is poorly documented. We studied 18 patients (10 males) carrying de novo or inherited CACNA1A mutations, with median age of 2,5 years at epilepsy onset. Eight mutations were novel. Two variants known leading to gain of function (GOF) were found in 5 patients. Five other patients had non-sense variants leading to loss of function ...
Source: European Journal of Paediatric Neurology - June 8, 2021 Category: Neurology Authors: Marie Le Roux Magalie Barth Sophie Gueden Patrick Desbordes de Cepoy Alec Aeby Catheline Vilain Edouard Hirsch Anne de Saint Martin Vincent des Portes Ga ëtan Lesca Audrey Riquet Laurence Chaton Nathalie Villeneuve Laurent Villard Claude Cances Luc Valto Source Type: research
COVID-19 and Cerebrovascular Diseases: A Systematic Review and Perspectives for Stroke Management
Conclusion: Cerebrovascular events are relatively common findings in COVID-19 infection, and they could have a multifactorial etiology. More accurate and prospective data are needed to better understand the impact of cerebrovascular events in COVID-19 infection.
Source: Frontiers in Neurology - November 5, 2020 Category: Neurology Source Type: research
