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Drug: Acetazolamide
Procedure: Perfusion

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Total 16 results found since Jan 2013.

Obstructive carotid and/or intracranial artery disease rarely affects the incidence of haemodynamic ischaemic stroke during cardiac surgery: a study on brain perfusion single-photon emission computed tomography with acetazolamide ADULT CARDIAC
CONCLUSIONS It is unusual for CIAD to affect the incidence of haemodynamic ischaemic stroke during cardiac surgery. Brain perfusion SPECT with acetazolamide is effective for narrowing down patients at high risk of ischaemic stroke during cardiac surgery. Meanwhile, the application of brain perfusion single-photon emission tomography should be confined only to patients with obstructive CIAD because it is an expensive examination tool.
Source: European Journal of Cardio-Thoracic Surgery - October 16, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Imasaka, K.-i., Yasaka, M., Tayama, E., Tomita, Y. Tags: Cardiac - other ADULT CARDIAC Source Type: research

Quantitative HO-PET in Pediatric Moyamoya Disease: Evaluating Perfusion before and after Cerebral Revascularization
Moyamoya disease (MMD) is an idiopathic intracranial angiopathy with a progressive spontaneous occlusion of the circle of Willis resulting in repeated ischemia if not diagnosed and treated early, especially in children. Prevention of stroke is achieved by revascularization of the affected cerebral regions. Functional imaging techniques such as H2[15O]-Positron emission tomography (PET) allow quantification of cerebral perfusion/blood flow (CBF) and in particular cerebrovascular response after acetazolamide (AZA) challenge.
Source: Journal of Stroke and Cerebrovascular Diseases - March 24, 2015 Category: Neurology Authors: Felix P. Kuhn, Geoff Warnock, Thomas Schweingruber, Michael Sommerauer, Alfred Buck, Nadia Khan Source Type: research

White Matter Cerebrovascular Reactivity: Effects of Microangiopathy and Proximal Occlusions on the Dynamic BOLD Response
CONCLUSION: Our results suggest additive effects of microvascular and macrovascular disease upon white matter CVR, but with greater overall effects relating to macrovascular SOD than to apparent microangiopathy. Dynamic ACZ-BOLD presents a promising path towards a quantitative stroke risk imaging biomarker.BACKGROUND: Cerebral white matter (WM) microangiopathy manifests as sporadic or sometimes confluent high intensity lesions in MR imaging with T2-weighting, and bears known associations with stroke, cognitive disability, depression and other neurological disorders 1-5 . Deep white matter is particularly susceptible to isc...
Source: Atherosclerosis - July 3, 2023 Category: Cardiology Authors: J Michael Gee Xiuyuan Wang Siddhant Dogra Jelle Veraart Koto Ishida Seena Dehkharghani Source Type: research

Occlusive radiation cerebral vasculopathy implies medical complexity: a case report
ConclusionLate-onset occlusive radiation vasculopathy is a potentially severe iatrogenic manifestation of radiotherapy that requires a high index of suspicion as an etiology of stroke in young population, especially those with coexistent meningioma that might be a strong indicator for occlusive radiation vasculopathy as the stroke culprit. We reviewed the available literature to better understand the pathogenesis, clinical presentation, and treatment options of occlusive radiation vasculopathy. Applying perfusion studies with acetazolamide measures the cerebrovascular reserve in patients with occlusive radiation vasculopat...
Source: Journal of Medical Case Reports - June 2, 2019 Category: General Medicine Source Type: research

Assessment of cerebral blood perfusion changes after neurorehabilitation therapy in patients with middle cerebral artery infarction: An acetazolamide ‐challenged SPECT study
Abstract Stroke is a leading cause of death and disability worldwide. Although neuroimaging has been used to examine brain changes related to recovery from stroke, cerebral perfusion changes after rehabilitation have yet to be elucidated. The aim of this study was to evaluate the regional cerebral blood flow (rCBF) changes and their associations with gross motor functions after neurorehabilitation therapy in stroke patients. A total of 7 patients with middle cerebral artery (MCA) infarction received conventional neurorehabilitation therapy twice per day for 4‐6 weeks on admission. Brain perfusion images were acquired bef...
Source: International Journal of Imaging Systems and Technology - November 11, 2017 Category: Radiology Authors: Kyung ‐Sool Jang, Jooyeon J. Im, Yong‐An Chung, Sung‐Woo Chung, Hyeonseok S. Jeong, Min‐Wook Kim Tags: RESEARCH ARTICLE Source Type: research

123I-IMP-SPECT in a Patient with Cerebral Proliferative Angiopathy: A Case Report
We describe cerebral perfusion abnormalities in a patient with CPA by using N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography (123I-IMP-SPECT) and perfusion-weighted magnetic resonance imaging. The patient, a 13-year-old boy, had reversible focal neurological deficits unrelated to cerebral hemorrhage. 123I-IMP-SPECT at resting state showed preserved uptake within the vascular lesion, yet lower uptake in the area adjacent to the lesion. In addition, acetazolamide-stressed 123I-IMP-SPECT exhibited severely impaired cerebrovascular reactivity over the affected hemisphere, suggesting that his foca...
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Tomomi Kimiwada, Toshiaki Hayashi, Reizo Shirane, Teiji Tominaga Tags: Case Reports Source Type: research

Prediction of Cerebrovascular Reserve Capacity by Computed Tomography Perfusion Using 320-Row Computed Tomography
Acetazolamide loading has been the “gold standard” for evaluating cerebrovascular reserve capacity (CVRC). However, life-threatening side effects of acetazolamide have recently been reported. The aim of the study was to identify alternative methods for evaluating CVRC.
Source: Journal of Stroke and Cerebrovascular Diseases - March 25, 2015 Category: Neurology Authors: Satoshi Takahashi, Yoshio Tanizaki, Hiroaki Kimura, Kazunori Akaji, Tadashige Kano, Kentaro Suzuki, Youhei Takayama, Takao Kanzawa, Satoka Shidoh, Masaki Nakazawa, Kazunari Yoshida, Ban Mihara Source Type: research

Leptomeningeal Enhancement on Magnetic Resonance Imaging as a Predictor of Hemodynamic Insufficiency
The objective of this study was to evaluate the value of leptomeningeal enhancement on magnetic resonance imaging in relation to relative cerebral blood flow (rCBF) and cerebrovascular reserve. Methods: A retrospective analysis was performed for 31 patients with internal carotid artery or proximal middle cerebral artery occlusion without primary collateral flow, who underwent enhanced T1-weighted magnetic resonance imaging and acetazolamide-challenged perfusion computed tomography. They were graded into 3 groups in leptomeningeal enhancement on T1-weighted imaging. The rCBF and the percentage change of cerebral blood flow ...
Source: Journal of Computer Assisted Tomography - May 1, 2015 Category: Radiology Tags: Neuroradiology Source Type: research

Arterial Spin Labeling Perfusion Magnetic Resonance Image with Dual Postlabeling Delay: A Correlative Study with Acetazolamide Loading I-Iodoamphetamine Single-Photon Emission Computed Tomography
Perfusion magnetic resonance image with arterial spin labeling (ASL) provides a completely noninvasive measurement of cerebral blood flow (CBF). However, arterial transient times can have a marked effect on the ASL signal. For example, a single postlabeling delay (PLD) of 1.5 seconds underestimates the slowly streaming collateral pathways that maintain the cerebrovascular reserve (CVR). To overcome this limitation, we developed a dual PLD method.
Source: Journal of Stroke and Cerebrovascular Diseases - September 16, 2015 Category: Neurology Authors: Sei Haga, Takato Morioka, Takafumi Shimogawa, Tomoaki Akiyama, Kei Murao, Yuka Kanazawa, Tetsuro Sayama, Shuji Arakawa Source Type: research

Hemodynamic Significance of Internal Carotid or Middle Cerebral Artery Stenosis Detected on Magnetic Resonance Angiography.
CONCLUSION: A considerable proportion of ICA-MCA stenosis detected on MRA does not cause CVR impairment despite a fair correlation between them. Thus, hemodynamic state needs to be assessed for evaluating significance of stenosis, particularly in asymptomatic patients. PMID: 26446655 [PubMed - in process]
Source: Yonsei Medical Journal - October 9, 2015 Category: Universities & Medical Training Authors: Seo HJ, Pagsisihan JR, Paeng JC, Choi SH, Cheon GJ, Chung JK, Lee DS, Kang KW Tags: Yonsei Med J Source Type: research

Assessment of Hemodynamic Compromise Using Computed Tomography Perfusion in Combination with 123I-IMP Single-Photon Emission Computed Tomography without Acetazolamide Challenge Test
In this study, we investigated whether CT perfusion in combination with resting state 123I-IMP SPECT could be used instead of the acetazolamide challenge test to evaluate hemodynamic compromise in patients with atherosclerotic occlusive disease.
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2016 Category: Neurology Authors: Atsumu Hashimoto, Takeshi Mikami, Katsuya Komatsu, Shouhei Noshiro, Tohru Hirano, Masahiko Wanibuchi, Nobuhiro Mikuni Source Type: research

Hypercapnic BOLD MRI compared to H215O PET/CT for the hemodynamic evaluation of patients with Moyamoya Disease
ConclusionsThe present analysis indicates that CO2-triggered BOLD MRI is a very promising tool for the hemodynamic evaluation of MMD patients with results comparable to those seen in H215O PET/CT with ACZ challenge. It therefore holds future potential in becoming a routine examination in the pre- and postoperative evaluation of MMD patients after further prospective evaluation.
Source: NeuroImage: Clinical - February 5, 2019 Category: Radiology Source Type: research

Superficial temporal artery-middle cerebral artery anastomosis patency correlates with cerebrovascular reserve in adult moyamoya syndrome patients.
CONCLUSION: Our data suggest that improvement in cerebral perfusion and CVR depends on flow in the STA-MCA anastomosis in patients with Moyamoya syndrome. Systematic long-term follow-up of anastomosis flow, brain perfusion and CVR improves quantification of the benefit of STA-MCA anastomosis in terms of disease progression. PMID: 31185229 [PubMed - as supplied by publisher]
Source: Neuro-Chirurgie - June 7, 2019 Category: Neurosurgery Authors: Aboukais R, Verbraeken B, Leclerc X, Gautier C, Henon H, Vermandel M, Menovsky T, Lejeune JP Tags: Neurochirurgie Source Type: research

Hemodynamic evaluation of patients with Moyamoya Angiopathy: comparison of resting-state fMRI to breath-hold fMRI and 15Owater PET
ConclusionThe present analysis indicates that rs-fMRI might be a promising non-invasive method with almost no patient cooperation needed to evaluate the CVR. Further prospective studies are required.
Source: Neuroradiology - February 17, 2022 Category: Radiology Source Type: research