• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The battle against malaria in Africa has stalled. Can research in Mozambique explain why?
.news-article__hero--featured .parallax__element{ object-position: 45% 50%; -o-object-position: 45% 50%; } .news-article__figure.inset { float: right !important; width: 33%; margin: 0.5rem 0 0.5rem 1rem; } @media (min-width: 576px) { .news-article__figure.inset { width: 25%; margin: 0.5rem 0 0.5rem 2rem; } } @media (min-width: 768px) { .news-article__figure.inset { width: 40%; margin: 0.5rem 0 0.5rem 1rem; } } Moisés Mapanga, a burly man of 49, is the bait. At 6 p.m. on a mid-April evening, he climbs into an orange tent outside his one-room house in Matutuíne, a hot, swampy district near Maputo, the cap...
Source: Science of Aging Knowledge Environment - September 8, 2022 Category: Geriatrics Source Type: research

Infectious causes of acute encephalitis syndrome hospitalizations in Central India, 2018-20
CONCLUSIONS: The Japanese encephalitis virus continues to be the leading cause of acute encephalitis syndrome in central India despite vaccination among children. Surveillance needs to be strengthened along with advanced diagnostic testing for assessing the impact of vaccination.PMID:35687988 | DOI:10.1016/j.jcv.2022.105194
Source: Herpes - June 10, 2022 Category: Infectious Diseases Authors: Babasaheb V Tandale Shilpa J Tomar Vijay P Bondre Gajanan N Sapkal Rekha G Damle Rahul Narang Mohiuddin S Qazi Padmaja V Goteti Manish Jain Dipty Jain Vijay Kumar Guduru Jyoti Jain Rajesh V Gosavi V Chandra Sekhar Infectious-Encephalitis-Aetiologies Study Source Type: research

Immunomodulatory role of Th17 pathway in experimental visceral leishmaniasis
Immunobiology. 2021 Oct 25;226(6):152148. doi: 10.1016/j.imbio.2021.152148. Online ahead of print.ABSTRACTVisceral leishmaniasis (VL) or Kala-azar is a vector borne protozoan infection caused by Leishmania donovani in the Indian subcontinent mainly India, Nepal and Bangladesh. It is a major public health problem in these countries mostly affecting the socio-economically poor population. Leishmaniasis ranks the third most important disease after malaria and filariasis but is still considered as one of the neglected tropical diseases of the world. For development of better therapeutic agents and effective vaccine against VL,...
Source: Immunobiology - November 13, 2021 Category: Allergy & Immunology Authors: Rasmita Khatonier Giasuddin Ahmed Pallab Sarmah Kanwar Narain Abdul Mabood Khan Source Type: research

Plasmodium vivax vaccine candidate MSP1 displays conserved B-cell epitope despite high genetic diversity
This study analyses the impact of genetic variability on the epitope organization of different Pvmsp1 blocks. Ten blood samples collected from P. vivax infected malaria patients from West Bengal, India were used to analyze sequence and antigenic diversities of block 2 region of Pvmsp1. An additional 48 block 2 sequences from other countries were also analyzed. Global genetic framework of Pvmsp1 block 2 was represented by 12 indel clusters & 33 haplotypes (haplotype diversiy = 0.965 ± 0.024). Parasite sequences pertaining to other Pvmsp1 modules, namely block 6 and 10 displayed 14 & 29 (haplotype diversiy = 0.975 Â...
Source: Infection, Genetics and Evolution - May 22, 2021 Category: Genetics & Stem Cells Authors: Sharmistha Ghoshal Sumana Datta Kanjilal Sanghamitra Sengupta Source Type: research

Transforming the Global Economy or Parachuting Cats into Borneo?
Credit: United Nations Office for Disaster Risk Reduction (UNDRR)By Lawrence SurendraBANGKOK, Thailand, Aug 24 2020 (IPS) The COVID 19 Pandemic continues relentlessly. Deaths approaching a million globally, 22 million infected and growing. Brazil, India, the US and Russia accounting for almost 50% of the total cases in the world. Medically the promise of a vaccine is given as signs of hope; what surprises awaits us when such a vaccine is available, would be another story. Economically, to address the uncertainty and the grim future ahead, the UN, some governments and even Joe Biden the US Presidential hopeful, are waving ...
Source: IPS Inter Press Service - Health - August 24, 2020 Category: International Medicine & Public Health Authors: Lawrence Surendra Tags: Development & Aid Featured Global Headlines Health Humanitarian Emergencies IPS UN: Inside the Glasshouse Population Poverty & SDGs TerraViva United Nations Source Type: news

Nucleoside Hydrolase NH 36: A Vital Enzyme for the Leishmania Genus in the Development of T-Cell Epitope Cross-Protective Vaccines
Conclusions Nucleoside hydrolases are vital enzymes for the replication of Leishmania, conserved phylogenetic marker of the genus and strong-specific immunogens. We demonstrated that NH36 is an excellent target for chemotherapy of visceral leishmaniasis. Searching for the most immunogenic fraction of promastigotes of Leishmania we described the FML antigen of L. (L.) donovani, that has as its main component, the NH36 Nucleoside hydrolase. We developed second–generation vaccines with the FML and the NH36 native antigens, and with the NH36 recombinant protein. In addition, we obtained a third generation vaccine base...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Fight Aging! Newsletter, January 28th 2019
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - January 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs