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Plague vaccines: new developments in an ongoing search
Appl Microbiol Biotechnol. 2021 Jun 18. doi: 10.1007/s00253-021-11389-6. Online ahead of print.ABSTRACTAs the reality of pandemic threats challenges humanity, exemplified during the ongoing SARS-CoV-2 infections, the development of vaccines targeting these etiological agents of disease has become increasingly critical. Of paramount concern are novel and reemerging pathogens that could trigger such events, including the plague bacterium Yersinia pestis. Y. pestis is responsible for more human deaths than any other known pathogen and exists globally in endemic regions of the world, including the four corners region and North...
Source: Applied Microbiology and Biotechnology - June 18, 2021 Category: Microbiology Authors: Jason A Rosenzweig Emily K Hendrix Ashok K Chopra Source Type: research
Reproducibility and persistence of individual marks on 3000 fired bullets from five Chinese Norinco QSZ-92 9 × 19 mm pistols, and the search performance of Evofinder < sup > ® < /sup > to a 1000 firearm database of the same model firearm
J Forensic Sci. 2021 Jul 20. doi: 10.1111/1556-4029.14794. Online ahead of print.ABSTRACTFor firearm identification, foundational validity based on the reproducibility and persistence of characteristic marks must be established. We investigate the fired bullets of five Chinese Norinco QSZ-92 9 × 19 mm pistols over 3000 shots. The first 50 fired bullets are recovered, whereas every 50th fired bullet is recovered from the 51st to 3000th round. As such, 109 bullets are available for each pistol, and totally 545 bullets are introduced into the Evofinder® system. A large background database comprising 3000 bullets fired from ...
Source: Journal of Forensic Sciences - July 21, 2021 Category: Forensic Medicine Authors: Zhongbo Wei Yaping Luo Peng Zhou Kewei Ji Source Type: research
Molecules, Vol. 27, Pages 7336: Homology Modeling and Molecular Dynamics-Driven Search for Natural Inhibitors That Universally Target Receptor-Binding Domain of Spike Glycoprotein in SARS-CoV-2 Variants
Julia Saloni
The rapid spread of SARS-CoV-2 required immediate actions to control the transmission of the virus and minimize its impact on humanity. An extensive mutation rate of this viral genome contributes to the virus&rsquo; ability to quickly adapt to environmental changes, impacts transmissibility and antigenicity, and may facilitate immune escape. Therefore, it is of great interest for researchers working in vaccine development and drug design to consider the impact of mutations on virus-drug interactions. Here, we propose a multitarget drug discovery pipeline for identifying potential drug candidates w...
Source: Molecules - October 28, 2022 Category: Chemistry Authors: Olha Ovchynnykova Karina Kapusta Natalia Sizochenko Kostyantyn M. Sukhyy Wojciech Kolodziejczyk Glake A. Hill Julia Saloni Tags: Article Source Type: research
Supramolecular self-assembled AIE molecules are used in the search for target proteins in norcantharidin
Anal Chim Acta. 2023 Jan 25;1239:340642. doi: 10.1016/j.aca.2022.340642. Epub 2022 Nov 18.ABSTRACTNorcantharidin (NCTD), a demethylated derivative of cantharidin, is an anticancer active component in traditional Chinese medicine. At present, the main methods for finding its target proteins are pharmacological methods and biophysical screening, which cannot achieve the purpose of efficient and accurate screening. Here we established a new analytical method for specific fishing and assisted imaging for norcantharidin target proteins. For the AIE supramolecule probe, the benzophenone azide (BPA) fluorescent nanoparticles with...
Source: Analytica Chimica Acta - January 11, 2023 Category: Chemistry Authors: Lijuan Ma Xuetong Sun Wenwen Ji Bei Zhang Jianting Li Wenjuan Fu Xiangying Zhang Wenhui Qian Enze Sheng Dong Zhu Source Type: research
A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants
Conclusions:
Our estimates corroborate reports from several recent epidemiological studies of associations between PBDE exposures and neurobehavioral outcomes, and they support the inclusion of BDE-209 in the persistent organic pollutant (POP) convention as well as the need for strategies to reduce exposures to PBDE mixtures, including maximum residue limits for PBDEs in food and measures for limiting the release of PBDEs from consumer waste. https://doi.org/10.1289/EHP826
Received: 18 July 2016
Revised: 06 May 2017
Accepted: 09 May 2017
Published: 23 August 2017
Address correspondence to A. Kortenkamp, Brunel Univer...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Estimated Effects of Future Atmospheric CO2 Concentrations on Protein Intake and the Risk of Protein Deficiency by Country and Region
Conclusions:
Anthropogenic CO2 emissions threaten the adequacy of protein intake worldwide. Elevated atmospheric CO2 may widen the disparity in protein intake within countries, with plant-based diets being the most vulnerable. https://doi.org/10.1289/EHP41
Received: 27 February 2016
Revised: 12 September 2016
Accepted: 19 September 2016
Published: 02 August 2017
Address correspondence to D. Medek, North Shore Hospital, Shakespeare Ave., Takapuna, Auckland, New Zealand 0622. Telephone: 649 486 8900. Email: danielle.medek@gmail.com
Supplemental Material is available online (https://doi.org/10.1289/EHP41).
The authors d...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence
Conclusions:
Population level of iAs% and DMA%, but not MMA%, were associated with arsenic exposure levels. Overall, study findings suggest that higher MMA% was associated with an increased risk of cancer and cardiovascular disease, while lower MMA% was associated with an increased risk of diabetes and metabolic syndrome. Additional population-based studies and experimental studies are needed to further evaluate and understand the role of arsenic exposure in arsenic metabolism and the role of arsenic metabolism in disease development. https://doi.org/10.1289/EHP577
Received: 01 June 2016
Revised: 26 February 2017
Acce...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Relationship Between Maternal Negative Emotions and Feeding Patterns of Infants Aged 0-6 Months in Remote Rural Areas of Sichuan Province
Conclusions The mothers in the remote rural areas of Sichuan province are more likely to employ bottle feeding than exclusive breastfeeding.The mothers with stronger depression tendency demonstrate lower possibility of exclusive breastfeeding and higher possibility of bottle feeding.Breastfeeding self-efficacy may affect the association between maternal depression and infant feeding patterns.PMID:37654134 | DOI:10.3881/j.issn.1000-503X.15375
Source: Rural Remote Health - September 1, 2023 Category: Rural Health Authors: Chen-Fan Liao Zheng-Jie Cai Fang-Qun Leng Rui-Qian Wang Ying Liao Yu-Ju Wu Huan Zhou Source Type: research
Understanding mammographic breast density profile in China: A Sino-Australian comparative study of breast density using real-world data from cancer screening programs
CONCLUSIONS: Both PD and DA were found to be higher in Chinese women compared to Australian women. The density difference by menopause status was shown and breastfeeding history affected breast density differently in both populations.PMID:35238173 | DOI:10.1111/ajco.13763
Source: Clinical Breast Cancer - March 3, 2022 Category: Cancer & Oncology Authors: Tong Li Jing Li Rob Heard Ziba Gandomkar Jiansong Ren Min Dai Patrick Brennan Source Type: research
