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Nutrition: Vitamin B9
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Total 60 results found since Jan 2013.

Effect of Smoking and Folate Levels on the Efficacy of Folic Acid Therapy in Prevention of Stroke in Hypertensive Men Clinical Sciences
Conclusions—Baseline folate levels and smoking status can interactively affect the risk of first stroke. Our data suggest that compared with never smokers, ever smokers may require a higher dosage of folic acid to achieve a greater beneficial effect on stroke. Our findings need to be confirmed by future randomized trials.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT00794885.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Ziyi Zhou, Jianping Li, Yaren Yu, Youbao Li, Yan Zhang, Lishun Liu, Yun Song, Min Zhao, Yu Wang, Genfu Tang, Mingli He, Xiping Xu, Yefeng Cai, Qiang Dong, Delu Yin, Xiao Huang, Xiaoshu Cheng, Binyan Wang, Fan Fan Hou, Xiaobin Wang, Xianhui Qin, Yong Huo Tags: Primary Prevention, Hypertension, Treatment, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Association between percent decline in serum total homocysteine and risk of first stroke
Conclusions: Percent lowering in tHcy was significantly associated with a reduction in first stroke risk in Chinese adults with hypertension, and if further confirmed, may serve as a useful indicator for folic acid treatment efficacy on stroke prevention. Clinicaltrials.gov identifier: NCT00794885.
Source: Neurology - November 13, 2017 Category: Neurology Authors: Huang, X., Li, Y., Li, P., Li, J., Bao, H., Zhang, Y., Wang, B., Sun, N., Wang, J., He, M., Yin, D., Tang, G., Chen, Y., Cui, Y., Huang, Y., Hou, F. F., Qin, X., Huo, Y., Cheng, X. Tags: Stroke prevention, All Clinical trials ARTICLE Source Type: research

Plasma retinol and the risk of first stroke in hypertensive adults: a nested case-control study.
Conclusions: Our data showed a significant inverse association between plasma retinol and the risk of first stroke among Chinese hypertensive adults. This study was registered at clinicaltrials.gov as NCT00794885. PMID: 30624586 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 9, 2019 Category: Nutrition Authors: Yu Y, Zhang H, Song Y, Lin T, Zhou Z, Guo H, Liu L, Wang B, Liu C, Li J, Zhang Y, Huo Y, Wang C, Wang X, Hou FF, Qin X, Xu X Tags: Am J Clin Nutr Source Type: research

Plasma selenium and the risk of first stroke in adults with hypertension: a secondary analysis of the China Stroke Primary Prevention Trial
CONCLUSIONS: In summary, there was a significant inverse association between plasma Se and risk of first stroke in Chinese adults with hypertension, especially among those with higher baseline folate concentrations and those with higher time-averaged SBP over the treatment period.Trial registration number: NCT00794885URL of registration: https://www.clinicaltrials.gov/ct2/show/NCT00794885?term=NCT00794885&draw=2&r.PMID:34549258 | DOI:10.1093/ajcn/nqab320
Source: The American Journal of Clinical Nutrition - September 22, 2021 Category: Nutrition Authors: Zhuo Wang Hai Ma Yun Song Tengfei Lin Lishun Liu Ziyi Zhou Yaping Wei Xiao Huang Ping Chen Chengzhang Liu Youbao Li Binyan Wang Jianping Li Yan Zhang Yong Huo Hao Zhang Xiping Xu Xianhui Qin Huiyuan Guo Source Type: research

Self-Perceived Psychological Stress and Risk of First Stroke in Treated Hypertensive Patients
Objective We aimed to investigate the prospective association between self-perceived psychological stress and first stroke, and to examine possible effect modifiers among adults with hypertension. Methods A total of 20,688 hypertensive adults with information on self-perceived psychological stress at baseline were included from the China Stroke Primary Prevention Trial. Participants were randomly assigned to a double-blind treatment of receiving a single tablet daily with either 10 mg enalapril and 0.8 mg folic acid or 10 mg enalapril alone. Follow-up visits occurred every 3 months after randomization. Psycholog...
Source: Psychosomatic Medicine - February 1, 2022 Category: Psychiatry & Psychology Tags: ORIGINAL ARTICLES Source Type: research

Effect of Intensive Blood Pressure Control on Carotid Morphology and Hemodynamics in Chinese Patients with Hyperhomocysteinemia-Type Hypertension and High Risk of Stroke.
CONCLUSIONS Intensive blood pressure management could be beneficial for Chinese patients with hyperhomocysteinemia-type hypertension and high risk of stroke. PMID: 31369520 [PubMed - in process]
Source: Medical Science Monitor - August 3, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Network Pharmacology-Based Identification Study on the Mechanism of Xiao-Xu-Ming Decoction for Cerebral Ischemic Stroke.
Conclusion: This study initially clarified the main targets and pathways of XXMD in the treatment of CIS, which can lay the foundation for further research on its pharmacological effects. PMID: 33133212 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - November 3, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cost-effectiveness of folic acid therapy for primary prevention of stroke in patients with hypertension
For hypertensive patients without a history of stroke or myocardial infarction (MI), the China Stroke Primary Prevention Trial (CSPPT) demonstrated that treatment with enalapril-folic acid reduced the risk of ...
Source: BMC Medicine - October 25, 2022 Category: Internal Medicine Authors: Tiantian Zhang, Zhuoru Liang, Tengfei Lin, David J. Cohen, Alejandro Arrieta, Xiaobin Wang, Xianhui Qin, Binyan Wang, Yong Huo, Gordon G. Liu, Jie Jiang and Zugui Zhang Tags: Research article Source Type: research

Xiaoxuming Decoction Regulates Vascular Function by Modulating G Protein-Coupled Receptors: A Molecular Docking Study
In this study, XXMD was found to induce relaxation of the basilar artery rings of rats precontracted by 5-hydroxytryptamine (5-HT) in vitro, in a dose-dependent manner. The modulation of vascular tone and the process of cerebral ischemia are mediated via the interactions between G protein-coupled receptors (GPCRs) and their ligands, including 5-HT, angiotensin II (Ang II), and urotensin II (UII). Thus, the potential synergistic effects of the different components of XXMD on the regulation of vasoconstriction and vasodilation were further investigated by molecular docking based on network pharmacology. We constructed and an...
Source: Biomed Res - July 1, 2021 Category: Research Authors: Yanjia Shen Ran Yang Rui Zhou Wendan Lu Li Li Ziran Niu Miao Chen Jinhua Wang Yuehua Wang Lianhua Fang Guanhua Du Source Type: research

Effects of Folic Acid Therapy on the New-Onset Proteinuria in Chinese Hypertensive PatientsNovelty and Significance Clinical Trials
In conclusion, enalapril–folic acid therapy, compared with enalapril alone, significantly reduced the development of proteinuria in diabetic patients with hypertension.Clinical Trial Registration—URL: http://www.ClinicalTrials.gov. Unique identifier: NCT00794885.
Source: Hypertension - July 12, 2017 Category: Cardiology Authors: Youbao Li, Min Liang, Guobao Wang, Binyan Wang, Mingli He, Genfu Tang, Delu Yin, Xin Xu, Yong Huo, Yimin Cui, Fan Fan Hou, Xianhui Qin Tags: Clinical Studies, Diabetes, Type 1, Diet and Nutrition, Hypertension Original Articles Source Type: research

Supplements Won't Prevent Heart Disease: Study
There was one exception, researchers said. A more recent clinical trial in China found that folic acid supplements helped curb participants' risk of stroke.
Source: WebMD Health - May 29, 2018 Category: Consumer Health News Source Type: news