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Anti-tumor activity of trimethoprim-sulfamethoxazole against melanoma skin cancer through triggering allergic reaction and promoting immunity
This study examined the potential roles of TMP-SMX in melanoma skin cancer using an immunodeficient mouse model. TMP-SMX significantly improved the survival rate and reduced the tumor weight and growth and vascular endothelial growth factor levels in melanoma skin cancer of immunodeficient mice. In the forced swimming test, TMP-SMX significantly reduced immobility time compared to the melanoma skin cancer of immunodeficient mice, indicating improved immunity. TMP-SMX significantly increased infiltration of mast cells and release of allergy-related mediators (IgE, histamine, interleukin (IL)-4, IL-5, IL-13, and IL-33) and i...
Source: International Immunopharmacology - August 3, 2023 Category: Allergy & Immunology Authors: Hee-Yun Kim Ho-Geun Kang Hyung-Min Kim Hyun-Ja Jeong Source Type: research

Drug allergy biomarkers
Although the true burden of drug allergy is unknown, several studies indicate that adverse drug reactions occur in up to 6% to 10% of hospitalized patients —20% of which are because of drug allergy—and up to 10% of the general population claims to have penicillin or other drug allergies.1 A plethora of new antibiotics, vaccines, chemotherapy drugs, and, more recently, biologicals and targeted molecular drugs are available and have improved disease treatment options, but drug allergy remains a vexing and unaddressed problem that deprives patients of the best medication for their disease, and when re-exposed, places them...
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Mariana Castells Tags: Editorial Source Type: research

Drug allergy desensitization is not a unique recipe
Purpose of review Drug desensitization is the only therapeutic option for patients with drug allergies who need to receive the drugs they are allergic to, and it is especially critical in patients with an urgent need for chemotherapy, biologics, or antibiotics, where equally effective alternatives might not be available. However, drug desensitization is not a cookbook where anyone with no experience or specific training can find a general recipe. This review article will approach the singularities that make personalized and highly specialized care essential in this field. Recent findings Drug desensitization nee...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research

Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
AbstractThis guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Society for Chemotherapy in a  consensus procedure according to the criteria of the German Association of Scientific Medical Societies. BLA such as penicillins and cephalosporins represent the drug group that most frequently triggers drug allergies. However, the frequency of reports of suspected allergy in patient histories cle arly exceeds the number of confirmed cases. The large number of suspected BLA allergies ...
Source: Allergo Journal International - July 21, 2019 Category: Allergy & Immunology Source Type: research

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Evaluation of Morbidity and Mortality from Drug Allergies in Patient with Acute Myeloid Leukemia
Patients with a drug allergy are known to have increased morbidity and mortality. Patients with Acute Myeloid Leukemia (AML) are known to have recurrent severe infections due to immunosuppression from chemotherapy. The prevalence of drug allergy in patients with AML and its effect on morbidity and mortality has not been previously studied.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Maria Paula Henao, Faoud Terrence Ishmael Source Type: research

Options in Hypersensitivity Reactions to Chemotherapeutics
This article has tried to highlight and summarize the most recent scientific progress concerning risk factors, pathogenesis, diagnosis, and treatment of these reactions.Recent findingsIdentification of patients at high risk of developing hypersensitivity reactions allows risk stratification to guide clinical decision-making. Therefore, the most recent researches evaluated the possibility to perform risk stratification in case of hypersensitivity reactions to platinum compounds and taxanes. In addition, new data are now available regarding the role of in vitro test for the diagnosis of reactions to platins and the role of d...
Source: Current Treatment Options in Allergy - January 30, 2018 Category: Allergy & Immunology Source Type: research

Desensitization for hypersensitivity reactions to medications.
Authors: del Carmen Sancho M, Breslow R, Sloane D, Castells M Abstract Rapid drug desensitization (RDD) is a technique that induces temporary tolerance to a drug, allowing a medication-allergic patient to receive the optimal agent for his or her disease. Through RDD, patients with IgE and non-IgE hypersensitivity reactions (HSRs) including anaphylaxis can safely be administered important medications while minimizing or completely inhibiting adverse reactions. Adverse reactions to drugs are increasingly recognized as important contributors to disease as well as impediments to the best treatment of dermatological, in...
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Combined DOCK8 and CLEC7A mutations causing immunodeficiency in 3 brothers with diarrhea, eczema, and infections
We report 4 brothers from a consanguineous Italian family with an immunodeficiency syndrome characterized by severe eczema, milk and egg allergies, recurrent infections, intractable diarrhea, failure to thrive, and, in 2 of the 3 surviving brothers, lymphoma. One of the brothers (patient II-2) died at age 12 months of cardiovascular failure caused by intractable diarrhea, and the other 3 were evaluated as part of this study ( and , A). The proband (patient II-1) presented shortly after birth with severe eczema and intractable diarrhea without gastrointestinal infection. In the first year of life, he had multiple allergies ...
Source: Journal of Allergy and Clinical Immunology - February 1, 2013 Category: Allergy & Immunology Authors: Darrell L. Dinwiddie, Stephen F. Kingsmore, Sonia Caracciolo, Giuseppe Rossi, Daniele Moratto, Cinzia Mazza, Cristiano Sabelli, Rosa Bacchetta, Laura Passerini, Chiara Magri, Callum J. Bell, Neil A. Miller, Shannon L. Hateley, Carol J. Saunders, Lu Zhang, Tags: Letters to the Editor Source Type: research