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Total 208 results found since Jan 2013.

Quercetin protects against Aspergillus fumigatus keratitis by reducing fungal load and inhibiting TLR-4 induced inflammatory response
CONCLUSION: Quercetin plays a protective role in mouse A. fumigatus keratitis by inhibiting fungal load, disrupting hyphae structure, macrophage infiltration, and suppressing inflammation response in macrophages via TLR-4 mediated signaling pathway.PMID:37677994 | DOI:10.1016/j.cyto.2023.156356
Source: Cytokine - September 7, 2023 Category: Molecular Biology Authors: Junjie Luan Yunan Zhu Jing Lin Yingxue Zhang Qiang Xu Lu Zhan Xue Tian Guiqiu Zhao Xudong Peng Source Type: research

Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine ‐Based Carriers for Sirna Delivery by Systemic and Intratumoral Administration.
Positron emission tomography is used to study the fate of polyplexes formed by siRNA and modified polyamines. Polyplexes are prepared with either radiolabeled siRNA or radiolabeled polyamines. By comparing biodistribution patterns of labeled siRNA and labeled polyamines conclusions are driven on the stability of the polyplexes in vivo. AbstractPolyamine-based vectors offer many advantages for gene therapy, but they are hampered by a limited knowledge on their biological fate and efficacy for nucleic acid delivery. The18F radiolabeled siRNA is complexed with poly(allyl amine) hydrochloride (PAH), PEGylated PAH (PAHPEG), or ...
Source: Small - August 4, 2023 Category: Nanotechnology Authors: Cristina Simo, Cristian Salvador, Patrizia Andreozzi, Vanessa Gomez ‐Vallejo, Gabriela Romero, Damien Dupin, Jordi Llop, Sergio E. Moya Tags: Research Article Source Type: research

Evaluation of an Integrin α v β 3 Radiotracer, 18 FF-FPP-RGD 2 , for Monitoring Pharmacological Effects of Integrin α v siRNA in the NASH Liver
CONCLUSION: This study suggests that [18F]F-FPP-RGD2 PET imaging is a promising radiotracer for monitoring hepatic integrin αv protein levels and hepatic function in NASH pathology.PMID:37483876 | PMC:PMC10359219 | DOI:10.1007/s13139-023-00791-9
Source: Molecular Medicine - July 24, 2023 Category: Molecular Biology Authors: Shuichi Hiroyama Keiko Matsunaga Miwa Ito Hitoshi Iimori Ippei Morita Jun Nakamura Eku Shimosegawa Kohji Abe Source Type: research

Cdc42 Regulates the Expression of Cytoskeleton and Microtubule Network Proteins to Promote Invasion and Metastasis of Progeny Cells Derived from CoCl 2 -induced Polyploid Giant Cancer Cells
Conclusion: CoCl2-induced overexpression of Cdc42 plays a critical role in increasing the infiltration and migration abilities of PGCCs and progeny cells by regulating cytoskeleton protein expression.PMID:37476197 | PMC:PMC10355212 | DOI:10.7150/jca.85032
Source: Cancer Control - July 21, 2023 Category: Cancer & Oncology Authors: Minying Zheng Lankai Chen Junjie Fu Xiaohui Yang Shuo Chen Wenzheng Fu Yuwei Li Shiwu Zhang Source Type: research

The Role of Decorin in the Adhesion Process of Treponema Pallidum Subspecies Pallidum to Human Brain Microvascular Endothelial Cells
CONCLUSIONS: Decorin enhances the adhesion of T. pallidum to human brain microvascular endothelial cells, suggesting that decorin may act as one of the receptors regulating the adhesion of T. pallidum to cells. Furthermore, T. pallidum treatment triggers the rearrangement of F-actin in cells, and decorin plays a protective role in this process.PMID:37471666
Source: Alternative Therapies in Health and Medicine - July 20, 2023 Category: Complementary Medicine Authors: Fan Wu Xiaoli Dai Tingyu Xue Fangzhi Du Qianqiu Wang Bin Chen Source Type: research

Eco-friendly deacetylated chitosan base siRNA biological-nanopesticide loading cyromazine for efficiently controlling Spodoptera frugiperda
Int J Biol Macromol. 2023 Apr 24:124575. doi: 10.1016/j.ijbiomac.2023.124575. Online ahead of print.ABSTRACTSpodoptera frugiperda is a serious threat to various crops, such as corn and rice, and results in severe economic losses. Herein, a chitin synthase sfCHS highly expressed in the epidermis of S. frugiperda was screened, and when interfered by an sfCHS-siRNA nanocomplex, most individuals could not ecdysis (mortality rate 53.3 %) or pupate (abnormal pupation 80.6 %). Based on the results of structure-based virtual screening, cyromazine (CYR, binding free energy -57.285 kcal/mol) could inhibit ecdysis (LC50, 19.599 μg/g...
Source: International Journal of Biological Macromolecules - April 26, 2023 Category: Biochemistry Authors: Changwei Gong Ali Hasnain Qiulin Wang Dan Liu Zhengze Xu Xiaoxu Zhan Xuemei Liu Jian Pu Mengmeng Sun Xuegui Wang Source Type: research

Evaluation of an Integrin αvβ3 Radiotracer, 18FF-FPP-RGD2, for Monitoring Pharmacological Effects of Integrin αv siRNA in the NASH Liver
ConclusionThis study suggests that [18F]F-FPP-RGD2 PET imaging is a promising radiotracer for monitoring hepatic integrin αv protein levels and hepatic function in NASH pathology.
Source: Nuclear Medicine and Molecular Imaging - March 7, 2023 Category: Nuclear Medicine Source Type: research

Glabridin Inhibits Aspergillus fumigatus Growth and Alleviate Inflammation Mediated by Dectin-2 and NLRP3 Inflammasome
CONCLUSION: Glabridin plays an anti-inflammatory role in A. fumigatus challenge via suppression of the Dectin-2 and NLRP3 inflammasome, and plays an anti-fungal role through delaying germination and changing the hyphal integrity.KEY MESSAGESGlabridin plays an anti-inflammatory role in A. fumigatus infection of RAW264.7 cells in a concentration-dependent manner and through Dectin-2 mediation.Glabridin decreases fungal distribution and inflammation in mouse A. fumigatus keratitis.Glabridin inhibits A. fumigatus growth by delaying germination and disrupting cellular structure in vitro.PMID:36785524 | DOI:10.1080/02713683.2022.2164779
Source: Current Eye Research - February 14, 2023 Category: Opthalmology Authors: Lu Zhan Xue Tian Jing Lin Xudong Peng Guiqiu Zhao Source Type: research

Eukaryotic initiation factor 5A hypusine as a negative regulator of adenosine 2B receptor (A2bAR) through interaction with stem loop sequences within the A2bAR 3'-untranslated region
CONCLUSIONS: eIF5AHyp acts as a negative regulator of A2bAR gene expression through stem loop sequences in A2bAR 3'UTR, allowing differentiation of adipocytes.PMID:36689050 | DOI:10.1007/s11033-023-08252-4
Source: Molecular Biology Reports - January 23, 2023 Category: Molecular Biology Authors: Grace Kelly Lee Chang Wook Kim Ik-Hyun Cho Hae-Yeong Kim Jong Hwan Park Source Type: research

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