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Vaccination: Malaria Vaccine
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Total 1933 results found since Jan 2013.
A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes, Sporozoites, and Liver-Stages
This reporter line has been used to analyze liver infection in immune-deficient humanized mice engrafted with human liver tissue ((Sack et al., 2014; Flannery et al., 2018); (Foquet et al., 2018)).
In multiple RMP transgenic lines the uis4 gene promoter has been used to drive expression of different transgenes in sporozoites and liver-stages, such as genes encoding mCherry, ovalbumin or human Plasmodium proteins (Combe et al., 2009; Panchal et al., 2012; Montagna et al., 2014; Hopp et al., 2015; Longley et al., 2015, 2017; Singer et al., 2015) The uis4 gene, a member of the small Plasmodium etramp gene family, is highly t...
Source: Frontiers in cellular and infection microbiology - April 15, 2019 Category: Microbiology Source Type: research
An Animal Model of Acute and Chronic Chagas Disease With the Reticulotropic Y Strain of Trypanosoma cruzi That Depicts the Multifunctionality and Dysfunctionality of T Cells
In conclusion, during acute T. cruzi infection with the reticulotropic Y strain, immune activation leads to the generation of antigen-specific multifunctional CD4+ Th1 and CD8+ Tc1 cells and their regulation by inhibitory receptor co-expression. In contrast, during chronic T. cruzi infection, the chronicity of the infection induces a moderate inflammatory infiltrate in colon and liver tissues accompanied with poor T cell effector function that is possibly related to the co-expression of inhibitory receptors on T cells, but this phenomenon does not occur in cytotoxic CD8+ T cells. Taken together, these data supp...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research
Travelling with children and adolescents with rheumatic diseases
Z Rheumatol. 2021 Apr 27. doi: 10.1007/s00393-021-01002-6. Online ahead of print.ABSTRACTDue to the underlying disease and immunosuppressive treatment, pediatric patients with rheumatic diseases are at increased risk for (long distance) travel-related health problems. A pretravel comprehensive consultation is therefore strongly recommended. Whether a child with rheumatic disease is sufficiently fit for travel essentially depends on the disease activity, the age of the child and the intended travel destination. Depending on the level of immunosuppression, the risks for this patient group include (travel-related) infections ...
Source: Zeitschrift fur Rheumatologie - April 27, 2021 Category: Rheumatology Authors: M Freudenhammer M Hufnagel Source Type: research
First Came an Earthquake. Then a Hurricane. Now, Haiti is Bracing for an Outbreak of Disease.
On Aug. 14, a devastating 7.2-magnitude earthquake hit southwestern Haiti, leaving 2,189 people dead, 12,268 injured and at least 332 missing. Days later, Tropical Storm Grace swept over the ravaged landscape, hampering the complicated search and rescue mission. Yet aid groups say this is only the beginning of the crisis.
The island country of nearly 12 million people has faced one disaster after another in the space of a few weeks. In July, President Jovenel Moïse was assassinated amid mounting allegations of corruption. The country has been struggling with poverty, disease and a fractured infrastructure since a cata...
Source: TIME: Health - August 20, 2021 Category: Consumer Health News Authors: Eloise Barry Tags: Uncategorized Londontime Natural Disasters Source Type: news
First Came an Earthquake. Then a Hurricane. Now, Haiti is Bracing for an Outbreak of Disease
On Aug. 14, a devastating 7.2-magnitude earthquake hit southwestern Haiti, leaving 2,189 people dead, 12,268 injured and at least 332 missing. Days later, Tropical Storm Grace swept over the ravaged landscape, hampering the complicated search and rescue mission. Yet aid groups say this is only the beginning of the crisis.
The island country of nearly 12 million people has faced one disaster after another in the space of a few weeks. In July, President Jovenel Moïse was assassinated amid mounting allegations of corruption. The country has been struggling with poverty, disease and a fractured infrastructure since a cata...
Source: TIME: Health - August 20, 2021 Category: Consumer Health News Authors: Eloise Barry Tags: Uncategorized Londontime Natural Disasters Source Type: news
Vaccines for International Pediatric Travelers
The pretravel management of the international pediatric traveler is based on provision of preventive education, chemoprophylaxis against malaria and traveler ’s diarrhea, as well as travel vaccinations. Immunization requirements are determined based on the traveler’s pretravel immunization status, age, medical history, and destination. Immunization needs also vary depending on the exposures during the trip. Potential exposure to water, insects, or an imals as well as duration of travel will help tailor risk avoidance education and travel immunizations. This review provides clinicians an overview of vaccines recommended...
Source: Pediatric Clinics of North America - November 16, 2021 Category: Pediatrics Authors: Vini Vijayan Source Type: research
News at a glance: U.S. rules on carbon emissions, better vehicle batteries, and a Mars moon ’s close-up
PLANETARY SCIENCE
Mars’s moon may be its kin
Researchers have long believed that Mars’s two moons, Deimos and Phobos, are captured asteroids. But the first close-up images of Deimos, taken by the United Arab Emirates’s $200 million Hope spacecraft, suggest the 12-kilometer-wide body instead formed from the same material as Mars, researchers revealed this week at the annual meeting of the European Geosciences Union. The imagery, taken during a 10 March flyby, indicates that Deimos’s surface is covered by volcanic basalts like those on Mars, with no signs of the carbon-rich rock more often found on ast...
Source: ScienceNOW - April 27, 2023 Category: Science Source Type: news
Prospects of using community directed intervention strategy in delivering health services among Fulani Nomads in Enugu State, Nigeria
Conclusion:
Given the definable organizational structure of the nomads in Enugu State and their desire for modern health intervention, it is feasible to test the CDI strategy for equitable healthcare delivery among nomads. They are willing and capable to participate actively in their own health programmes with minimal support from professional health workers.
Source: International Journal for Equity in Health - April 8, 2013 Category: Global & Universal Authors: Joseph OkeibunorNkechi OnyenehoObioma NwaorguNgozi I¿AronuIjeoma OkoyeFelicia IremekaJohannes Sommerfeld Source Type: research
Kenya: Kenyan Awarded for Malaria Vaccine Study
[The Star]A Kenyan scientist has been awarded for her pioneering research that boosts the search for malaria vaccine. Dr Faith Osier, a research programme scientist at the Kenya Medical Research Institute (Kemri) -Wellcome Trust, received the 2014 Royal Society Pfizer Prize.
Source: AllAfrica News: Malaria - August 11, 2014 Category: Infectious Diseases Source Type: news
A behind the scenes peek at BioMed Central publishing roles
What is your science background?
Ben: My main research interest has always been viruses, which started during my undergraduate degree in virology at the University of Warwick. I then spent four years researching influenza virus for my doctoral research at the University of Reading. After this I moved on to a postdoc position at Imperial College London to test safer smallpox vaccines.
Ripu: I have a PhD in human genetics specializing in human diversity and evolution in sub-Saharan African. I also have a Master’s degree in Medical Parasitology and a Diploma in infectious diseases, and while studying for these two degrees, ...
Source: BioMed Central Blog - February 11, 2016 Category: Journals (General) Authors: Dana Berry Tags: Biology Health Medicine #moretoscience careers early career researchers PhD Science>Careers Source Type: blogs
Finding the Origin of Human Disease
We're still trying to eradicate diseases that have plagued humans for centuries. References to malaria, for instance, have been found in recorded history in 2700 BC China. Riaan Rifkin, a prehistoric archaeologist, together with geneticists at the University of Pretoria, South Africa gets down to the root of origins of human disease pathogens in sub-Saharan Africa, the cradle of mankind. He and his team are trying to pin down the origins of human disease and establish a sub-Saharan African disease baseline that precedes the exodus of Homo sapiens from Africa 65000 years ago and, perhaps, to also assist in the discovery of ...
Source: Science - The Huffington Post - May 18, 2016 Category: Science Source Type: news
Bill Gates Talks to TIME About a Coming ‘Third Wave’ of Development in Africa
There’s a very big difference between simple and easy—especially when it comes to global health. It’s simple to eradicate polio—just get all children are vaccinated. It’s simple to reduce nighttime malaria infections—make sure everyone in malaria-endemic areas sleeps under a bed net. But none of that is easy.
The tension between simple and easy is at play when it comes to eradicating poverty in the developing world too, as the Bill & Melinda Gates Foundation makes clear in its second annual Goalkeepers Data Report.
In a conversation with TIME, Bill Gates points to two recent waves of...
Source: TIME: Health - September 21, 2018 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized onetime public health Source Type: news
Should We Experimentally Infect People With Covid-19 To Speed Up Vaccine Development?
Dr. Stephen Thomas, Chief of Infectious Diseases at SUNY Upstate Medical University, discusses his experience volunteering for a malaria vaccine trial in 2001 and how to evaluate the risks of human challenge experiments in search of a coronavirus vaccine.
Source: Forbes.com Healthcare News - July 8, 2020 Category: Pharmaceuticals Authors: Stephen Thomas, Contributor Tags: Healthcare /healthcare Innovation /innovation Science /science Editors' Pick editors-pick Decision Maker decision-maker Coronavirus Source Type: news
The Great Vaccine Race: Inside the Unprecedented Scramble to Immunize the World Against COVID-19
The cleverest of enemies thrive on surprise attacks. Viruses—and coronaviruses in particular—know this well. Remaining hidden in animal hosts for decades, they mutate steadily, sometimes serendipitously morphing into more effective and efficient infectious agents. When a strain with just the right combination of genetic codes that spell trouble for people makes the leap from animal to human, the ambush begins.
Such was the case with SARS-CoV-2, the coronavirus behind COVID-19, and the attack was mostly silent and insidious at first. Many people infected with SARS-CoV-2 remained oblivious as they served as the v...
Source: TIME: Health - September 10, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Magazine Source Type: news
Implementation strategies for health systems in low-income countries: an overview of systematic reviews.
CONCLUSIONS: Reliable systematic reviews have evaluated a wide range of strategies for implementing evidence-based interventions in low-income countries. Most of the available evidence is focused on strategies targeted at healthcare workers and healthcare recipients and relates to process-based outcomes. Evidence of the effects of strategies targeting healthcare organisations is scarce.
PMID: 28895659 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - September 12, 2017 Category: General Medicine Authors: Pantoja T, Opiyo N, Lewin S, Paulsen E, Ciapponi A, Wiysonge CS, Herrera CA, Rada G, Peñaloza B, Dudley L, Gagnon MP, Garcia Marti S, Oxman AD Tags: Cochrane Database Syst Rev Source Type: research
