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Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence
Conclusions: IgG recognition of linear antigenic Env regions differed between the two trials particularly after the second MVA boost. Structural features of the MVA-encoded immunogens, such as secreted, monomeric gp120 vs. membrane-anchored, functional gp150, and differences in prime-boost immunogen sequence variability most probably contributed to these differences. Prime-boosting with multivalent Env immunogens during TMV01 did not improve variant cross-recognition of immunodominant peptide variants in the V3 region.
Introduction
Development of an efficacious vaccine against the Human Immunodeficiency Virus-1 (HI...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research
The Ambulance Science Podcast: Make Up Your Own Mind About the Vaccine
Get every episode of The Ambulance Science Podcast by subscribing to Apple Podcasts or Google Podcasts.
Where I’m coming from (compared to most of my colleagues):
Master’s in Public Health with a concentration in Health Policy from Yale Medical School.FT Faculty at GWU School of Medicine & Southern Connecticut State University MPH Program, and long-time adjunct faculty at NYMC MPH program in Health Policy.Assistant Commissioner of Health at the NYC Department of Health & Mental Hygiene during the first SARS outbreak.Served as State EMS Director, Consultant to Public Health ...
Source: JEMS Special Topics - December 14, 2020 Category: Emergency Medicine Authors: JEMS Staff Tags: Podcasts Ambulance Science Source Type: news
Close Inequalities to End AIDS & Prepare for Future Pandemics
Thembeni Mkingofa, a woman living with HIV, visits the PMTCT section of the Makhume District Hospital, Zimbabwe. She has three children - 14, 10 and 2 who are all HIV negative. This is her fourth pregnancy. Her husband is also on HIV treatment. Here she is pictured with her two-year-old daughter, Hilda Chakiryizira. 5 November 2019. Credit: UNAIDS/C. MatonhodzeBy Winnie Byanyima and Sir Michael MarmotBRASILIA, Brazil, Jun 5 2023 (IPS) The COVID-19 crisis has shone a light on the danger of pandemics; social crises have shone a light on the danger of inequalities. And the reality is that outbreaks become the pandemics they d...
Source: IPS Inter Press Service - Health - June 5, 2023 Category: International Medicine & Public Health Authors: Winnie Byanyima and Sir Michael Marmot Tags: Africa COVID-19 Development & Aid Editors' Choice Featured Headlines Health Inequity Latin America & the Caribbean Poverty & SDGs TerraViva United Nations IPS UN Bureau Source Type: news
15 thoughts on eliminating neglected tropical diseases
We summarise the points made by a live chat panel on how the global health community can work towards eliminating NTDsDr Paul Emerson, trachoma control programme director, The Carter Centre, Atlanta, USANTDs aren't as remote or obscure as many think: Trachoma and worms used to be endemic to the US and Europe, but were eliminated through improvements in hygiene, sanitation and access to medical care. NTDs still affect billions of people in the world, so the global NTD conversation needs to focus on how and why NTDs are keeping the bottom billion at the bottom.Build local support by involving community leaders: Involving tru...
Source: Guardian Unlimited Science - May 20, 2013 Category: Science Authors: Anna Scott Tags: Global health Guardian Professional Infectious diseases Pharmaceuticals industry Malaria and infectious diseases Vaccines and immunisation Health policy Editorial Global development professionals network Source Type: news
Linda MacIntyre
Chief NurseLinda MacIntyre, PhD, RN is Chief Nurse for the American Red Cross, providing leadership for nurses across five Red Cross lines of business –Biomedical Services, Disaster Services, International Services, Preparedness, Health and Safety Services and Service to the Armed Forces. Dr. MacIntyre works with the National Nursing Committee and senior leaders to provide vision, direction and support related to nursing and health in meeting the mission of the Red Cross. She serves on the Institute of Medicine Forum on Medical and Public Health Preparedness for Catastrophic Events, is a member of the Federal Nursing Ser...
Source: PHRMA - September 25, 2015 Category: Pharmaceuticals Authors: Ali Source Type: news
4 New Scientific Breakthroughs To Celebrate This World AIDS Day
There is still no cure or vaccine for HIV/AIDS, which affects approximately 37 million people around the world. But there is reason to hope that the global response to this pandemic is improving.
Fewer people died of HIV in 2015 than at any point in almost 20 years, while new HIV infections are at the lowest point since 1991, the World Health Organization noted in its 2016 progress report. That may be, in part, because at least two million new people began taking antiretroviral therapy in 2015, the largest annual increase ever in the history of the disease.
For World AIDS Day, we asked resea...
Source: Science - The Huffington Post - December 1, 2016 Category: Science Source Type: news
2016 Was A Banner Year For HIV/AIDS Research
There is still no cure or vaccine for HIV/AIDS, which affects approximately 37 million people around the world. But there is reason to hope that the global response to this pandemic is improving.
Fewer people died of HIV in 2015 than at any point in almost 20 years, while new HIV infections are at the lowest point since 1991, the World Health Organization noted in its 2016 progress report. That may be, in part, because at least two million new people began taking antiretroviral therapy in 2015, the largest annual increase ever in the history of the disease.
For World AIDS Day, we asked resea...
Source: Science - The Huffington Post - December 1, 2016 Category: Science Source Type: news
NIAID Is Dedicated To Saving The Lives Of People With TB
Originally published on niaid.nih.gov
Statement of Christine F. Sizemore, PhD., Richard Hafner, M.D., and Anthony S. Fauci, M.D. National Institute of Allergy and Infectious DiseasesNational Institutes of Health
Tuberculosis (TB) is one of the world’s most devastating infectious diseases. March 24th marks the day in 1882 when German microbiologist Robert Koch announced he had discovered Mycobacterium tuberculosis, the bacterium that causes this ancient scourge. Today, in recognition of World TB Day, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH)...
Source: Healthy Living - The Huffington Post - March 24, 2017 Category: Consumer Health News Source Type: news
Identification of a New HCV Subtype 6xg Among Injection Drug Users in Kachin, Myanmar
This study has several limitations. Frist, HCV exists in a quasispecies form in human body (Martell et al., 1992). It will be better to obtain a single full-length genome sequence from a single virus. However, because of failure in amplification of near full-length HCV genome (>5000 bps), we amplified and sequenced 10 overlapping HCV genomic segments to obtain the whole genome sequence. Therefore, the genomic sequences obtained in this study contain some ambiguous (or degenerate) nucleotides (quasispecies population). Second, previous studies showed that vast majority of IDUs in Yunnan, especially in the China-Myanmar bord...
Source: Frontiers in Microbiology - April 17, 2019 Category: Microbiology Source Type: research
UN Welcomes ‘Most Comprehensive Agreement Ever’ on Global Health
In conclusion, he pointed to the “profound” challenges we face, saying: “I am confident that if we continue and strengthen international co-operation and seize the opportunities already available, while creating even more opportunities, we can overcome them – together”.
‘A political choice’
Universal health coverage means all people regardless of their ability to pay, having access to the health care they need, when and where they need it, without facing financial hardship.
Congratulating world leaders, Tedros Adhanom Ghebreyesus, Director-General at the World Health Organization (WHO) told the histor...
Source: IPS Inter Press Service - Health - September 24, 2019 Category: International Medicine & Public Health Authors: External Source Tags: Development & Aid Global Headlines Health Human Rights Source Type: news
On World AIDS Day, Those Who Fought the 1980s Epidemic Find Striking Differences and Tragic Parallels in COVID-19
More than three decades after the World Health Organization (WHO) launched the first World AIDS Day on Dec. 1, 1988, the world’s leading global health organization faces another public health crisis in COVID-19. On this World AIDS Day, those who raised awareness of HIV, the virus that causes AIDS, find devastating similarities and haunting differences in America’s response to both crises.
In 1981, scientists recorded the first cases of a rare pneumonia, usually found among immunosuppressed patients, among a group of gay men in Los Angeles, and noticed more cases appearing among gay men in San Francisco and New ...
Source: TIME: Health - December 1, 2020 Category: Consumer Health News Authors: Olivia B. Waxman Tags: Uncategorized COVID-19 feature HIV/AIDS Source Type: news
Long COVID Experts and Advocates Say the Government Is Ignoring ‘ the Greatest Mass-Disabling Event in Human History ’
Dr. Ezekiel Emanuel is used to feeling like the only person in the country who still cares about COVID-19. He ignores the side-eye he gets for wearing an N95 mask at parties—a self-imposed policy that makes him “look odd” but kept him safe after a recent work dinner turned into a superspreader event. The oncologist, bioethicist, and professor at the University of Pennsylvania provides each of his students with an N95 and runs four HEPA air filters during lectures. He rolls down the windows when he gets in an Uber and goes hungry on planes so he can wear his mask the whole time. He’s given up one of ...
Source: TIME: Health - September 19, 2022 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 feature healthscienceclimate Source Type: news
50 Years of Achievements and Persistent Challenges for Biomedical and Health Informatics and John Mantas' Educational and Nursing Informatics Contributions
Stud Health Technol Inform. 2022 Oct 26;300:1-11. doi: 10.3233/SHTI220936.ABSTRACTBiomedical and Health Informatics (BMHI) have been essential catalysts for achievements in medical research and healthcare applications over the past 50 years. These include increasingly sophisticated information systems and data bases for documentation and processing, standardization of biomedical data, nomenclatures, and vocabularies to assist with large scale literature indexing and text analysis for information retrieval, and methods for computationally modeling and analyzing research and clinical data. Statistical and AI techniques for d...
Source: Studies in Health Technology and Informatics - October 27, 2022 Category: Information Technology Authors: Casimir A Kulikowski Source Type: research
