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Total 1208 results found since Jan 2013.
FOXM1 Contributes to Chemotherapy Sensitivity in Cervical Cancer by Regulating TTK
CONCLUSIONS: FOXM1 regulated TTK and affected the therapeutic efficacy of cisplatin and paclitaxel in cervical cancer.PMID:37272088 | DOI:10.24976/Discov.Med.202335176.22
Source: Discovery Medicine - June 5, 2023 Category: Research Authors: Qing Tang Anli Xu Ying Yang Yunmei Zhang Jianan Sun Source Type: research
Combination of B7H6-siRNA and temozolomide synergistically reduces stemness and migration properties of glioblastoma cancer cells
This study aimed to understand the potential role and molecular mechanism of the combination therapy of B7H6-siRNA and temozolomide in glioblastoma cancer. U87 cells were treated with B7H6-siRNA and temozolomide, separately and in combination. Cell viability, stemness, cell migration, and apoptosis were measured. The results of this work presented the synergistic effect of B7H6-siRNA and temozolomide in inhibiting the cancerous features of the U87 cell line. Down-regulating B7H6-siRNA expression inhibited the cell viability of U87 glioblastoma cancer cells and increased their sensitivity to temozolomide. In addition, a not...
Source: Experimental Cell Research - May 29, 2023 Category: Cytology Authors: Nadia Allahyarzadeh Khiabani Mohammad Amin Doustvandi Fateme Mohammadnejad Elnaz Salmani Hassan Kohal Neda Boushehri Mahdi Jafarlou Behzad Baradaran Source Type: research
Core-shell tecto dendrimer-mediated cooperative chemoimmunotherapy of breast cancer
J Control Release. 2023 May 16:S0168-3659(23)00334-6. doi: 10.1016/j.jconrel.2023.05.021. Online ahead of print.ABSTRACTDevelopment of effective nanomedicines to deal with tumor immunogenicity and immunosuppression is vital to improve the immunotherapy efficacy. Herein, we developed a programmed strategy not only to activate the tumoral immune microenvironment through immunogenic cell death (ICD) effect but also to promote the maturation of dendritic cells (DCs) in lymph nodes through two modules of core-shell tecto dendrimer (CSTD)-based nanomedicines. The CSTDs with amplified tumor enhanced permeability and retention eff...
Source: Cancer Control - May 18, 2023 Category: Cancer & Oncology Authors: Cong Song Mengsi Zhan Zhijun Ouyang Yuge Yao Yue Gao Mingwu Shen Xiangyang Shi Source Type: research
Reduction of SIRT1-Mediated Epigenetic Upregulation of Nav1.7 Contributes to Oxaliplatin-Induced Neuropathic Pain
CONCLUSIONS: These findings suggest that reduction of SIRT1-mediated epigenetic upregulation of Nav1.7 in the DRG contributes to the development of oxaliplatin-induced neuropathic pain in rats. The intrathecal drug delivery treatment of activating SIRT1 might be a novel therapeutic option for oxaliplatin-induced neuropathic pain.PMID:37192244
Source: Pain Physician - May 16, 2023 Category: Anesthesiology Authors: Ling-Jun Xu Jing Wang Gui-Dan Li Kai-Feng Shen Xing-Hui He Wei Wu Cui-Cui Liu Source Type: research
Multidrug resistance protein 1 silencing in osteosarcoma and chondrosarcoma cell lines
CONCLUSION: Lipofectamine 2000 was the least toxic transfection reagent in osteo- and chondrosarcoma. Successful siRNA-induced MDR1 mRNA silencing of over 80% was achieved.PMID:37148005 | DOI:10.4103/jcrt.JCRT_565_19
Source: Cell Research - May 6, 2023 Category: Cytology Authors: Sarah S Freund Michael M Bendtsen Akmal Safwat Peter H Joergensen Source Type: research
Integrating machine learning and single-cell trajectories to analyze T-cell exhaustion to predict prognosis and immunotherapy in colon cancer patients
ConclusionIn this study, we systematically explored the T-cell exhaustion trajectory in COAD and developed a TES model to assess prognosis and provide guidelines for the treatment decision. This discovery gave rise to a fresh concept for novel therapeutic procedures for the clinical treatment of COAD.
Source: Frontiers in Immunology - May 3, 2023 Category: Allergy & Immunology Source Type: research
High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer
CONCLUSION: High levels of RRN3 expression are associated with poor prognosis and cancer malignancy, such as proliferation, invasion ability, and chemosensitivity in pancreatic cancer. RRN3 targeting with anticancer drugs may be a promising therapeutic strategy to overcome refractory pancreatic cancer.PMID:37119370 | DOI:10.1007/s10147-023-02342-w
Source: Cancer Control - April 29, 2023 Category: Cancer & Oncology Authors: Chingunjav Batbayar Norihiro Ishii Norifumi Harimoto Takehiko Yokobori Hideyuki Saito Dolgormaa Gantumur Navchaa Gombodorj Bilguun Erkhem-Ochir Ryo Muranushi Kouki Hoshino Takahiro Yamanaka Kei Hagiwara Mariko Tsukagoshi Akira Watanabe Kenichiro Araki Yas Source Type: research
TRIM4 Expression Related to Malignant Progression and Cisplatin Resistance in Osteosarcoma
This study explored the role of TRIM4 in OS chemotherapy sensitivity and malignant progression. The expression of TRIM4 in OS tissues and cells was examined by RT-qPCR, immunohistochemical staining, and western blot. Specific siRNA was transfected into U2-OS and SAOS2 cells to target TRIM4. Cell biological behavior was examined by CCK-8, Transwell, and flow cytometry experiments. Cisplatin-resistant SAOS2 (SAOS2-Cis-R) cells were established, and the effect of TRIM4 expression on the cisplatin response of SAOS2 cells was tested. Knockdown of TRIM4 significantly inhibited the proliferation, migration, and invasion of U2-OS ...
Source: Applied Biochemistry and Biotechnology - April 28, 2023 Category: Biochemistry Authors: Yan Li Jie Gao Dong Wang Zijin Liu Huawu Zhang Source Type: research
Effects of Vinblastine and Vincristine on the function of chronic myeloid leukemic cells through expression of A20 and CYLD
In conclusion, the up-regulation of A20 by Vinc could involve inhibitory effects on the proliferation and survival of K562 cells. The events might contribute to the anticancer effect of Vinc on A20-sensitive CML cells.PMID:37114273 | DOI:10.14715/cmb/2022.68.10.7
Source: Mol Biol Cell - April 28, 2023 Category: Molecular Biology Authors: Nguyen Huy Hoang Nguyen Thanh Huyen Do Thi Trang Nguyen Xuan Canh Can Van Mao Mentor Sopjani Nguyen Ba Vuong Nguyen Thi Xuan Source Type: research
