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Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling.
CONCLUSION: Curcumin induced apoptosis and G0/G1 arrest in DU-145 cells by down regulating Notch signaling. PMID: 27657825 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2016 Category: Drugs & Pharmacology Authors: Sha J, Li J, Wang W, Pan L, Cheng J, Li L, Zhao H, Lin W Tags: Biomed Pharmacother Source Type: research

Nanoparticle-mediated co-delivery of chemotherapeutic agent and siRNA for combination cancer therapy
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Source: Expert Opinion on Drug Delivery - July 5, 2016 Category: Drugs & Pharmacology Authors: Bo Xiao Lijun Ma Didier Merlin Source Type: research

RNAi-combined nano-chemotherapeutics to tackle resistant tumors.
Abstract The merger of nanotechnology and combination chemotherapy has shown notable promise in the therapy of resistant tumors. The latest scientific attention encompasses the engagement of anticancer drugs in combination with small interfering (si)RNAs, such as VEGF, XLAP, PGP, MRP-1, BCL-2 and cMyc, to name but a few. siRNAs have shown immense promise to knockout drug resistance genes as well as to recover the sensitivity of resistant tumors to anticancer therapy. The nanotechnology approach could also protect siRNA against RNAse degradation as well as prevent off-target effects. In this article, we discuss the...
Source: Drug Discovery Today - July 1, 2016 Category: Drugs & Pharmacology Authors: Tekade RK, Tekade M, Kesharwani P Tags: Drug Discov Today Source Type: research

In vivo synergistic antitumor effect and safety of siRNA and lonidamine dual-loaded hierarchical targeted nanoparticles
Publication date: 15 June 2016 Source:International Journal of Pharmaceutics, Volume 506, Issues 1–2 Author(s): Bing-Feng Zhang, Lei Xing, Jian-Bin Qiao, Peng-Fei Cui, Feng-Zhen Wang, Jia-Liang Zhang, Cheng-Xiong Xu, Hu-Lin Jiang Based on development of nano-delivery system, co-delivery of chemotherapeutic drug and small interfering RNA (siRNA) has exerted a promising advantage in cancer therapy. In this work, the superiority of synergistic therapy and safety of the hierarchical targeted co-delivery system loaded with siRNA and lonidamine (LND) were evaluated. The in vivo tumor accumulation ability and cancer g...
Source: International Journal of Pharmaceutics - April 29, 2016 Category: Drugs & Pharmacology Source Type: research

Dual stimulus of hyperthermia and intracellular redox environment triggered release of siRNA for tumor-specific therapy
This study demonstrates that the constructed vesicle in combination with hyperthermia could greatly improve the in vivo stability of siRNA-CPPs and synergistically enhance its cancer therapy efficiency. Graphical abstract
Source: International Journal of Pharmaceutics - April 27, 2016 Category: Drugs & Pharmacology Source Type: research

USP4 promotes invasion of breast cancer cells via Relaxin/TGF-β1/Smad2/MMP-9 signal.
CONCLUSIONS: Therapies targeting the USP4 inhibits invasion of breast cancer cells via Relaxin/TGF-β1/Smad2/MMP-9 signal. These results indicate that USP4 is an attractive target for breast cancer therapy. PMID: 27049265 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 8, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Retinoid N-(1H-benzodimidazol-2-yl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide induces p21-dependent senescence in breast cancer cells
Publication date: Available online 17 February 2016 Source:Steroids Author(s): Mine Mumcuoglu, A. Selen Gurkan-Alp, Erdem Buyukbingol, Rengul Cetin-Atalay Retinoids have been implicated as pharmacological agents for the prevention and treatment of various types of cancers, including breast cancers. We analysed 27 newly synthesized retinoids for their bioactivity on breast, liver, and colon cancer cells. Majority of the retinoids demonstrated selective bioactivity on breast cancer cells. Retinoid 17 had a significant inhibitory activity (IC50 3.5 μM) only on breast cancer cells while no growth inhibition observed wit...
Source: Steroids - February 19, 2016 Category: Drugs & Pharmacology Source Type: research

PEGylated siRNA lipoplexes for silencing of BLIMP-1 in Primary Effusion Lymphoma: In vitro evidences of antitumoral activity.
In this study we aim to develop pegylated siRNA lipoplexes formed using the cationic lipid DOTAP and DSPE-PEG2000, capable to effectively stabilize anti Blimp-1 siRNA and suitable for systemic administration. Two types of pegylated lipoplexes using a classic (C-PEG Lipoplexes) or a post-pegylation method (P-PEG-Lipoplexes) were formulated and compared in their physicochemical properties (size, zeta potential, morphology and structure) and efficiency on PEL cell lines. A stable siRNAs protection was obtained with post pegylation approach (2% molar of DSPE-PEG2000 respect to lipid) resulting in structures with diameters of 3...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 25, 2015 Category: Drugs & Pharmacology Authors: Belletti D, Tosi G, Forni F, Lagreca I, Barozzi P, Pederzoli F, Vandelli MA, Riva G, Luppi M, Ruozi B Tags: Eur J Pharm Biopharm Source Type: research

Effect of siRNA pre-Exposure on Subsequent Response to siRNA Therapy
Conclusions Human cancer cells responded to repeat siRNA nanoparticles in a similar fashion after a temporary initial alteration and little, if any, resistance was evident against repeated siRNA treatments.
Source: Pharmaceutical Research - November 4, 2015 Category: Drugs & Pharmacology Source Type: research

The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.
CONCLUSIONS: Our findings indicated that SIRT6 inhibited the proliferation of ovarian cancer cells through down-regulation of Notch 3 expression, and might provide novel therapeutic targets for ovarian cancer therapy. PMID: 25807436 [PubMed - indexed for MEDLINE]
Source: Pharmacological Reviews - October 26, 2015 Category: Drugs & Pharmacology Authors: Zhang J, Yin XJ, Xu CJ, Ning YX, Chen M, Zhang H, Chen SF, Yao LQ Tags: Eur Rev Med Pharmacol Sci Source Type: research

Image-Guided Nanoparticle-Based siRNA Delivery for Cancer Therapy.
Abstract With the discovery of RNA interference technology, small-interfering RNA (siRNA) has emerged as new powerful tool for gene therapy because of its high targeting specificity and selectivity. However, one of the limitations to successful gene therapy is the inability to monitor delivery of genes and therapeutic responses at the targeted site. Hence, a combinatorial approach of gene therapy with molecular imaging has been crucial in optimizing gene therapy. Recent advances in nanotechnology have made tremendous efforts to develop multifunctional nanoparticles that contain imaging and therapeutic agents toget...
Source: Current Pharmaceutical Design - October 23, 2015 Category: Drugs & Pharmacology Authors: Tekade RK, Maheshwari RG, Sharma PA, Tekade M, Chauhan AS Tags: Curr Pharm Des Source Type: research

Preclinical and clinical development of siRNA-based therapeutics.
Abstract Discovery of RNA interference, first in plants and C. elegans and later in mammalian cells, led to the emergence of a transformative view in biomedical research. Knowledge of the multiple actions of non-coding RNAs has truly allowed viewing DNA, RNA and proteins in novel ways. Small interfering RNAs (siRNAs) can be used as tools to study single gene function both in vitro and in vivo and are an attractive new class of therapeutics, especially against undruggable targets for the treatment of cancer and other diseases. Despite the potential of siRNAs in cancer therapy, many challenges remain, including rapi...
Source: Advanced Drug Delivery Reviews - February 6, 2015 Category: Drugs & Pharmacology Authors: Ozcan G, Ozpolat B, Coleman RL, Sood AK, Lopez-Berestein G Tags: Adv Drug Deliv Rev Source Type: research

Cluster of Differentiation 44 Targeted Hyaluronic Acid Based Nanoparticles for MDR1 siRNA Delivery to Overcome Drug Resistance in Ovarian Cancer
Conclusions These findings suggest that this CD44 targeted HA-PEI/HA-PEG nanoparticle platform may be a clinicaly relevant gene delivery system for systemic siRNA-based anticancer therapeutics for the treatment of MDR cancers.
Source: Pharmaceutical Research - December 17, 2014 Category: Drugs & Pharmacology Source Type: research

The enhancement of gene silencing efficiency with chitosan-coated liposome formulations of siRNAs targeting HIF-1α and VEGF
Publication date: 15 January 2015 Source:International Journal of Pharmaceutics, Volume 478, Issue 1 Author(s): Emine Şalva , Suna Özbaş Turan , Fatih Eren , Jülide Akbuğa RNA interference (RNAi) holds considerable promise as a novel therapeutic strategy in the silencing of disease-causing genes. The development of effective delivery systems is important for the use of small interfering RNA (siRNA) as therapy. In the present study, we investigated the effect on breast cancer cell lines and the co-delivery of liposomes containing siHIF1-α and siVEGF. In order to achieve the co-delivery of siHIF1-α and siVEGF and to...
Source: International Journal of Pharmaceutics - November 24, 2014 Category: Drugs & Pharmacology Source Type: research

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