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Ebolavirus: Comparison of Survivor Immunology and Animal Models in the Search for a Correlate of Protection
Ebola viruses are enveloped, single-stranded RNA viruses belonging to the Filoviridae family and can cause Ebola virus disease (EVD), a serious haemorrhagic illness with up to 90% mortality. The disease was first detected in Zaire (currently the Democratic Republic of Congo) in 1976. Since its discovery, Ebola virus has caused sporadic outbreaks in Africa and was responsible for the largest 2013–2016 EVD epidemic in West Africa, which resulted in more than 28,600 cases and over 11,300 deaths. This epidemic strengthened international scientific efforts to contain the virus and develop therapeutics and vaccines. Immunology...
Source: Frontiers in Immunology - February 19, 2021 Category: Allergy & Immunology Source Type: research

Plague vaccines: new developments in an ongoing search
Appl Microbiol Biotechnol. 2021 Jun 18. doi: 10.1007/s00253-021-11389-6. Online ahead of print.ABSTRACTAs the reality of pandemic threats challenges humanity, exemplified during the ongoing SARS-CoV-2 infections, the development of vaccines targeting these etiological agents of disease has become increasingly critical. Of paramount concern are novel and reemerging pathogens that could trigger such events, including the plague bacterium Yersinia pestis. Y. pestis is responsible for more human deaths than any other known pathogen and exists globally in endemic regions of the world, including the four corners region and North...
Source: Applied Microbiology and Biotechnology - June 18, 2021 Category: Microbiology Authors: Jason A Rosenzweig Emily K Hendrix Ashok K Chopra Source Type: research

A new approach to biosecurity education: “Barn Smarts for Biosecurity: Tips for Keeping Your Horse Safe and Healthy”
Engaging the average horse owner in biosecurity education has always been challenging. Several common misconceptions pervade the equine community. Among these are the belief that it ’s an uninteresting topic, that vaccinations alone are enough to protect their horse, that biosecurity isn’t a concern for the “normal” horse, or that biosecurity practices are too difficult and expensive to implement. This pilot survey was designed to determine if incorporating memorable an d “doable” biosecurity tips for horse owners from the “The Informed Arizona Equestrian Series: Barn Smarts for Biosecurity” publication and...
Source: Journal of Equine Veterinary Science - May 1, 2017 Category: Veterinary Research Authors: E.A. Greene, A.D. Wright Source Type: research

Forget ChatGPT: The Greatest Tech Breakthrough Would Be Getting Cell Phones to Rural Women
A cell phone gives rural women access to financial services, training, networks, and, importantly, information and knowledge. Credit: Prashanth Vishwanathan (CCAFS)By Nicoline de HaanNAIROBI, Kenya, Mar 6 2023 (IPS) While 100 million people worldwide are using the AI chatbot ChatGPT to get ahead on homework and try out for top jobs at Google, more than 370 million women in developing countries lack the services of a simple cell phone. The world may be witnessing a quantum leap in the digital revolution, but cell phones and mobile internet would give these women enough of a foothold to access unprecedented opportunities to...
Source: IPS Inter Press Service - Health - March 6, 2023 Category: International Medicine & Public Health Authors: Nicoline de Haan Tags: Africa Climate Change Development & Aid Education Food and Agriculture Food Security and Nutrition Gender Global Headlines Health Inequality Innovation TerraViva United Nations IPS UN Bureau Source Type: news

Replacement of Trypsin by Proteases for Medical Applications
CONCLUSIONS: The obtained results suggested that microbial proteases can be used as safe and efficient alternatives to trypsin in cell culture in biopharmaceutical applications.PMID:36942066 | PMC:PMC10024315 | DOI:10.5812/ijpr-126328
Source: Cell Research - March 21, 2023 Category: Cytology Authors: Alireza Matinfar Mehrouz Dezfulian Nooshin Haghighipour Mehran Kurdtabar Ahmad Ali Pourbabaei Source Type: research

Blood Trials: Transfusions, Injections, and Experiments in Africa, 1890-1920.
Abstract From about 1880 to 1920, a culture of medical experimentation promoted blood transfusion as a therapy for severe anemia in Europe, which was applied in German East Africa in 1892 for a case of blackwater fever, a complication of malaria afflicting mainly Europeans. This first case of blood transfusion in Africa, in which an African's blood was transfused into a German official, complicates the dominant narrative that blood transfusions in Africa came only after World War I. Medical researchers moreover experimented with blood serum therapies on human and animal subjects in Europe and Africa, injecting blo...
Source: Medical History - October 29, 2015 Category: History of Medicine Authors: Sunseri T Tags: J Hist Med Allied Sci Source Type: research

Knowledge of medical faculty students concerning ebola in malatya, turkey.
KNOWLEDGE OF MEDICAL FACULTY STUDENTS CONCERNING EBOLA IN MALATYA, TURKEY. Southeast Asian J Trop Med Public Health. 2016 May;47(3):424-33 Authors: Ozer A, Gokce A, Seyitoglu DC Abstract The purpose of this study was to determine the knowledge levels of Inonu University medical faculty students regarding Ebola. This descriptive, cross sectional study was conducted between November and December, 2014 at Inonu University Medical Faculty. After the researchers performed the literature review, a questionnaire comprising 39 questions was prepared, and the students were asked to fill them out. Nine hundred a...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - July 16, 2016 Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research

Top 10 Mesothelioma News Stories of 2017
Every year, mesothelioma specialists and researchers make strides to advance the standard of care, improve treatment strategies and develop new diagnostic practices. Mesothelioma remains a rare cancer, with an estimated 3,000 people diagnosed each year in the U.S., but the fight to find a cure only grows stronger. And while researchers are busy finding breakthroughs in care, advocates are hard at work campaigning for a ban on asbestos, the main cause of mesothelioma. This was a memorable year on both fronts. Immunotherapy continues to be the hot topic among emerging treatments. Drugs such as pembrolizumab (Keytruda) and ni...
Source: Asbestos and Mesothelioma News - December 22, 2017 Category: Environmental Health Authors: Daniel King Tags: canada asbestos ban Food and Drug Administration Furthering Asbestos Claims Transparency Act keytruda Medical marijuana mesothelioma mesothelioma vaccine Opdivo Scott Pruitt talcum powder lawsuit yervoy Source Type: news

Viruses, Vol. 14, Pages 2291: Natural History of Marburg Virus Infection to Support Medical Countermeasure Development
This study will be instrumental in the design and development of medical countermeasures to Marburg virus disease.
Source: Viruses - October 18, 2022 Category: Virology Authors: Comer Brasel Massey Beasley Cirimotich Sanford Chou Niemuth Novak Sabourin Merchlinsky Long Stavale Wolfe Tags: Article Source Type: research

Bird flu researchers get green light to continue work on engineered virus
A voluntary moratorium on research involving lab-created versions of the H5N1 bird flu virus has been liftedResearch on lab-engineered strains of the H5N1 bird flu virus is set to restart a year after the scientists voluntarily paused it to allow for an international public debate on the safest way to proceed.Last year, two teams of scientists in the United States and the Netherlands submitted papers for publication in Science and Nature describing how they had engineered the H5N1 bird flu virus – which kills half of the people it infects but cannot naturally transmit from person to person – to spread more easily betwe...
Source: Guardian Unlimited Science - January 23, 2013 Category: Science Authors: Alok Jha Tags: Bird flu Genetics Biology World news Infectious diseases Health guardian.co.uk Medical research Microbiology Society Controversies in science Source Type: news

Scientists concerned at H7N9 bird flu outbreak that has killed 24 people
• Virus killing a fifth of those infected in China• World Health Organisation considers it a serious threatScientists are seriously concerned about a new bird flu virus that is causing severe disease in China, killing a fifth of all those it infects.So far, the virus, known as H7N9, is being transmitted only to humans from chickens, but there are worries that it could mutate into a form that could be passed from one person to another. Five mutations are known to be necessary for that to happen – H7N9 already has two of them. If that occurred, it could spread worldwide with lethal effect.According to the World Health ...
Source: Guardian Unlimited Science - May 1, 2013 Category: Science Authors: Sarah Boseley Tags: Bird flu Asia Pacific World news Infectious diseases Health guardian.co.uk Medical research Microbiology China Editorial Science Source Type: news

Ethics: the questions posed by our bionic bodies | Observer editorial
Science is sending us towards a posthuman future. We need to decide if that's where we should be goingIn the cult 1970s television show, The Six Million Dollar Man, astronaut Steve Austin (Lee Majors) is shown crash-landing on Earth, then being whisked into an operating theatre. "Gentleman, we have the capability to make the world's first bionic man," intones the narrator over the opening credits. "Steve Austin will be that man… Better, stronger, faster."Today, as our profile in the New Review of Bertolt Meyer, a young Swiss man whose life has been transformed by a £30,000 prosthetic device, shows, this bionic future is...
Source: Guardian Unlimited Science - June 15, 2013 Category: Science Authors: Observer editorial Tags: Biology Health Medical research Nanotechnology Society Ageing The Observer Science Editorials Comment is free Source Type: news

Flu research may lead to universal vaccine
Conclusion This research has identified that CD8+ T-cells are linked with protection against different strains of influenza. They are also linked with reduced severity of flu. The authors note that current vaccines that use inactivated forms of the flu virus protect against specific strains, and do not induce a strong maintained T-cell response. They suggest that, in light of their findings, this may be the reason why they produce limited protection across different subtypes of influenza virus. They say that further testing is needed to see if the live vaccines being used are better at producing cross-subtype protection, ...
Source: NHS News Feed - September 23, 2013 Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news