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Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1 α and LDHA.
CONCLUSIONS: We show that under standard culture conditions, the HIF1α-lactate dehydrogenase A axis is aberrantly upregulated in hPSC-CMs, preventing their metabolic maturation. Chemical or siRNA inhibition of this pathway results in an appropriate metabolic shift from aerobic glycolysis to oxidative phosphorylation. This in turn improves metabolic and functional maturation of hPSC-CMs. These findings provide key insight into molecular control of hPSC-CMs' metabolism and may be used to generate more physiologically mature cardiomyocytes for drug screening, disease modeling, and therapeutic purposes. PMID: 30355156 [PubMed - in process]
Source: Circulation Research - October 12, 2018 Category: Cardiology Authors: Hu D, Linders A, Yamak A, Correia C, Kijlstra JD, Garakani A, Xiao L, Milan DJ, van der Meer P, Serra M, Alves PM, Domian IJ Tags: Circ Res Source Type: research

S1P-S1PR2 Axis Mediates Homing of Muse Cells into Damaged Heart for Long Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction.
Conclusions: Muse cells may provide reparative effects and robust functional recovery, and may thus provide a novel strategy for the treatment of AMI. PMID: 29475983 [PubMed - as supplied by publisher]
Source: Circulation Research - February 23, 2018 Category: Cardiology Authors: Yamada Y, Wakao S, Kushida Y, Minatoguchi S, Mikami A, Higashi K, Baba S, Shigemoto T, Kuroda Y, Kanamori H, Amin M, Kawasaki M, Nishigaki K, Taoka M, Isobe T, Muramatsu C, Dezawa M, Minatoguchi S Tags: Circ Res Source Type: research

High-Throughput RNAi Screening Identifies a Role for the Osteopontin Pathway in Proliferation and Migration of Human Aortic Smooth Muscle Cells
Conclusions A phenotypic high-throughput siRNA screen could be applied to identify genes relevant for the cell biology of HaoSMCs. Novel genes were identified which play a role in proliferation, apoptosis, mitosis and migration of HaoSMCs. These may represent potential drug candidates in the future.
Source: Cardiovascular Drugs and Therapy - April 18, 2016 Category: Cardiology Source Type: research

PANCR, the PITX2 Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression Original Articles
Conclusions— PANCR and PITX2c are coordinately expressed early during cardiomyocyte differentiation from stem cells. PANCR knockdown decreased PITX2c expression in differentiated cardiomyocytes, altering the transcriptome in a manner similar to PITX2c knockdown.
Source: Circulation: Arrhythmia and Electrophysiology - January 18, 2016 Category: Cardiology Authors: Gore-Panter, S. R., Hsu, J., Barnard, J., Moravec, C. S., Van Wagoner, D. R., Chung, M. K., Smith, J. D. Tags: Arrhythmias, Atrial Fibrillation, Gene Expression & Regulation, Functional Genomics Original Articles Source Type: research

Cytoprotection of Baicalein Against Oxidative Stress-induced Cardiomyocytes Injury Through the Nrf2/Keap1 Pathway
Abstract:Baicalein is one of the major flavonoids found in the root of Scutellaria baicalensis Georgi. Previous studies suggest that baicalein displays protective effect on experimental cardiac models in vitro and in vivo. However, the mode of action remains unclear. Here, we showed that baicalein conferred cardioprotective effect against oxidative stress-induced cell injury in H9c2 cells and human embryonic stem cells-derived cardiomyocytes. Immunoprecipitation with anti-NF-E2–related factor 2 (Nrf2) antibody in baicalein-treated cells demonstrated that baicalein effectively disrupted the association between Nrf2 and Ke...
Source: Journal of Cardiovascular Pharmacology - January 1, 2015 Category: Cardiology Tags: Original Article Source Type: research

Anti-Inflammatory Peptides From Cardiac Progenitors Ameliorate Dysfunction After Myocardial Infarction Heart Failure
Conclusions Soluble JAM-A secreted from cardiac progenitor cells reduces infiltration of neutrophils after myocardial infarction and ameliorates tissue damage through prevention of excess inflammation. Our finding may lead to a new therapy for cardiovascular disease by using the anti-inflammatory effect of JAM-A.
Source: JAHA:Journal of the American Heart Association - December 2, 2014 Category: Cardiology Authors: Liu, M.-L., Nagai, T., Tokunaga, M., Iwanaga, K., Matsuura, K., Takahashi, T., Kanda, M., Kondo, N., Naito, A. T., Komuro, I., Kobayashi, Y. Tags: Heart Failure Source Type: research

Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity
Conclusion The up-regulation of SphK1 and S1P-dependent pathways is critical for the angiogenic/vasculogenic activity of ECFCs. The identification of this pathway provides attractive targets to optimize cell-based therapy for revascularization in ischaemic diseases.
Source: Cardiovascular Research - June 20, 2014 Category: Cardiology Authors: Poitevin, S., Cussac, D., Leroyer, A. S., Albinet, V., Sarlon-Bartoli, G., Guillet, B., Hubert, L., Andrieu-Abadie, N., Couderc, B., Parini, A., Dignat-George, F., Sabatier, F. Tags: Vascular biology Source Type: research

Hypoxia Inhibits Cellular Senescence to Restore the Therapeutic Potential of Old Human Endothelial Progenitor Cells via the Hypoxia-Inducible Factor-1α-TWIST-p21 Axis.
CONCLUSIONS: This study introduces ex vivo expansion protocols involving hypoxic preconditioning that are suitable for efficiently expanding old EPCs without senescence through modulation of the hypoxia-induced hypoxia-inducible factor-1α-TWIST-p21 axis. In addition, the expanded cells are shown to be useful for therapeutic vasculogenesis. PMID: 23928864 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 8, 2013 Category: Cardiology Authors: Lee SH, Lee JH, Yoo SY, Hur J, Kim HS, Kwon SM Tags: Arterioscler Thromb Vasc Biol Source Type: research

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