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Total 29 results found since Jan 2013.

Insights into siRNA transfection in suspension: Efficient gene silencing in human mesenchymal stem cells encapsulated in hyaluronic acid hydrogel.
Abstract Small interfering RNAs (siRNAs) are powerful tools for post-transcriptional gene silencing which offers enormous opportunities for tissue engineering applications. However, poor serum stability, inefficient intracellular delivery, and inevitable toxicity of transfection reagents are the key barriers for their clinical translation. Thus innovative strategies that allow safe and efficient intracellular delivery of the nucleic acid drugs at the desired site is urgently needed for a smooth clinical translation of therapeutically appealing siRNA-based technology. In this regard, we have developed an innovative...
Source: Biomacromolecules - January 14, 2019 Category: Biochemistry Authors: Paidikondala M, Nawale GN, Varghese OP Tags: Biomacromolecules Source Type: research

Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
In conclusion, DRIAs inhibit cellular proliferation in endometriosis, thus representing a potential therapeutic option for the management of endometriosis.
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 11, 2018 Category: Biochemistry Source Type: research

ILK regulates MSCs survival and angiogenesis partially through AKT and mTOR signaling pathways.
This study examined the role and mechanism of ILK in MSCs survival and angiogenesis. In hypoxic condition, upregulation of ILK expression increased the phosphorylation of Akt and mTOR, resulting in markedly enchanced MSCs survival and VEGF expression; while significantly inhibited MSCs survival and VEGF expression was detected in MSCs with ILK kinase inactivation, which was associated with a reduction of phosphorylation of Akt and mTOR. In addition, it also caused an inhibitory effects of ILK on MSCs survival and VEGF expression, which was abolished by Akt or mTOR inhibitor. Furthermore, it was observed that ILK-overexpres...
Source: Acta Histochemica - April 28, 2017 Category: Biochemistry Authors: Zeng B, Liu L, Wang S, Dai Z Tags: Acta Histochem Source Type: research

Antitumor and chemosensitizing action of 3-bromopyruvate: Implication of deregulated metabolism
Publication date: Available online 19 April 2017 Source:Chemico-Biological Interactions Author(s): Saveg Yadav, Shrish Kumar Pandey, Ajay Kumar, Praveen Kumar Kujur, Rana Pratap Singh, Sukh Mahendra Singh 3-Bromopyruvate (3-BP), brominated derivative of pyruvate, possesses strong antitumor potential, owing to its ability to inhibit multiple target molecules crucial for survival of neoplastic cells. Although, 3-BP displays cytotoxicity against a wide variety of tumors, there is no report with respect to malignancies of thymic origin. Therefore, we investigated its antineoplastic action in vitro against tumor cells of a mur...
Source: Chemico Biological Interactions - April 19, 2017 Category: Biochemistry Source Type: research

Angiopoietin ‐2 Enhances Osteogenic Differentiation of Bone Marrow Stem Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - February 17, 2017 Category: Biochemistry Authors: Mi ‐Lan Kang, Eun‐Ah Kim, Se‐Young Jeong, Gun‐Il Im Tags: Article Source Type: research

ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - June 22, 2016 Category: Biochemistry Authors: Satoru Onizuka, Takanori Iwata, Sung‐Joon Park, Kenta Nakai, Masayuki Yamato, Teruo Okano, Yuichi Izumi Tags: Article Source Type: research

Adipose-Derived Mesenchymal Stem Cells Transplantation Alleviates Renal Injury in Streptozotocin-Induced Diabetic Nephropathy
This study may provide evidence for the treatment of DN using ADMSCs.
Source: Journal of Histochemistry and Cytochemistry - October 25, 2015 Category: Biochemistry Authors: Ni, W., Fang, Y., Xie, L., Liu, X., Shan, W., Zeng, R., Liu, J., Liu, X. Tags: Articles Source Type: research

BK virus infection activates the TNFα/TNF receptor system in Polyomavirus-associated nephropathy.
Abstract Polyomavirus-associated nephropathy due to BK virus infection (BKVAN) is recognized as an important cause of significant kidney transplant dysfunction often leading to renal graft loss. The activation of innate immune defense mechanisms during BKVAN is still poorly understood and an altered regulation of inflammatory mediators by resident kidney cells upon viral infection can be expected to contribute to the onset and progression of disease. TNFα interacting with its receptors, TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), is largely accepted to be involved in viral responses, exhibiting both proinf...
Source: Molecular and Cellular Biochemistry - October 7, 2015 Category: Biochemistry Authors: Ribeiro A, Merkle M, Motamedi N, Nitschko H, Köppel S, Wörnle M Tags: Mol Cell Biochem Source Type: research

WEHI-3 cells inhibit adipocyte differentiation in 3T3-L1 cells.
Abstract By investigating the anti-adipogenic effects of WEHI-3 cells - a murine acute myelomonocytic leukemia cell line - we sought to improve the efficiency of hematopoietic stem cell transplantation (HSCT). Analysis of Oil Red O staining and the expression of adipogenic genes, including PPARγ, C/EBPα, FAS and LPL, indicated that WEHI-3 cells significantly inhibited 3T3-L1 mouse preadipocyte cells from differentiating into adipocytes. In vivo, fat vacuoles in mice injected with WEHI-3 cells were also remarkably reduced in the murine bone marrow pimelosis model. Moreover, the key gene in the Rho signaling path...
Source: Biochemical and Biophysical Research communications - April 21, 2015 Category: Biochemistry Authors: Lai J, Liu G, Yan G, He D, Zhou Y, Chen S Tags: Biochem Biophys Res Commun Source Type: research

Upregulation of Fas in epithelial ovarian cancer reverses the development of resistance to Cisplatin.
In conclusion, our findings suggested that Fas might act as a promising therapeutic target for improvement of the sensibility to Cisplatin in ovarian cancer. PMID: 24755555 [PubMed - as supplied by publisher]
Source: BMB Reports - April 23, 2014 Category: Biochemistry Authors: Yang F, Long W, Xuechuan H, Xueqin L, Hongyun M, Yonghui D Tags: BMB Rep Source Type: research

Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway.
Abstract Recent studies have shown that allogeneic bone marrow (BM)-mesenchymal stem cell transplantation (MSCT) appears to be effective in systemic lupus erythematosus (SLE) patients and lupus-prone mice, contrary to studies in syngeneic BM-MSCT. These studies indicated that the abnormalities of BM-MSCs may be involved in the pathogenesis of SLE. Our studies and other previous studies have revealed that BM-MSCs from SLE patients exhibited early signs of senescence, such as flattened morphology, slow proliferation, increased senescence-associated β-galactosidase (SA-β-gal) activity, and so on. However, the mecha...
Source: Molecular and Cellular Biochemistry - October 16, 2013 Category: Biochemistry Authors: Gu Z, Tan W, Feng G, Meng Y, Shen B, Liu H, Cheng C Tags: Mol Cell Biochem Source Type: research

Activation of PRMT1 and PRMT5 mediates hypoxia- and ischemia-induced apoptosis in human lung epithelial cells and the lung of miniature pigs: The role of p38 and JNK mitogen-activated protein kinases.
This study examined the role of hypoxia in PRMT activation in A549 human lung epithelial cells, as well as the role of ischemia in PRMT activation in the lung of miniature pigs. In A459 cells, hypoxia increased the expression of PRMT1 and PRMT5, and overexpression of PRMT1 and PRMT5 induced apoptosis. The transfection of PRMT1 and PRMT5 small interfering RNA (siRNA) prevented hypoxia-inducible factor (HIF)-1α expression and apoptosis in A549 cells. Hypoxia-induced expression of PRMT1 and PRMT5 was blocked by p38 and JNK mitogen-activated protein kinase (MAPK) inhibitors, but not by an inhibitor of extracellular signal-reg...
Source: Biochemical and Biophysical Research communications - October 9, 2013 Category: Biochemistry Authors: Lim SK, Jeong YW, Kim DI, Park MJ, Choi JH, Kim SU, Kang SS, Han HJ, Park SH Tags: Biochem Biophys Res Commun Source Type: research