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Procedure: Kidney Transplant
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Genetically Modified Pig ’s Heart Is Transplanted Into a Second Patient
The first patient to receive such an organ died after two months. “At least now I have hope,” the second recipient said before the surgery.
Source: NYT Health - September 22, 2023 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: your-feed-science Kidneys Genetic Engineering Pigs Heart Immune System Transplants Surgery and Surgeons University of Maryland Medical Center Source Type: news
News at a glance: Diphtheria vaccine shortage, prisoner release, and iNaturalist ’s growth
CONSERVATION
Popular biodiversity app to expand
The nonprofit that runs iNaturalist, a popular app and website for identifying species, has received a $10 million grant to expand. The funding from the Gordon and Betty Moore Foundation, announced last week, will allow iNaturalist—whose website is one of the largest generators of crowd-sourced species-occurrence data—to add users, technology, and observations to inform conservation. iNaturalist hopes to grow in nature-rich parts of the world, such as Asia and South America, which have fewer users uploading data. Since iNaturalist’s founding in 2008, the ...
Source: Science of Aging Knowledge Environment - September 21, 2023 Category: Geriatrics Source Type: research
News at a glance: Diphtheria treatment shortage, prisoner release, and iNaturalist ’s growth
CONSERVATION
Popular biodiversity app to expand
The nonprofit that runs iNaturalist, a popular app and website for identifying species, has received a $10 million grant to expand. The funding from the Gordon and Betty Moore Foundation, announced last week, will allow iNaturalist—whose website is one of the largest generators of crowd-sourced species-occurrence data—to add users, technology, and observations to inform conservation. iNaturalist hopes to grow in nature-rich parts of the world, such as Asia and South America, which have fewer users uploading data. Since iNaturalist’s founding in 2008, the ...
Source: ScienceNOW - September 21, 2023 Category: Science Source Type: news
The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials
Am J Physiol Renal Physiol. 2023 Sep 21. doi: 10.1152/ajprenal.00152.2023. Online ahead of print.ABSTRACTPatients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease. This increased risk cannot be fully explained by traditional risk factors such as hypertension. Endothelial dysfunction and arterial stiffness have been suggested as factors which explain some of the increased risk, and are independently associated with important cardiovascular outcomes in CKD patients. Studies in other disease populations have shown positive effects of exercise on vascular dysfunction. The aim of this review was...
Source: Am J Physiol Renal P... - September 21, 2023 Category: Urology & Nephrology Authors: Mark D Davies Felicity Hughes Aamer Sandoo Abdulfattah Alejmi Jamie Hugo Macdonald Source Type: research
Development of a nomogram for the prediction of acute kidney injury after liver transplantation: a model based on clinical parameters and postoperative cystatin C level
CONCLUSION: The model based on combinations of clinical parameters and postoperative cystatin C levels had a higher predictive performance for post-LT AKI than the model based on clinical parameters or postoperative cystatin C level alone. Additionally, we developed an easy-to-use nomogram based on the final model, which could aid in the early detection of AKI and improve the prognosis of patients after LT.PMID:37734410 | DOI:10.1080/07853890.2023.2259410
Source: Annals of Medicine - September 21, 2023 Category: Internal Medicine Authors: Zhipeng Wu Yi Wang Li He Boxun Jin Qinwei Yao Guangming Li Xin Wang Yingmin Ma Source Type: research
Durable complete response to early immunotherapy discontinuation in a kidney transplant recipient with advanced cutaneous squamous cell carcinoma: A case report and review of literature
CONCLUSION: Organ transplant recipients with complete response to immunotherapy for cutaneous squamous cell carcinoma may continue to respond despite early treatment cessation. This may reduce the risks of late immune-related adverse events and acute graft rejection.PMID:37734447 | DOI:10.1016/j.trim.2023.101932
Source: Transplant Immunology - September 21, 2023 Category: Transplant Surgery Authors: Ziyao Lu Mohammed Afzal Keisuke Shirai Source Type: research
Cost-effectiveness of terlipressin for hepatorenal syndrome: The United States hospital perspective
CONCLUSIONS: HRS patients treated with terlipressin experienced better clinical outcomes and a lower cost per treatment response vs alternative treatments. ICU days and pharmacy costs were key cost drivers distinguishing the treatment groups. These outcomes suggest that terlipressin is cost-effective on the basis of total cost per response achieved.PMID:37729445 | DOI:10.1080/13696998.2023.2260693
Source: Journal of Medical Economics - September 20, 2023 Category: Health Management Authors: John A Carter Xingyue Huang Khurram Jamil Shelby Corman Varun Ektare John Niewoehner Source Type: research
Diagnosis and treatment of glomerular diseases with a membranoproliferative glomerulonephritis (MPGN) pattern of injury
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):688-695. doi: 10.1007/s00508-023-02264-7. Epub 2023 Sep 20.ABSTRACTMembranoproliferative glomerulonephritis (MPGN) represents a heterogeneous group of diseases. The common feature of a membranoproliferative lesion pattern in the kidney biopsy can either be idiopathic/primary or-much more frequently-have a secondary cause. The historical classification into MPGN types I to III has largely been abandoned and replaced in recent years by a pathogenesis-oriented classification. A MPGN with C1q, C3 and/or C4 deposits on light microscopy is referred to as immune complex GN (IC-GN), whil...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Michael Rudnicki Martin Windpessl Kathrin Eller Balazs Odler Philipp Gauckler Irmgard Neumann Emanuel Zitt Heinz Regele Andreas Kronbichler Karl Lhotta Marcus D S äemann Source Type: research
Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers
CONCLUSIONS: Physicians appear to consider the recipient characteristics that inform expected post-transplant survival score when deciding whether to accept a marginal kidney for a given recipient.PMID:37729938 | DOI:10.2215/CJN.0000000000000302
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 20, 2023 Category: Urology & Nephrology Authors: Juan M Gonzalez Sepulveda Sanjay Mehrotra Jui-Chen Yang Karolina J Schantz Yolanda Becker Richard Formica Daniela P Ladner Dixon Kaufman John Friedewald Source Type: research
Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation
We present two cases of live-related donor kidney transplants (LDKTs) with low-MFI pre-transplant DSA values who experienced an early acute antibody-mediated rejection (ABMR) as a result of an anamnestic antibody response by DSA against HLA class II antibodies. These results were confirmed by retesting of both pre-transplant and post-transplant archived sera from patients as well as freshly obtained donor cells. Our examples indicate a possible ABMR in patients with low MFI pre-transplant DSA. Reclassification of low vs. high-risk may be appropriate for some patients with low-MFI DSA."PMID:37730185 | DOI:10.1016/j.trim.2023.101931
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Rajni Chauhan Aseem Kumar Tiwari Geet Aggarwal L Gowri Suresh Mohit Kumar Shyam Bihari Bansal Source Type: research
Association between blood transfusion after kidney transplantation and risk for the development of de novo HLA donor-specific antibodies and poor clinical outcomes: A single-center retrospective study
CONCLUSIONS: Our study showed that blood transfusion after transplantation is associated with the occurrence of de novo DSAs increasing an immunological risk for poor clinical outcomes for kidney transplantation recipients.PMID:37730183 | DOI:10.1016/j.trim.2023.101930
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Zhong-Yu Kang Chun Liu Wei Liu Daihong Li Source Type: research
Experiences of Indigenous Patients Receiving Dialysis: Systematic Review of Qualitative Studies
CONCLUSIONS: Indigenous patients receiving dialysis experience inequities in healthcare which compounds existing accessibility issues caused by colonization. Improving the accessibility and cultural responsiveness of dialysis and kidney transplant services in collaboration with Indigenous stakeholders holds promise to enhance the experience of Indigenous patients receiving dialysis.PMID:37730171 | DOI:10.1053/j.ajkd.2023.07.014
Source: Rural Remote Health - September 20, 2023 Category: Rural Health Authors: Marianne Kerr Allison Jaure Jacqueline H Stephens Siah Kim Richard Cutler Brydee Cashmore Michelle Dickson Nicole Evangelidis Jaquelyne T Hughes Ieyesha Roberts Nicole Scholes-Robertson Victoria Sinka GradDip Jonathan C Craig Source Type: research
Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation
We present two cases of live-related donor kidney transplants (LDKTs) with low-MFI pre-transplant DSA values who experienced an early acute antibody-mediated rejection (ABMR) as a result of an anamnestic antibody response by DSA against HLA class II antibodies. These results were confirmed by retesting of both pre-transplant and post-transplant archived sera from patients as well as freshly obtained donor cells. Our examples indicate a possible ABMR in patients with low MFI pre-transplant DSA. Reclassification of low vs. high-risk may be appropriate for some patients with low-MFI DSA."PMID:37730185 | DOI:10.1016/j.trim.2023.101931
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Rajni Chauhan Aseem Kumar Tiwari Geet Aggarwal L Gowri Suresh Mohit Kumar Shyam Bihari Bansal Source Type: research
Association between blood transfusion after kidney transplantation and risk for the development of de novo HLA donor-specific antibodies and poor clinical outcomes: A single-center retrospective study
CONCLUSIONS: Our study showed that blood transfusion after transplantation is associated with the occurrence of de novo DSAs increasing an immunological risk for poor clinical outcomes for kidney transplantation recipients.PMID:37730183 | DOI:10.1016/j.trim.2023.101930
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Zhong-Yu Kang Chun Liu Wei Liu Daihong Li Source Type: research
