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Viruses, Vol. 12, Pages 450: A Mouse Model of Oropharyngeal Papillomavirus-Induced Neoplasia Using Novel Tools for Infection and Nasal Anesthesia
ibeault Paul F. Lambert Human head and neck cancers that develop from the squamous cells of the oropharynx (Oropharyngeal Squamous Cell Carcinomas or OPSCC) are commonly associated with the papillomavirus infection. A papillomavirus infection-based mouse model of oropharyngeal tumorigenesis would be valuable for studying the development and treatment of these tumors. We have developed an efficient system using the mouse papillomavirus (MmuPV1) to generate dysplastic oropharyngeal lesions, including tumors, in the soft palate and the base of the tongue of two immune-deficient strains of mice. To maximize efficiency an...
Source: Viruses - April 15, 2020 Category: Virology Authors: Andrea Bilger Renee E. King Josh P. Schroeder Jared T. Piette Louis A. Hinshaw Andrew D. Kurth Ronnie W. AlRamahi Matthew V. Barthel Ella T. Ward-Shaw Darya Buehler Kristyn S. Masters Susan L. Thibeault Paul F. Lambert Tags: Article Source Type: research

Nasal nitric oxide as a long ‐term monitoring and prognostic biomarker of mucosal health in chronic rhinosinusitis
Conclusion: nNO may serve as a non ‐invasive long‐term biomarker to monitor sinus disease severity and to prognosticate patients with CRS. This has implications for potential integration into clinical practice.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - April 11, 2020 Category: Allergy & Immunology Authors: Daniel J. Lee, Jonathan Yip, John M. Lee Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Endonasal instrumentation and aerosolization risk in the era of COVID ‐19: simulation, literature review, and proposed mitigation strategies
Conclusion: We confirm that aerosolization presents a  risk to the endonasal skull base surgeon. In the outpatient setting, use of a barrier significantly reduces aerosol spread. Cold surgical instrumentation and microdebrider use pose significantly less aerosolization risk than a high‐speed drill. Procedures requiring drill use should carry a sp ecial designation as an “Aerosol Generating Surgery” to convey this unique risk, and support the need for protective PPE.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - April 2, 2020 Category: Allergy & Immunology Authors: Alan D. Workman, D. Bradley Welling, Bob S. Carter, William T. Curry, Eric H. Holbrook, Stacey T. Gray, George A. Scangas, Benjamin S. Bleier Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

a case of eosinophilic gastroenteritis found by pica during oral immunotherapy.
We report the case of a 6-year-old boy with EGE. He was diagnosed as having immediate-type food allergies (egg, milk and wheat) by oral food challenges at 1 year of age. OIT for each food was carried out, and the amounts of the offending foods were able to be gradually increased without causing any immediate-type allergy symptoms. However, the total IgE and specific IgE values were remarkably increased at the age of 4 years and 4 months. He first developed oral mucosa symptoms and vomiting at 4 years and 10 months of age, and they gradually worsened. Stopping eggs and milk alleviated the symptoms. Nevertheless, he still oc...
Source: Arerugi - March 20, 2020 Category: Allergy & Immunology Authors: Nishimura K, Fukuie T, Miyaji Y, Inuzuka Y, Toyokuni K, Irahara M, Ishikawa F, Sato M, Saito M, Yamamoto-Hanada K, Narita M, Nomura I, Ohya Y Tags: Arerugi Source Type: research

Topography of polyp recurrence in eosinophilic chronic rhinosinusitis
ConclusionThe frontal and ethmoid sinuses were most affected in those patients with polyp recurrence. Whether the disease is more active in this location or topical therapy has limited access requires further evaluation.
Source: International Forum of Allergy and Rhinology - March 2, 2020 Category: Allergy & Immunology Authors: Jessica W. Grayson, William Li, Jacqueline Ho, Raquel Alvarado, Janet Rimmer, William A. Sewell, Richard J. Harvey Tags: ORIGINAL ARTICLE Source Type: research

Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies
AbstractThe upper airways (UA) should be considered as a functional unit. Current functional anatomy divides URT in three, mutually dependent, “junction boxes”: i) the ostio-meatal complex (OMC), ii) the spheno-ethmoidal recess (SER), and iii) the rhinopharynx (RP). Correct ventilation and effective mucociliary clearance of these sites significantly affect the healthy physiology of the entire respiratory system. The OMC, SER, and RP ob struction is the first pathogenic step in the inflammatory/infectious cascade of UA disorders. The inflammation of the respiratory mucosa is the main pathogenic factor for airway obstruc...
Source: Italian Journal of Pediatrics - February 9, 2020 Category: Pediatrics Source Type: research

Quality ‐of‐life and olfaction changes observed with short‐term medical management of chronic rhinosinusitis
ConclusionsParticipants with varied impacts of CRS, treated with individualized short ‐term AMT, demonstrated significant improvements in CRS‐ and olfactory‐specific QOL measures, without corresponding improvement in clinically measured olfactory function. Olfactory function changes moderately correlated with endoscopy score changes, but lacked an association with QOL measureme nts.
Source: International Forum of Allergy and Rhinology - February 4, 2020 Category: Allergy & Immunology Authors: Andrew J. Thomas, Jess C. Mace, Vijay R. Ramakrishnan, Jeremiah A. Alt, Jose L. Mattos, Rodney J. Schlosser, Zachary M. Soler, Timothy L. Smith Tags: ORIGINAL ARTICLE Source Type: research

The association of penicillin allergy with outcomes after open  ventral hernia repair
ConclusionPA patients had more comorbidities and complex ventral hernias. When controlling for contamination and MRSA history, BLP is associated with improved outcomes particularly in contaminated cases. PA may be a risk factor for patient complexity, and further studies are warranted to determine if allergy testing can be warranted in known or anticipated contaminated cases.Graphic abstract
Source: Surgical Endoscopy - February 2, 2020 Category: Surgery Source Type: research

Capsule Endoscopy Useful for Evaluating Equivocal Celiac Disease Capsule Endoscopy Useful for Evaluating Equivocal Celiac Disease
Small-bowel capsule endoscopy (SBCE) is useful for evaluating patients with equivocal celiac disease, researchers in the UK report.Reuters Health Information
Source: Medscape Allergy Headlines - January 29, 2020 Category: Allergy & Immunology Tags: Gastroenterology News Source Type: news

Measuring Success in the Treatment of Patients with Chronic Rhinosinusitis
Chronic rhinosinusitis (CRS) has a substantial impact on patients ’ quality of life (QOL). Among the many metrics available for measuring treatment success in CRS, patient-reported outcome measures that quantify changes in QOL are the most widely used methods. In addition, objective data from imaging, endoscopy, and olfactory testing are useful adjunct measures to diagnose and prevent progression of disease, although these metrics have mixed correlations with symptoms and QOL. In the future, molecular biology, and multiomics techniques may change how successful CRS treatment is defined.
Source: Immunology and Allergy Clinics of North America - January 21, 2020 Category: Allergy & Immunology Authors: Naweed Chowdhury, Timothy L. Smith, Daniel M. Beswick Source Type: research

Use of mucosal eosinophil count as a guide in the management of chronic rhinosinusitis
ConclusionMEC correlates with objective clinical disease severity and may guide aggressiveness of management for the individual patient.
Source: International Forum of Allergy and Rhinology - January 11, 2020 Category: Allergy & Immunology Authors: Daniel Sharbel, Mingsi Li, Aykut A. Unsal, Sandra Y. Tadros, Jason Lee, Paul Biddinger, Thomas Holmes, Stilianos E. Kountakis Tags: ORIGINAL ARTICLE Source Type: research

Controlled delivery of ciprofloxacin and ivacaftor via sinus stent in a preclinical model of Pseudomonas sinusitis
ConclusionThe CISS had robust clinical efficacy in treatingP aeruginosa rabbit sinusitis. The innovative design of double ‐layered drug coating on the surface of the biodegradable stent may provide therapeutic advantages over current treatment strategies forP aeruginosa sinusitis.
Source: International Forum of Allergy and Rhinology - December 22, 2019 Category: Allergy & Immunology Authors: Dong ‐Jin Lim, Justin McCormick, Daniel Skinner, Shaoyan Zhang, Jeffrey B. Elder, John G. McLemore, Mark Allen, John Martin West, Jessica W. Grayson, Steven M. Rowe, Bradford A. Woodworth, Do‐Yeon Cho Tags: ORIGINAL ARTICLE Source Type: research

A comparison of international clinical practice guidelines on adult chronic rhinosinusitis shows considerable variability of recommendations for diagnosis and treatment
ConclusionWe performed an extensive search and included ten (inter)national guidelines on CRS for adults. According to AGREE II, five were of good or sufficient quality. Overall, there was much variation between guidelines in recommended diagnostic test or treatment, direction of evidence and GoR. We found consensus for nasal endoscopy, CT scan, allergy testing and intranasal steroids. We argue for standardization of guideline development, to increase their quality and improve comparability.
Source: European Archives of Oto-Rhino-Laryngology - December 15, 2019 Category: ENT & OMF Source Type: research

Approaches and Challenges to Management of Pediatric and Adult Patients With Eosinophilic Esophagitis
Treatment of eosinophilic esophagitis (EoE) has progressed from elemental formula for children and esophageal dilation for adults to selective exclusion of food triggers and swallowed topical corticosteroids. Management guidelines are available from the American Gastroenterological Association and the Joint Task Force on Allergy Immunology Practice Parameters. We cannot, however, evaluate the efficacy of treatments without a definition of response. We propose a treat to target approach, based on symptoms and findings from endoscopy and histology.
Source: Gastroenterology - December 9, 2019 Category: Gastroenterology Authors: Ikuo Hirano, Glenn T. Furuta Source Type: research