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Total 1303 results found since Jan 2013.

Specific Clinical and Immunological Changes Following Mesenchymal Stem Cell Transplantation in COVID-19-induced Acute Respiratory Distress Syndrome Patients: A Phase-I Clinical Trial
This study evaluated the safety and efficacy of three times transplantation of umbilical cord-derived MSCs (UC-MSCs) in terms of specific immunological and clinical changes in mild-to-moderate COVID-19-induced ARDS patients. In this single-center, open-label, phase 1 clinical trial, 20 patients diagnosed with COVID-19 and mild-to-moderate ARDS were included and were divided into two groups: a control group receiving standard care and an intervention group receiving UC-MSC in addition to standard care. Three consecutive intravenous transplants of UC-MSC (1× cells/kg body weight per each transplant) were performed in the in...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Najmeh Kaffash Farkhad Alireza Sedaghat Hamidreza Reihani Amir Adhami Moghadam Ahmad Bagheri Moghadam Nayereh Khadem Ghaebi Mohammad Ali Khodadoust Amin Reza Nikpoor Jalil Tavakol Afshari Source Type: research

Immunological consequences of microbiome-based therapeutics
The complex network of microscopic organisms living on and within humans, collectively referred to as the microbiome, produce wide array of biologically active molecules that shape our health. Disruption of the microbiome is associated with susceptibility to a range of diseases such as cancer, diabetes, allergy, obesity, and infection. A new series of next-generation microbiome-based therapies are being developed to treat these diseases by transplanting bacteria or bacterial-derived byproducts into a diseased individual to reset the recipient’s microbiome and restore health. Microbiome transplantation therapy is still in...
Source: Frontiers in Immunology - January 12, 2023 Category: Allergy & Immunology Source Type: research

Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients
Transplanted SCID patients without B-cell reconstitution are at risk of developing late-onset hepatitis related to a chronic enteric viral infection (norovirus/sapovirus/human Aichi virus) and associated with effector memory CD8+ T cells expansion.
Source: Journal of Allergy and Clinical Immunology - January 9, 2023 Category: Allergy & Immunology Authors: Quentin Riller, Jacques Fourgeaud, Julie Bruneau, Suk See De Ravin, Grace Smith, Mathieu Fusaro, Samy Meriem, Aude Magerus, Marine Luka, Ghaith Abdessalem, Ludovic Lhermitte, Anne Jamet, Emmanuelle Six, Alessandra Magnani, Martin Castelle, Romain L évy, Source Type: research

Two cases of eosinophilic gastrointestinal disorder due to newly appearing food allergies after cord blood transplantation
Transpl Immunol. 2023 Jan 2;77:101781. doi: 10.1016/j.trim.2022.101781. Online ahead of print.ABSTRACTEosinophilic gastrointestinal disorders (EGIDs) are infrequent complications after allogeneic hematopoietic cell transplantation (allo-HCT). Furthermore, it is well-known that allergic diseases are transferable after allo-HCT from allergic donors to non-allergic recipients. However, the type of graft-versus host disease (GVHD) prophylaxis that leads to allergic disease transfer is unclear. Furthermore, no study has reported a case of acquired food allergy resulting in EGID that was detected based on the clinical course and...
Source: Transplant Immunology - January 5, 2023 Category: Transplant Surgery Authors: Naonori Harada Yosuke Makuuchi Masatomo Kuno Teruhito Takakuwa Hiroshi Okamura Mitsutaka Nishimoto Yasuhiro Nakashima Hideo Koh Miho Sakaida Sayaka Tanaka Yuko Kuwae Akira Higashimori Fumino Tanaka Masahiko Ohsawa Yasuhiro Fujiwara Masayuki Hino Hirohisa Source Type: research

Unraveling the role of Breg cells in digestive tract cancer and infectious immunity
Over the past two decades, regulatory B cells (Breg cells or Bregs) have emerged as an immunosuppressive subset of B lymphocytes playing a key role in inflammation, infection, allergy, transplantation, and cancer. However, the involvement of Bregs in various pathological conditions of the gastrointestinal tract is not fully understood and is the subject of much recent research. In this review, we aimed to summarize the current state of knowledge about the origin, phenotype, and suppressive mechanisms of Bregs. The relationship between the host gut microbiota and the function of Bregs in the context of the disturbance of mu...
Source: Frontiers in Immunology - December 23, 2022 Category: Allergy & Immunology Source Type: research

Science ’s 2022 Breakthrough of the Year: A telescope’s golden eye sees the universe anew
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Source: ScienceNOW - December 15, 2022 Category: Science Source Type: news

Upper airway microbiome transplantation for patients with chronic rhinosinusitis
ConclusionsNasal microbiome transplants obtained from healthy individuals and administered as nasal lavages to patients with CRSsNP are feasible. The patients reported significant and lasting reduction of symptoms and these findings were associated with a lasting increase in abundance and diversity of the local bacterial flora. The observations, which need to be confirmed by randomized controlled trials, may constitute a new treatment avenue for these difficult to treat patients where antibiotics only provides short lasting symptom control.Trial registration number: NCT03122795.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - December 14, 2022 Category: Allergy & Immunology Authors: Anders M årtensson, Charlotte Cervin‐Hoberg, Flavia Huygens, Malin Lindstedt, Christina Sakellariou, Lennart Greiff, Anders Cervin Tags: ORIGINAL ARTICLE Source Type: research

Clinical immunology: literature review 2022
Clinical Immunology articles presented at the Literature Review course at the 2022 annual meeting of the American College of Allergy, Asthma, and Immunology encompassing exciting updates on a wide range of clinical immunology topics. These included the diagnosis and management of secondary hypogammaglobulinemia and chronic granulomatous disease (CGD), risk factors for complications in patients with humoral immunodeficiency, the current landscape of challenges and use of T cell receptor excision circles (TRECs) newborn screening, treatment outcomes for patients with athymia treated with thymic implants, patients with inborn...
Source: Annals of Allergy, Asthma and Immunology - November 30, 2022 Category: Allergy & Immunology Authors: Jennifer Heimall Tags: Editorial Source Type: research