Filtered By:
Vaccination: Meningitis Vaccine

This page shows you your search results in order of relevance. This is page number 3.

Order by Relevance | Date

Total 126 results found since Jan 2013.

Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for TP53 Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia
Discussion This case demonstrates successful cure of pre-B-ALL complicating XLA by alloSCT with restoration of B-cell development and functional antibody response. We are aware of only one previous case of pre-B-ALL in an XLA patient (21), which suggests that human BTK deficiency in itself does not predispose to pre-B-ALL. However, there are data to suggest that BTK may act as a tumor suppressor, and BTK deficiency may predispose to tumor development following a “second hit.” Mice with a genetic deficiency in Slp65, a gene encoding an adaptor protein that functions together with BTK, have a block in proge...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Richard A. Insel, M.D.
JDRF Chief Scientific OfficerRichard A. Insel, M.D., oversees the research strategy of JDRF, the world’s largest funder of type 1 diabetes (T1D) research. Prior to joining JDRF in 2003, Dr. Insel was the founding director of the Center for Human Genetics and Molecular Pediatric Disease and professor of pediatrics and microbiology and immunology at the University of Rochester Medical Center. During his 26-year affiliation with the university’s medical center, he served as the acting chair of pediatrics, director of the Strong Children’s Research Center, and chief of the division of pediatric immunology, allergy, and r...
Source: PHRMA - February 14, 2014 Category: Pharmaceuticals Authors: Julie Source Type: news

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections.
Abstract We characterized 121 adults with frequent or severe bacterial respiratory tract infections at diagnosis of selective subnormal IgG3. Mean age was 47±13 (SD)y; 87.6% were women. Associated disorders included: autoimmune conditions 33.1%; hypothyroidism 14.9%; atopy 29.8%; and other allergy manifestations 41.3%. In 34.1%, proportions of protective Streptococcus pneumoniae serotype-specific IgG levels did not increase after polyvalent pneumococcal polysaccharide vaccination. Blood CD19+, CD3+/CD4+, CD3+/CD8+, and CD56+/CD16+ lymphocyte levels were within reference limits in most patients. In regression anal...
Source: Cellular Immunology - September 14, 2015 Category: Allergy & Immunology Authors: Barton JC, Bertoli LF, Barton JC, Acton RT Tags: Cell Immunol Source Type: research

Selective Subnormal IgG1 in 54 Adult Index Patients with Frequent or Severe Bacterial Respiratory Tract Infections.
Authors: Barton JC, Bertoli LF, Barton JC, Acton RT Abstract We characterized 54 adult index patients with reports of frequent or severe bacterial respiratory tract infections at diagnosis of selective subnormal IgG1. Mean age was 50 ± 13 (SD) y; 87.0% were women. Associated disorders included the following: autoimmune conditions 50.0%; hypothyroidism 24.1%; atopy 38.9%; and other allergy 31.5%. In 35.5%, proportions of protective S. pneumoniae serotype-specific IgG levels did not increase after polyvalent pneumococcal polysaccharide vaccination (PPPV). Blood lymphocyte subset levels were within reference limits i...
Source: Journal of Immunology Research - April 30, 2016 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology
Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. Introduction Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influen...
Source: Frontiers in cellular and infection microbiology - April 16, 2019 Category: Microbiology Source Type: research

Otitis Media: Rapid Evidence Review.
Abstract Acute otitis media (AOM) is the most common diagnosis in childhood acute sick visits. By three years of age, 50% to 85% of children will have at least one episode of AOM. Symptoms may include ear pain (rubbing, tugging, or holding the ear may be a sign of pain), fever, irritability, otorrhea, anorexia, and sometimes vomiting or lethargy. AOM is diagnosed in symptomatic children with moderate to severe bulging of the tympanic membrane or new-onset otorrhea not caused by acute otitis externa, and in children with mild bulging and either recent-onset ear pain (less than 48 hours) or intense erythema of the t...
Source: American Family Physician - September 14, 2019 Category: Primary Care Authors: Gaddey HL, Wright MT, Nelson TN Tags: Am Fam Physician Source Type: research

Oral and topical antibiotic prescriptions for children in general practice
Conclusions One in six children received at least one oral antibiotic prescription per year during 2000–2010. While topical prescription rates steadily increased during 2005–2010 and remained stable during 2006–2010, prescription rates for oral antibiotics increased significantly during the period 2000–2005 and then significantly decreased during the period 2006–2010. As clinical guidelines remained the same over this period, the effects could be contributed to the initiation of the Dutch nationwide pneumococcal vaccination campaign in 2006.
Source: Archives of Disease in Childhood - February 14, 2013 Category: Pediatrics Authors: de Bont, E. G. P. M., van Loo, I. H. M., Dukers-Muijrers, N. H. T. M., Hoebe, C. J. P. A., Bruggeman, C. A., Dinant, G.-J., Cals, J. W. L. Tags: ADC Paediatric and Perinatal Drug Therapy, Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Child health, Asthma, Guidelines Source Type: research

Comparison of antiallergic effects of pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine in a murine model of allergic rhinitis
Conclusion and Clinical RelevanceBoth PV and PCV suppressed the allergen‐specific T helper 2 response and induced regulatory T cells in a murine model of allergic rhinitis. However, PV and PCV may activate Treg cells via different mechanisms. Level of EvidenceN/A. Laryngoscope, 2013
Source: The Laryngoscope - February 16, 2013 Category: ENT & OMF Authors: Boo‐Young Kim, Ji‐Hyeon Shin, Hyang Rim Park, Sung Won Kim, Soo Whan Kim Tags: Allergy/Rhinology Source Type: research

Adolescents need a booster of serogroup C meningococcal vaccine to protect them and maintain population control of the disease
The serogroup C meningococcal immunisation programme was reviewed during 2012 by the Department of Health's Joint Committee on Vaccination and Immunisation (JCVI), and an adolescent booster has been recommended as a result of concerns over duration of immunity in the childhood population.1 During the 1990s, a clone of Neisseria meningitidis (sequence type 11; ST11) with a serogroup C polysaccharide capsule (repeating units of the sugar, α-2-9 N acetyl neuraminic acid) swept through the UK causing outbreaks of meningococcal disease in schools and universities, generating considerable media attention and anxiety for pa...
Source: Archives of Disease in Childhood - March 11, 2013 Category: Pediatrics Authors: Pollard, A. J., Green, C., Sadarangani, M., Snape, M. D. Tags: Smoking and tobacco, Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Adolescent health, Child health, Health education, Homicide, Health promotion, Smoking Leading article Source Type: research

Question 2 * Is there a role for MRI as an adjunct for diagnosing bacterial meningitis?
Scenario You are asked to consult on a 3-week-old neonate who was admitted for a ‘full septic screen’. He had a lumbar puncture several hours after starting antibiotics. The lumbar puncture was traumatic and revealed pleocytosis (increased red and white cells). Cultures remained sterile after 72 h, but there was concern that the antibiotics had caused a false negative culture result. You wonder if in this scenario MRI would be useful to aid diagnosis of meningitis. Structured clinical question In a 3-week-old neonate with suspected meningitis [patient], does MRI [intervention] assist in the diagnosis of ba...
Source: Archives of Disease in Childhood - April 12, 2013 Category: Pediatrics Authors: Upadhyayula, S. Tags: ADC Archimedes, Immunology (including allergy), Drugs: infectious diseases, Meningitis, Vaccination / immunisation, Infection (neurology) Source Type: research

Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B
Streptococcus pneumoniae is a major human pathogen responsible for a spectrum of diseases, including pneumonia, meningitis, and sepsis. Morbidity and mortality linked to pneumococcal disease remain high in sub-Saharan Africa, despite the introduction of protein-polysaccharide conjugate vaccines (PCVs), which offer protection against major disease-causing serotypes. PCVs are limited in their affordability and their efficacy in high-risk groups, such as infants. Furthermore, because the conjugate vaccine is limited in its serotype coverage, the major disease-causing serotypes are being replaced by previously minor serotypes ...
Source: Journal of Allergy and Clinical Immunology - December 20, 2012 Category: Allergy & Immunology Authors: Daniel R. Neill, Sarah Smeaton, Mathieu Bangert, Aras Kadioglu Tags: Letters to the Editor Source Type: research

Anti-TNF treatment blocks the induction of T cell-dependent humoral responses
Conclusions These data indicate that TNF blockade severely impedes the induction of primary TD humoral responses, probably by interfering with the germinal centre reaction.
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Franco Salinas, G., De Rycke, L., Barendregt, B., Paramarta, J. E., Hreggvidstdottir, H., Cantaert, T., van der Burg, M., Tak, P. P., Baeten, D. Tags: Open access, Genetics, Immunology (including allergy), Biological agents, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes Basic and translational research Source Type: research

Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tocilizumab therapy
Conclusions TCZ does not impair PPV23 immunogenicity in RA patients, whereas antibody responses may be reduced when TCZ is used as a combination therapy with MTX.
Source: Annals of the Rheumatic Diseases - July 4, 2013 Category: Rheumatology Authors: Mori, S., Ueki, Y., Akeda, Y., Hirakata, N., Oribe, M., Shiohira, Y., Hidaka, T., Oishi, K. Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Physicians' gut feeling is useful in diagnosing serious infection in children
Commentary on: Van den Bruel A, Thompson M, Buntinx F, et al.. Clinicians’ gut feeling about serious infections in children: observational study. BMJ 2012;345:e6144. Context With the advent of effective vaccinations, serious infections (SI) have become rare among children presenting to primary care settings, yet when not diagnosed promptly, such infections, especially meningitis and septic shock, can cause substantial morbidity and mortality. Hence, researchers continue to search for new diagnostic methods; the present study by Van den Bruel and colleagues investigates the basis and value of gut feeling or intuition ...
Source: Evidence-Based Medicine - July 5, 2013 Category: Internal Medicine Authors: Mittal, M. K. Tags: Infection (gastroenterology), EBM Prognosis, Epidemiologic studies, General practice / family medicine, Immunology (including allergy), Meningitis, Pneumonia (infectious disease), Vaccination / immunisation, Infection (neurology), Renal medicine, Pneumoni Source Type: research