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Total 83 results found since Jan 2013.

Advances in Sinus Surgery for Nasal Polyps
CONCLUSION: Surgical intervention remains a mainstay of therapy for CRSwNP. Newer techniques revolve around improving access for topical steroid therapy.PMID:36848271 | DOI:10.1177/19458924221147783
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: T Graham Norwood Jessica W Grayson Bradford A Woodworth Source Type: research

State of the Art Medical Management of Nasal Polyps
CONCLUSIONS: Topical steroid therapy is clearly effective for CRSwNP, and recent studies demonstrate the safety and efficacy of high-dose nasal steroid rinses. Alternate delivery methods for local steroids may be useful for patients who are not responding to or who are noncompliant with conventional intranasal corticosteroid sprays and rinses. Future studies are needed to clarify if oral or topical antibiotics, oral anti-leukotrienes, or other novel therapies are significantly effective in decreasing symptoms and improving the quality of life in patients with CRSwNP.PMID:36848283 | DOI:10.1177/19458924221145256
Source: American Journal of Rhinology and Allergy - February 27, 2023 Category: ENT & OMF Authors: Kelly L Staricha Hawa M Ali Janalee K Stokken Source Type: research

Cross allergic reactions in infants and toddlers with atopic dermatitis.
Conclusion: In children up to 3 years with atopic dermatitis and sensitization to plant pollen, the role of a pollen-food allergy syndrome must be taken into account in the pathogenesis of the disease. In children with cross sensitization, the course of atopic dermatitis is more severe; the symptoms from the respiratory and digestive system co-exist. The positive family history is a factor, predisposing to the development of cross sensitization in infants and toddlers. PMID: 24176963 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - October 30, 2013 Category: Biomedical Science Authors: Cudowska B, Kaczmarski M, Wasilewska J Tags: Adv Med Sci Source Type: research

Overlapping biological drugs prescription status: real life in Genoa
Conclusion: This study involving selected patients with severe asthma underlines the possible overlap in the choice of biological treatments. With the current lack of a reliable biomarker that orient us towards a more precise use of these drugs, so far a detailed clinical history and objective examination remain central. Despite this approach could be, now suitable, in the near future it will be no longer sufficient, the identification of a single, or a panel of biomarkers, would be mandatory.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Bagnasco, D., Aloe', T., Bondavalli, T., Testino, E., Manfredi, A., Passalacqua, G. Tags: Clinical Problems Source Type: research

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Blood eosinophil counts rarely reflect airway eosinophilia in children with severe asthma
ConclusionsPeripheral blood counts are not reliable in characterising airway inflammation in severe asthmatic children exposed to high dose steroid therapy, therefore bronchoscopy with BAL should be considered.
Source: Allergy - January 25, 2013 Category: Allergy & Immunology Authors: N. Ullmann, C. J. Bossley, L. Fleming, M. Silvestri, A. Bush, S. Saglani Tags: Brief Communication Source Type: research

Relevance of gad antibodies in adults with epilepsy: experience in a tertiary clinic
Conclusion Our experience suggests that GAD antibodies are present in a significant number of patients with adult onset epilepsy, especially those with other autoimmune disorders. The relevance of GAD antibodies in this setting remains unclear. The presence of OCBs and GAD antibodies within the CSF suggest a CNS based autoimmune process but the GAD antibodies themselves may be a marker of this processes rather than being directly pathogenic, as is suggested for antibodies directed against neuronal surface antigens. In our cohort immunotherapy did not improve seizure control and it may be that these antibodies are produced ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Lilleker, J., Biswas, V., Mohanraj, R. Tags: Immunology (including allergy), Brain stem / cerebellum, Cranial nerves, Drugs: CNS (not psychiatric), Epilepsy and seizures, Neuromuscular disease, Peripheral nerve disease, Ophthalmology, Radiology, Connective tissue disease, Musculoskeletal syndromes, Source Type: research

Republished: Recent advances in autoimmune pancreatitis: type 1 and type 2
Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis characterised clinically by frequent presentation with obstructive jaundice, histologically by a lymphoplasmacytic infiltrate with fibrosis, and therapeutically by a dramatic response to steroids. When so defined, AIP can be sub-classified into two subtypes, 1 and 2. Recent international consensus diagnostic criteria for AIP have been developed for diagnosis of both forms of AIP. Type 1 AIP is the pancreatic manifestation of a multiorgan disease, recently named IgG4-related disease. Little is known about the pathogenesis of either form of AIP. Despite frequent...
Source: Postgraduate Medical Journal - December 11, 2013 Category: Journals (General) Authors: Kamisawa, T., Chari, S. T., Lerch, M. M., Kim, M.-H., Gress, T. M., Shimosegawa, T. Tags: GUT Recent advances in clinical practice, Pancreas and biliary tract, Pancreatitis, Immunology (including allergy) Republished recent advances in clinical practice Source Type: research

Treatment dependence in chronic inflammatory demyelinating polyradiculoneuropathy: is it related to disease phenotype or to the therapy used?
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare and disabling immune neuropathy which often has a heterogeneous presentation. Patients usually improve after therapy with steroids, high-dose intravenous immunoglobulin (IVIg) or plasma exchange. Most patients require, however, a prolonged treatment to avoid deterioration. It is unclear which therapy should be first used in these patients and whether there are clues to predict for how long therapy should be continued. Rabin et al1 reviewed the data from 70 patients with CIDP who had responded to therapy and compared the clinical, electrophysiologica...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 9, 2014 Category: Neurosurgery Authors: Nobile-Orazio, E. Tags: Immunology (including allergy), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease Editorial commentaries Source Type: research

Question 2: Should steroids be used in the treatment of septic arthritis?
Scenario You are the paediatric registrar on duty when a 12-year-old boy is admitted to your ward with a strong suspicion of septic arthritis of the left knee. He plays soccer at competitive level; the boy and his parents are concerned about the long-term consequences for his playing. While you are waiting for the result of the white count of the synovial fluid to confirm the diagnosis and promptly start antibiotic therapy, you remember a recent discussion about the use of steroids in infectious disease, and so you decide to review the literature and analyse whether the use of steroids as an adjuvant therapy could improve ...
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Macchiaiolo, M., Buonuomo, P. S., Mennini, M., Villani, A., Bartuli, A. Tags: ADC Archimedes, Oncology, Football (soccer), Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Rheumatology, Trauma, Injury Source Type: research

Elevated Tryptase concentration In bronchoalveolar lavage fluid from patients with chronic eosinophilic pneumonia
Conclusion; Tryptase in BALF can be detected in patients with CEP. The tryptase-positive patients with CEP tended to relapse and have complication of asthma. Mast cell tryptase may be associated with intractable pathogenesis in CEP.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Kondo, M., Tagaya, E., Tamaoki, J. Tags: 5.3 Allergy and Immunology Source Type: research

A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study
Publication date: January 2015 Source:The Lancet Haematology, Volume 2, Issue 1 Author(s): John E Levine , Thomas M Braun , Andrew C Harris , Ernst Holler , Austin Taylor , Holly Miller , John Magenau , Daniel J Weisdorf , Vincent T Ho , Javier Bolaños-Meade , Amin M Alousi , James L M Ferrara Background Graft-versus-host disease (GVHD) is the major cause of non-relapse mortality after allogeneic haemopoietic stem-cell transplantation (SCT). The severity of symptoms at the onset of GVHD does not accurately define risk, and thus most patients are treated alike with high dose systemic corticosteroids. We aimed to define c...
Source: The Lancet Haematology - January 8, 2015 Category: Hematology Source Type: research

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