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Therapy: Immunotherapy

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Total 6127 results found since Jan 2013.

Double-blind, Placebo-controlled Food Challenge Is Essential In Primary Hazelnut Allergy Diagnosis
Birch allergy affects up to a third of Canadians (Lok et al J Asthma 2017). Cross reaction between birch pollen and certain tree nut allergens mainly hazelnut may contribute to false positive skin tests as well as pollen-food syndrome and mislabeling patients as having a life-threatening allergy to hazelnut. We aimed to determine the usefulness of double-blind, placebo-controlled food challenge (DBPCFC) in the diagnosis of primary hazelnut allergy (HA) in our oral immunotherapy study cohort.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Danbing Ke, Bruce Mazer, Duncan Lejtenyi, Liane Beaudette, Yvan St-Pierre, Sofianne Gabrielli, Julia Upton, Moshe Ben-Shoshan Source Type: research

The Role of Bile Acids in Food Allergy and Responses to Oral Immunotherapy by Metabolomic Profiling
Metabolomics is an innovative technology to interrogate disease mechanisms by measuring the sum metabolic activity of cells. Though food allergy metabolomics literature is limited, prior work suggested an association between bile acid pathways and IgE-mediated food allergy. Early data has implicated bile acids, specifically glycolithocholates, in promoting T regulatory cells (Treg) differentiation. We employed serum metabolomics to assess associations between bile acid pathways and food allergy, particularly during oral immunotherapy (OIT).
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Yamini Virkud, Rachel Kelly, Sarita Patil, Bert Ruiter, Neal Smith, Augusto Litonjua, Scott Weiss, Jessica Lasky Su, Wayne Shreffler Source Type: research

Subcutaneous and sublingual allergen-specific immunotherapy: a tale of two routes.
This article reviewed the available literature, including a large number of randomized controlled trials, meta-analyses, and real-life studies as well, on the outcomes of SCIT and SLIT concerning the treatment critical issues of the two routes, that are efficacy, safety, cost-effectiveness, and compliance to treatment. The efficacy of SCIT and SLIT is similar in respiratory allergy, providing, based on the induction of typical changes in the immunologic response, an early control of symptoms that steadily increases during the treatment and its efficacy lasts after the recommended duration of three years. Such results are t...
Source: European Annals of Allergy and Clinical Immunology - May 8, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Intralymphatic immunotherapy for mountain cedar pollinosis: A randomized, double-blind, placebo-controlled trial.
CONCLUSION: In this proof-of-concept trial, intralymphatic immunotherapy was well tolerated and reduced the symptoms and medication use associated with allergic rhinoconjunctivitis caused by mountain cedar pollen. PMID: 32407947 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 10, 2020 Category: Allergy & Immunology Authors: Thompson C, Silvers S, Shapiro M Tags: Ann Allergy Asthma Immunol Source Type: research

Food Allergy Management at School in the Era of Immunotherapy
AbstractPurpose of ReviewFood allergy is increasing in prevalence, and management focuses on strict avoidance of known allergens and appropriately treating reactions. Any reaction has the potential to result in anaphylaxis, which can be fatal. Children spend a significant amount of time in the childcare or school setting, and interactions between families, school personnel, and clinicians are important to ensure the health and safety of children with allergies and asthma.Recent FindingsThis review examines current food allergy guidelines and legislation, an assessment of allergen-free schools, the importance of written ana...
Source: Current Allergy and Asthma Reports - June 5, 2020 Category: Allergy & Immunology Source Type: research

Post-hoc Analysis of Epicutaneous Immunotherapy for Peanut Allergy Phase 3 results: Relevance for Exposure Through Restaurant Meals
Peanut allergy is the most common persistent food allergy in children and is prevalent in the US1 and other Western countries. Peanut-induced allergic reactions can be severe and sometimes (though rarely) fatal, as recently reviewed.2 Management of peanut allergy relies upon avoiding consumption of peanut and being prepared to treat possible allergic reactions from accidental exposure with rescue medication.3 The difficulty of allergen avoidance is illustrated by the observation that half of all food-allergic patients report experiencing a severe allergic reaction that required emergency department attendance, and about 1 ...
Source: Annals of Allergy, Asthma and Immunology - November 28, 2020 Category: Allergy & Immunology Authors: Benjamin C. Remington, Dianne E. Campbell, Todd D. Green, David M. Fleischer, Stef J. Koppelman Tags: Letters Source Type: research

Exploiting Nut Cross Reactivity to Facilitate Real World Treatment of Tree Nut Allergy
Oral immunotherapy (OIT) for food allergy has become increasingly common among practicing allergists1. Tree nut allergy accounts for ∼33% of food-induced anaphylaxis fatalities and only 9% outgrow their allergy2,3. Tree nut OIT has been successful4,5, but is burdened by frequent sensitization, as assessed by positive specific IgE (sIgE) or skin prick tests (SPT) to multiple nuts, often without a prior exposure history. Although allergy to each nut could be confirmed or refuted by an oral food challenge (OFC) and OIT performed to each reactive nut, such an approach is not only onerous for patients but each challenge carri...
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Richard L. Wasserman, Hugh H. Windom, Daria Lie, Deanna M. Pence, Jean Ly Tags: Letters Source Type: research

Emerging developments in the forefront of peanut oral immunotherapy
Purpose of review Despite the COVID-19 pandemic, progress continued in the field of peanut oral immunotherapy over the past 12 to 18 months. Of importance, the first oral immunotherapy product for the treatment of peanut allergy was approved by the US Food and Drug Administration in January 2020. Recent findings Suggested modifications to the practice of oral immunotherapy, some of which may have lasting impacts, were circulated as a result of the pandemic. New advances in pathophysiology, sustained unresponsiveness, quality of life, safety, and cost effectiveness were also published. Summary During 202...
Source: Current Opinion in Allergy and Clinical Immunology - April 30, 2021 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

Unusual and Unexpected Allergic Reactions Can Be Unraveled by Molecular Allergy Diagnostics
The fifth class of immunoglobulin, immunoglobulin E (IgE) was discovered in 1967 and has had immense importance for the understanding, diagnosis, and treatment of allergic disease. More than 50 years have passed and efforts to characterize, standardize, and refine allergens with the aim to improve clinical diagnosis and allergen-specific immunotherapy are still ongoing. Another important breakthrough was made in 1999 with the introduction of component-resolved diagnostics (CRD), making it possible to quantify IgE antibodies against individual allergen proteins for diagnostic purposes at a molecular level. The progress and ...
Source: International Archives of Allergy and Immunology - May 5, 2021 Category: Allergy & Immunology Source Type: research

Grass pollen allergy as an anaphylaxis cofactor during peanut oral immunotherapy
Grass pollen allergy, typically associated with non –life-threatening symptoms, such as rhinoconjunctivitis, is one of the most common allergies worldwide.1 Rarely, anaphylaxis occurs after grass pollen exposure in children.2 Oral immunotherapy (OIT) for the treatment of food allergy has been gaining popularity in the last decade as evidence on met hodology, effectiveness, and safety has progressed.3,4 Studies have revealed that patients with peanut allergy on OIT with seasonal allergic rhinitis experience dose-related adverse events more frequently with seasonal patterns.
Source: Annals of Allergy, Asthma and Immunology - May 7, 2021 Category: Allergy & Immunology Authors: Gilbert T. Chua, Edmond S. Chan, Lianne Soller, Scott B. Cameron Tags: Letters Source Type: research

Diagnosis and Management of Food Allergy
Food allergy is an immune-mediated disease and must be differentiated from other adverse effects related to food that are non –immune mediated. Symptoms of immunoglobulin (Ig) E–mediated allergy can range from mild to severe, and life-threatening anaphylaxis may occur. Current recommended strategies for diagnosis include the use of skin prick tests, allergen-specific serum IgE, and/or oral food challenges. Management e ntails allergen avoidance and appropriate treatment of allergic reactions should accidental ingestions occur. Treatment approaches under investigation include immunotherapy as well as biologics and novel...
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Roxanne Carbonell Oriel, Julie Wang Source Type: research

Characteristics of patients with spontaneous resolution of sesame allergy
The prevalence of sesame allergy is increasing; strict avoidance is the mainstay of therapy. Lately, sesame oral immunotherapy was presented as an alternative treatment, with a high rate of success. Therefore, data on the natural history and the clinical characteristics of patients with persistent sesame allergy are important for the management of patients with sesame allergy.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: Keren Mahlab-Guri, Alex Guri, Laliv Kadar, Ilan Asher, Zev Sthoeger, Daniel Elbirt, Shira Rosenberg-Bezalel Source Type: research

Updating the CoFAR Grading Scale for Systemic Allergic Reactions in Food Allergy
Immunotherapy is promising as an efficacious treatment for food allergy. Other food allergy treatments are also under development. However, adverse allergic events (AE) during treatment, as well as during oral food challenges (OFC) are common and reporting is not standardized. A more nuanced grading scale is needed to create a comprehensive and universal system to categorize AEs and their severity for food allergy clinical trials.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Sharon Chinthrajah, Stacie Jones, Edwin Kim, Scott Sicherer, Wayne Shreffler, Bruce Lanser, Negin Atri, Denise Babineau, Daniel Adelman, Ahmar Iqbal, Susan Limb, Amanda Rudman Spergel, Alkis Togias, Robert Wood Source Type: research

Personalized management for unmet needs with food allergy
Purpose of review Patients with food allergies are at risk of experiencing accidental allergic symptoms in real life. Low thresholds may be a risk factor for accidental allergic reactions. Therefore, the evaluation of this threshold is required for the management of food allergies. We have suggested a management approach to identify the threshold dose and the consumable dose, considering patient age and the severity of food allergies. Recent findings A younger age is a risk factor for accidental allergic reactions, and school-age children are likely to have a lower quality of life (QOL) than younger children. Ad...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research

The long-term effectiveness of allergy immunotherapy in subjects with asthma is associated with a lower prevalence of sleep disturbances. Results from the REACT-study
Respiratory allergy often affects the upper and lower airways as allergic rhinitis (AR) and asthma, with a negative impact on sleep. Allergy immunotherapy (AIT), particularly for house dust mite (HDM) allergy, has proven to be an effective treatment in asthma, but long-term data for AIT in asthma and sleep are sparse. The real-world effectiveness of AIT (REACT)-study was a large, retrospective German cohort study (2007-2017) with up to 9 years of follow-up. AIT was associated with long-term improved asthma control, reduced risk of asthma exacerbations and hospitalisations in patients with AR and pre-existing asthma (Fritzs...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Contoli, M., Fritzsching, B., Freemantle, N., Buchs, S., Larsen, J., Porsbjerg, C. Tags: 05.03 - Allergy and immunology Source Type: research