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Therapy: Immunotherapy

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Total 258 results found since Jan 2013.

DKK1 Affects Survival of Patients with Head and Neck Squamous Cell Carcinoma by Inducing Resistance to Radiotherapy and Immunotherapy
CONCLUSION: Our data show that DKK1 can affect both radiotherapy and immunotherapy in HNSC, suggesting that DKK1 can be a potential target for radioimmunology in HNSC.PMID:36690301 | DOI:10.1016/j.radonc.2023.109485
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 23, 2023 Category: Radiology Authors: Xinyu Ye Jingwen Liu Rencui Quan Yi Lu Jian Zhang Source Type: research

Targeting the chemokine ligand 2-chemokine receptor 2 axis provides the possibility of immunotherapy in chronic pain
Eur J Pharmacol. 2023 Mar 10:175646. doi: 10.1016/j.ejphar.2023.175646. Online ahead of print.ABSTRACTChronic pain affects patients' physical and psychological health and quality of life, entailing a tremendous public health challenge. Currently, drugs for chronic pain are usually associated with a large number of side effects and poor efficacy. Chemokines in the neuroimmune interface combine with their receptors to regulate inflammation or mediate neuroinflammation in the peripheral and central nervous system. Targeting chemokines and their receptor-mediated neuroinflammation is an effective means to treat chronic pain. I...
Source: European Journal of Pharmacology - March 12, 2023 Category: Drugs & Pharmacology Authors: Shan Liu Xiao-Bing Lan Miao-Miao Tian Chun-Hao Zhu Lin Ma Jia-Mei Yang Juan Du Ping Zheng Jian-Qiang Yu Ning Liu Source Type: research

Nanoparticles overcome adaptive immune resistance and enhance immunotherapy via targeting tumor microenvironment in lung cancer
Lung cancer is one of the common malignant cancers worldwide. Immune checkpoint inhibitor (ICI) therapy has improved survival of lung cancer patients. However, ICI therapy leads to adaptive immune resistance and displays resistance to PD-1/PD-L1 blockade in lung cancer, leading to less immune response of lung cancer patients. Tumor microenvironment (TME) is an integral tumor microenvironment, which is involved in immunotherapy resistance. Nanomedicine has been used to enhance the immunotherapy in lung cancer. In this review article, we described the association between TME and immunotherapy in lung cancer. We also highligh...
Source: Frontiers in Pharmacology - March 24, 2023 Category: Drugs & Pharmacology Source Type: research

Targeting ZDHHC9 potentiates anti-programmed death-ligand 1 immunotherapy of pancreatic cancer by modifying the tumor microenvironment
Biomed Pharmacother. 2023 Mar 22;161:114567. doi: 10.1016/j.biopha.2023.114567. Online ahead of print.ABSTRACTImmune checkpoint blockade (ICB) therapy targeting the programmed death 1/programmed death-ligand 1 (PD-1/PD-L1) axis has achieved considerable success in treating a wide range of cancers. However, most patients with pancreatic cancer remain resistant to ICB. Moreover, there is a lack of optimal biomarkers for the prediction of response to this therapy. Palmitoylation is mediated by a family of 23 S-acyltransferases, termed zinc finger Asp-His-His-Cys-type palmitoyltransferases (ZDHHC), which precisely control vari...
Source: Cancer Control - March 24, 2023 Category: Cancer & Oncology Authors: Zhiqing Lin Keke Huang Hui Guo Manli Jia Qiuqin Sun Xuhao Chen Jianmin Wu Qingqing Yao Peng Zhang Sergii Vakal Zhengzhi Zou Haiyao Gao Lei Ci Jiangfan Chen Wei Guo Source Type: research

MYC induces immunotherapy and interferon- γ resistance through downregulation of JAK2
Cancer Immunol Res. 2023 Apr 19:CIR-22-0184. doi: 10.1158/2326-6066.CIR-22-0184. Online ahead of print.ABSTRACTImmunotherapy has revolutionized the treatment of advanced melanoma. Because the pathways mediating resistance to immunotherapy are largely unknown, we conducted transcriptome profiling of pre-immunotherapy tumor biopsies from melanoma patients that received PD-1 blockade or adoptive cell therapy with tumor-infiltrating lymphocytes. We identified two melanoma-intrinsic, mutually exclusive gene programs, which were controlled by interferon-γ (IFNγ) and MYC, and the association with immunotherapy outcome. MYC-over...
Source: Cell Research - April 19, 2023 Category: Cytology Authors: Ettai Markovits Ortal Harush Erez N Baruch Eldad D Shulman Assaf Debby Orit Itzhaki Liat Anafi Artem Danilevsky Noam Shomron Guy Ben-Betzalel Nethanel Asher Ronnie Shapira-Frommer Jacob Schachter Iris Barshack Tamar Geiger Ran Elkon Michal J Besser Gal Ma Source Type: research

GSE160638 MYC induces immunotherapy and interferon- γ resistance through downregulation of JAK2
Contributors : Ettai Markovits ; Ran Elkon ; Michal J Besser ; Gal MarkelSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImmunotherapy revolutionized the treatment of advanced melanoma. As the pathways mediating resistance to immunotherapy are largely unknown, we conducted transcriptome profiling of pre-immunotherapy tumor biopsies from melanoma patients that received PD-1 blockade (n=36) or adoptive cell therapy with tumor infiltrating lymphocytes (n=37). We identified two melanoma-intrinsic mutually exclusive gene programs, which are controlled by interferon- γ and MYC, and determi...
Source: GEO: Gene Expression Omnibus - April 24, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Comprehensive Analysis of NABP2 as a Prognostic Biomarker and Its Correlation with Immune Infiltration in Hepatocellular Carcinoma
CONCLUSION: Based on these findings, NABP2 appears to be a candidate biomarker for HCC prognosis and immunotherapy.PMID:37113629 | PMC:PMC10128078 | DOI:10.2147/JIR.S403370
Source: Cell Research - April 28, 2023 Category: Cytology Authors: Bowen Li Jinghang Liu Liangzhi Xu Qi Xu Zhaohui Liu Tiande Liu Source Type: research

Integrating machine learning and single-cell trajectories to analyze T-cell exhaustion to predict prognosis and immunotherapy in colon cancer patients
ConclusionIn this study, we systematically explored the T-cell exhaustion trajectory in COAD and developed a TES model to assess prognosis and provide guidelines for the treatment decision. This discovery gave rise to a fresh concept for novel therapeutic procedures for the clinical treatment of COAD.
Source: Frontiers in Immunology - May 3, 2023 Category: Allergy & Immunology Source Type: research

Core-shell tecto dendrimer-mediated cooperative chemoimmunotherapy of breast cancer
J Control Release. 2023 May 16:S0168-3659(23)00334-6. doi: 10.1016/j.jconrel.2023.05.021. Online ahead of print.ABSTRACTDevelopment of effective nanomedicines to deal with tumor immunogenicity and immunosuppression is vital to improve the immunotherapy efficacy. Herein, we developed a programmed strategy not only to activate the tumoral immune microenvironment through immunogenic cell death (ICD) effect but also to promote the maturation of dendritic cells (DCs) in lymph nodes through two modules of core-shell tecto dendrimer (CSTD)-based nanomedicines. The CSTDs with amplified tumor enhanced permeability and retention eff...
Source: Cancer Control - May 18, 2023 Category: Cancer & Oncology Authors: Cong Song Mengsi Zhan Zhijun Ouyang Yuge Yao Yue Gao Mingwu Shen Xiangyang Shi Source Type: research

Inhibition of FGFR3 upregulates MHC ‐I and PD‐L1 via TLR3/NF‐kB pathway in muscle‐invasive bladder cancer
ConclusionTogether, our results suggest that FGFR3 might involve in immunosuppression by inhibition of NF-kB pathway in BC. Considering that TLR3 agonists are currently approved for clinical treatment as immunoadjuvants, our study might provide more insights for improving the efficacy of immunotherapy in MIBC.
Source: Cancer Medicine - June 7, 2023 Category: Cancer & Oncology Authors: WenBo Wu, Lei Chen, GaoZhen Jia, QiLin Tang, BangMin Han, ShuJie Xia, Qi Jiang, HaiTao Liu Tags: RESEARCH ARTICLE Source Type: research

Exploring the correlation of glycolysis-related chondroitin polymerizing factor ( < em > CHPF < /em > ) with clinical characteristics, immune infiltration, and cuproptosis in bladder cancer
Am J Cancer Res. 2023 Jun 15;13(6):2213-2233. eCollection 2023.ABSTRACTBladder cancer (BLCA) is a common malignant neoplasm of the urinary system. Glycolysis is an essential metabolic pathway regulated by various genes with implications for tumor progression and immune escape. Scoring the glycolysis for each sample in the TCGA-BLCA dataset was done using the ssGSEA algorithm for quantification. The results showed that the score in BLCA tissues was markedly greater than those in adjacent tissues. Additionally, the score was found to be correlated with metastasis and high pathological stage. Functional enrichment analyses of...
Source: Cell Research - July 10, 2023 Category: Cytology Authors: Quliang Zhong Kehua Jiang Facai Zhang Yuan Tian Jiang Gu Tao Li Xulong Chen Jianjun Yang Fa Sun Source Type: research

Lipid-Polymer Hybrid Nanoparticles with Both PD-L1 Knockdown and Mild Photothermal Effect for Tumor Photothermal Immunotherapy
In this study, dopamine-modified polyethylenimine (PEI) was prepared to fabricate an IR780 and siPD-L1 codelivery lipid-polymer hybrid nanoparticle (lip@PSD-siP) for the photothermal immunotherapy of CRC. The modification of dopamine can significantly reduce the cytotoxicity of PEI. lip@PSD-siP can be effectively taken up by CT26 cells and successfully escaped from lysosomes after entering the cells for 4 h. After CT26 cells were transfected with lip@PSD-siP, the PD-L1 positive cell rate decreased by 82.4%, and its PD-L1 knockdown effect was significantly stronger than the positive control Lipo3000-siP. In vivo studies sho...
Source: Cancer Control - August 22, 2023 Category: Cancer & Oncology Authors: Di Chuan Rangrang Fan Bo Chen Yangmei Ren Min Mu Haifeng Chen Bingwen Zou Haohao Dong Aiping Tong Gang Guo Source Type: research