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Nutrition: Vitamins
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Total 289 results found since Jan 2013.
Protective Effects of 1,25 Dihydroxyvitamin D < sub > 3 < /sub > against High-Glucose-Induced Damage in Human Umbilical Vein Endothelial Cells Involve Activation of Nrf2 Antioxidant Signaling
Conclusions: 1,25(OH)2D3 attenuates high-glucose-induced endothelial oxidative injury through upregulation of the Nrf2 antioxidant pathway in a VDR-dependent manner.J Vasc Res
Source: Journal of Vascular Research - May 4, 2021 Category: Research Source Type: research
Ischemia-Reperfusion Injury Reduces Kidney Folate Transporter Expression and Plasma Folate Levels
In conclusion, ischemia-reperfusion injury can downregulate Sp1 mediated-folate transporter expression in tubular cells, which may reduce folate reabsorption and lead to low folate status.
Source: Frontiers in Immunology - June 4, 2021 Category: Allergy & Immunology Source Type: research
TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts
This study assessed the effect of calcitriol on PRMT1-dependent fibroblast remodeling in human lung fibroblasts, and allergen-induced asthma in E3-rats. Fibroblasts were activated with thymic stromal lymphopoietin (TLSP); asthma was induced by ovalbumin inhalation in rats. The airway structure was assessed by immunohistology. Protein expression in fibroblasts and activation of the mitogen activated protein kinases were detected by Western-blotting. Transcription factor activation was determined by luciferase reporter assay. PRMT1 action was blocked by siRNA and PRMT-inhibition. Ovalbumin upregulated the expression of TSLP,...
Source: Biochimica et Biophysica Acta - June 20, 2021 Category: Biochemistry Authors: Ai Jin Xuemei Tang Weiqi Zhai Yuwen Li Qingzhu Sun Li Liu Xiaojun Yang Hui Ren Shemin Lu Source Type: research
Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease
Free Radic Biol Med. 2021 Jun 23:S0891-5849(21)00385-3. doi: 10.1016/j.freeradbiomed.2021.06.020. Online ahead of print.ABSTRACTVascular calcification is very commonly observed in patients with chronic kidney disease (CKD), but there is no efficient therapy available. Oxidative stress plays critical roles in the progression of vascular calcification. Celastrol (Cel), a natural constituent derived from Chinese herbals, exhibits anti-oxidative stress activity. Here, we investigated the effect of celastrol on vascular calcification using vascular smooth muscle cells (VSMCs), arterial rings and CKD rats. Alizarin red staining ...
Source: Free Radical Biology and Medicine - June 26, 2021 Category: Biology Authors: Xiulin Yang An Chen Qingchun Liang Qianqian Dong Mingwei Fu Xiaoyu Liu Siyi Wang Yining Li Yuanzhi Ye Zirong Lan Jing-Song Ou Lihe Lu Jianyun Yan Source Type: research
Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells
CONCLUSION: In this study we provide evidence that nicotine induces Nox5-mediated pro-calcific processes as novel mechanism of increased atherosclerotic calcification. We identified that activation of α7 and α3 nAChR by nicotine increases intracellular Ca2+ and initiates calcification of hVSMCs through increased Nox5 activity, leading to oxidative stress-mediated EV release. Identifying the role of Nox5-induced oxidative stress opens novel avenues for diagnosis and treatment of smoking-induced cardiovascular disease.PMID:34273166 | DOI:10.1093/cvr/cvab244
Source: Cell Research - July 17, 2021 Category: Cytology Authors: Ploingarm Petsophonsakul Mathias Burgmaier Brecht Willems Sylvia Heeneman Nadina Stadler Felix Gremse Sebastian Reith Kathrin Burgmaier Florian Kahles Nikolaus Marx Ehsan Natour Elham Bidar Michael Jacobs Barend Mees Chris Reutelingsperger Malgorzata Furm Source Type: research
Hypoxia-Inducible Factor-1 α (HIF-1α) Inhibition Impairs Retinoic Acid-Induced Differentiation in SH-SY5Y Neuroblastoma Cells, Leading to Reduced Neurite Length and Diminished Gene Expression Related to Cell Differentiation
Neurochem Res. 2021 Sep 23. doi: 10.1007/s11064-021-03454-3. Online ahead of print.ABSTRACTNeuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatment. Several studies indicate that hypoxia-a common feature of the tumoural environment-is a key player in cell differentiation and proliferation. Hypoxia leads to the accumulation of the hypoxia-inducible factor-1α (HIF-1α). This work aim...
Source: Neurochemical Research - September 24, 2021 Category: Neuroscience Authors: Pedro Ozorio Brum Guilherme Danielski Viola Carolina Saibro-Girardi Camila Tiefensee-Ribeiro Matheus Ozorio Brum Juciano Gasparotto Rachel Krolow Jos é Cláudio Fonseca Moreira Daniel Pens Gelain Source Type: research
Hypoxia-Inducible Factor-1alpha (HIF-1alpha) Inhibition Impairs Retinoic Acid-Induced Differentiation in SH-SY5Y Neuroblastoma Cells, Leading to Reduced Neurite Length and Diminished Gene Expression Related to Cell Differentiation
Neurochem Res. 2021 Sep 23. doi: 10.1007/s11064-021-03454-3. Online ahead of print.ABSTRACTNeuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatment. Several studies indicate that hypoxia-a common feature of the tumoural environment-is a key player in cell differentiation and proliferation. Hypoxia leads to the accumulation of the hypoxia-inducible factor-1α (HIF-1α). This work aim...
Source: Cell Research - September 24, 2021 Category: Cytology Authors: Pedro Ozorio Brum Guilherme Danielski Viola Carolina Saibro-Girardi Camila Tiefensee-Ribeiro Matheus Ozorio Brum Juciano Gasparotto Rachel Krolow Jos é Cláudio Fonseca Moreira Daniel Pens Gelain Source Type: research
Hypoxia-Inducible Factor-1 α (HIF-1α) Inhibition Impairs Retinoic Acid-Induced Differentiation in SH-SY5Y Neuroblastoma Cells, Leading to Reduced Neurite Length and Diminished Gene Expression Related to Cell Differentiation
Neurochem Res. 2021 Sep 23. doi: 10.1007/s11064-021-03454-3. Online ahead of print.ABSTRACTNeuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatment. Several studies indicate that hypoxia-a common feature of the tumoural environment-is a key player in cell differentiation and proliferation. Hypoxia leads to the accumulation of the hypoxia-inducible factor-1α (HIF-1α). This work aim...
Source: Neurochemical Research - September 24, 2021 Category: Neuroscience Authors: Pedro Ozorio Brum Guilherme Danielski Viola Carolina Saibro-Girardi Camila Tiefensee-Ribeiro Matheus Ozorio Brum Juciano Gasparotto Rachel Krolow Jos é Cláudio Fonseca Moreira Daniel Pens Gelain Source Type: research
Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake
Int J Biol Macromol. 2021 Oct 18:S0141-8130(21)02211-X. doi: 10.1016/j.ijbiomac.2021.10.058. Online ahead of print.ABSTRACTAscorbic acid (AA) uptake in neurons occurs via a Na+-dependent carrier-mediated process mediated by the sodium-dependent vitamin C transporter-2 (SVCT2). Relatively little information is available concerning the network of interacting proteins that support human (h)SVCT2 trafficking and cell surface expression in neuronal cells. Here we identified the synaptogenic adhesion protein, calsyntenin-3 (CLSTN3) as an hSVCT2 interacting protein from yeast two-hybrid (Y2H) screening of a human adult brain cDNA...
Source: International Journal of Biological Macromolecules - October 21, 2021 Category: Biochemistry Authors: Veedamali S Subramanian Trevor Teafatiller Janielle Vidal Gihan S Gunaratne Carlos J Rodriguez-Ortiz Masashi Kitazawa Jonathan S Marchant Source Type: research
CCAAT/Enhancer-Binding Protein Alpha Is a Novel Regulator of Vascular Smooth Muscle Cell Osteochondrogenic Transition and Vascular Calcification
ConclusionFindings in this study indicate that C/EBPα is a key regulator of the osteochondrogenic transdifferentiation of VSMCs and vascular calcification, which may represent a novel therapeutic target for vascular calcification.
Source: Frontiers in Physiology - February 28, 2022 Category: Physiology Source Type: research
