Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells

CONCLUSION: In this study we provide evidence that nicotine induces Nox5-mediated pro-calcific processes as novel mechanism of increased atherosclerotic calcification. We identified that activation of α7 and α3 nAChR by nicotine increases intracellular Ca2+ and initiates calcification of hVSMCs through increased Nox5 activity, leading to oxidative stress-mediated EV release. Identifying the role of Nox5-induced oxidative stress opens novel avenues for diagnosis and treatment of smoking-induced cardiovascular disease.PMID:34273166 | DOI:10.1093/cvr/cvab244

Source: Cell Research - July 17, 2021 Category: Cytology Authors: Ploingarm Petsophonsakul Mathias Burgmaier Brecht Willems Sylvia Heeneman Nadina Stadler Felix Gremse Sebastian Reith Kathrin Burgmaier Florian Kahles Nikolaus Marx Ehsan Natour Elham Bidar Michael Jacobs Barend Mees Chris Reutelingsperger Malgorzata Furm Source Type: research