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Microbiota of the Gut-Lymph Node Axis: Depletion of Mucosa-Associated Segmented Filamentous Bacteria and Enrichment of Methanobrevibacter by Colistin Sulfate and Linco-Spectin in Pigs
This study aimed to characterize shifts in microbial community structure across the intestinal mucosa-enteric lymph node axis in order to understand the effects of two commonly used antibiotics (Linco-Spectin and Colistin sulfate; oral application). We hypothesized that these antibiotics influence GI microbiota diversity and community structure and that, as a result, the ICLN-ileum axis is altered through permeability changes and changed translocation patterns. Medicated-feed antibiotics are still heavily used, not only in the E.U. but worldwide in case of infections. In addition to the taxonomic community profiling survey...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

Properties of Poly- γ-Glutamic Acid Producing-Bacillus Species Isolated From Ogi Liquor and Lemon-Ogi Liquor
Conclusion γPGA-producing Bacillus spp. were isolated during fermentation of OSL and LOSL at 0–12 h. These isolates exhibited antibacterial and ACE inhibitory activities at different concentrations. The individual antibacterial activities of γPGA were bacteriostatic while the combined use exhibited bactericidal characteristics. Although the ACE inhibitory activities were low, OSL and LOSL are promising sources for developing functional microorganisms with a beneficial impact on health. The importance lies in the benefits derived from the use of local resources. Author Contributions TA contributed to...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model
Conclusion: The genome-wide screen in the yeast deletion library allowed us to identify a large number of host genes required for AaCdtB cytotoxicity. Further investigation could lead to more insights into the mechanisms of CdtB intoxication. Introduction Bacterial pathogens often possess several virulence factors to facilitate colonization and survival in hosts. Cytolethal distending toxin (CDT) is a genotoxin produced by many Gram-negative pathogens, such as Escherichia coli, Aggregatibacter actinomycetemcomitans, Haemophilus ducreyi, Shigella dysenteriae, Helicobacter hepaticus, and Campylobacter species (Gargi ...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research

Microbial Diversity and Antimicrobial Resistance Profile in Microbiota From Soils of Conventional and Organic Farming Systems
According to this study it may be outlined that soil microbiota is a stable component as it were detected similar composition of microorganisms in soil both in organic as well as in conventional farming systems with similar soil structure and pH. The different amount of phosphorus in soils had no influence on bacterial variety at a genera level although more investigations would be useful to investigate changes among separate species. During evolution microorganisms adapted to survive in ecosystems independently of certain changes and probably serve as a buffer for ecological niches. It is unclear, however, what level of i...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research

Emerging strategies for the noninvasive diagnosis of nosocomial pneumonia.
Authors: Liapikou A, Cillóniz C, Torres A Abstract Introduction: Hospital-acquired pneumonia is a common and therapeutically challenging diagnosis that can lead to severe sepsis, critical illness, and respiratory failure. In this review, we focus on efforts to enhance microbiological diagnosis of hospital-acquired pneumonia, including ventilator-associated pneumonia. Areas covered: A systematic literature review was conducted by searching Medline from inception to December 2018, including hand-searching of the reference lists for additional studies. The search strategy comprised the following common search terms: ...
Source: Expert Review of Anti-Infective Therapy - June 28, 2019 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

Clinical Controversy in Transplantation: Tacrolimus Versus Cyclosporine in Statin Drug Interactions.
Conclusions: Clinicians need to be aware that tacrolimus and cyclosporine are not the same with regard to causing drug interactions with statins. Tacrolimus can be used with statins without the need for dose adjustments because of lack of an interaction. PMID: 31441337 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - August 22, 2019 Category: Drugs & Pharmacology Authors: Migliozzi DR, Asal NJ Tags: Ann Pharmacother Source Type: research

Hollow structural metal-organic frameworks exhibit high drug loading capacity, targeted delivery and magnetic resonance/optical multimodal imaging
Dalton Trans., 2019, Accepted Manuscript DOI: 10.1039/C9DT03287H, PaperXuechuan Gao, Ruixue Cui, Lijun Song, Zhiliang Liu Metal-organic frameworks (MOFs) are attractive in designing drug delivery systems for the treatment of cancer because of their unique porous properties. However, the search for mutlifunctional MOFs combined with high... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - October 28, 2019 Category: Chemistry Authors: Xuechuan Gao Source Type: research

(TMT-TTF)Pb2.6/3 □0.4/3I23: a TTF intercalated two-dimensional hybrid lead iodide: crystal structure and properties
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ04316K, PaperWen-Yu Yin, Yi-Gang Weng, Miao Jiang, Shuai-Kang Yu, Qin-Yu Zhu, Jie Dai The poor conductive organic layers in two-dimensional (2D) perovskites create quantum wells that hinder the carrier separation and transformation. Therefore, the search for new 2D hybrid lead-halide materials with conductive... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - December 17, 2019 Category: Chemistry Authors: Wen-Yu Yin Source Type: research

Consumer perceptions, preferences, and behavior regarding pasture-raised livestock products: A review
This article is the first to review scientific consumer studies on perceptions, preferences, behavior regarding and willingness to pay for pasture-raised products. Further research, especially research based on real market data, is recommended to explore the effect of specific environmental attributes, social and personal norms, informational content, and product types on consumer preferences and willingness to pay for pasture-raised products.
Source: Food Quality and Preference - January 11, 2020 Category: Food Science Source Type: research

A review of Penthorum chinense Pursh for hepatoprotection: Traditional use, phytochemistry, pharmacology, toxicology and clinical trials
ConclusionP. chinense seems to be safe and shows relevant liver protecting effects. Therefore, it might be a promising candidate for developing as new hepatoprotective agents. However, a lack of understanding of the active compounds and mechanisms of action needs further attention.Graphical abstract
Source: Journal of Ethnopharmacology - January 12, 2020 Category: Drugs & Pharmacology Source Type: research

Rational Design of a Novel Catalyst Cu ‐SAPO‐42 for NH3‐SCR Reaction
SAPO ‐42 (LTA topology) is targeted synthesized with a series of commercialized amines in the absence of fluoride byRSS method. Furthermore, Cu ‐SAPO‐42 exhibits excellent activity and thermal durability in NH3‐SCR even after hydrothermal aging at 800 °C for 16 h, especially at the high‐temperature range. AbstractCu ‐exchanged LTA‐type aluminosilicate catalyst has been considered as an efficient catalyst for the selective catalytic reduction of NOx with ammonia (NH3‐SCR). However, expensive organic structure‐directing agents (OSDAs) and the corrosive fluoride medium are inevitably used to synthesize LTA...
Source: Small - July 18, 2020 Category: Nanotechnology Authors: Nana Yan, Chao Ma, Yi Cao, Xiaona Liu, Lei Cao, Peng Guo, Peng Tian, Zhongmin Liu Tags: Full Paper Source Type: research

Microbial Keratinase: Next Generation Green Catalyst and Prospective Applications
The search for novel renewable products over synthetics hallmarked this decade and those of the recent past. Most economies that are prospecting on biodiversity for improved bio-economy favor renewable resources over synthetics for the potential opportunity they hold. However, this field is still nascent as the bulk of the available resources are non-renewable based. Microbial metabolites, emphasis on secondary metabolites, are viable alternatives; nonetheless, vast microbial resources remain under-exploited; thus, the need for a continuum in the search for new products or bio-modifying existing products for novel function...
Source: Frontiers in Microbiology - December 18, 2020 Category: Microbiology Source Type: research

Synthesis and evaluation of sensitive coumarin-based fluorogenic substrates for discovery of α-N-acetyl galactosaminidases through droplet-based screening
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02484H, CommunicationHongming Chen, Seyed Amirhossein Nasseri, Peter Rahfeld, Jacob F. Wardman, Maurits Kohsiek, Stephen G. Withers As part of a search for a substrate for droplet-based microfluidic screening assay of -N-acetylgalactosaminidases, spectral and physical characteristics of a series of coumarin derivatives were measured. From among these... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - December 19, 2020 Category: Molecular Biology Authors: Hongming Chen Source Type: research

Advances in Deep Eutectic Solvents and Water: Applications in Metal- and Biocatalyzed Processes, in the Synthesis of APIs, and other Biologically Active Compounds
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D0OB02491K, Review ArticleLuciana Cicco, Giuseppe Dilauro, Filippo M. Perna, Paola Vitale, Vito Capriati Owing to a growing awareness towards environmental impact, the search for “greener”, safer, and cost-effective solvents able to replace petroleum-derived solvents has never been greater today. In this context, the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - January 13, 2021 Category: Molecular Biology Authors: Luciana Cicco Source Type: research