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Total 106 results found since Jan 2013.

Evaluation of Clinical Outcomes in Hospitalized Patients With Exertional Rhabdomyolysis.
Conclusion: Hospitalized patients with ER without a history of renal impairment tend to have relatively low risks of complications and readmission. PMID: 31233108 [PubMed - in process]
Source: Journal of the American Osteopathic Association - June 25, 2019 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

How Common is Restless Legs Syndrome in Children?
Discussion Restless legs syndrome (RLS) is also known as Willis-Ekbom disease. RLS is a clinical diagnosis with criteria being: 1. An urge to move the legs usually accompanied by uncomfortable and unpleasant sensations in the lower extremities (Note: sometimes other body parts can be affected) 2. The urge to move begins or worsens when sitting or lying down 3. The urge to move is partially or totally relieved by movement (Note: relief by activity may not be noticable if severely affected but must have been previously present) 4. The urge to move the legs and any accompanying unpleasant sensations during rest or in activ...
Source: PediatricEducation.org - June 10, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Muscle weakness: Understanding the principles of myopathy and neuropathy in the critically ill patient and the management options
Myo-neuropathy of the critically ill patient is a difficult nosological entity to understand and manage. It appears soon after injury, and it is estimated that 20-30% of patients admitted to Intensive Care Units will develop it in some degree. Although muscular and nervous involvement are related, the former has a better prognosis. Myo-neuropathy associates to more morbidity, longer stay in Intensive Care Unit and in hospital, and also to higher costs and mortality. It is considered part of the main determinants of the new entities: the Chronic Critical Patient and the Post Intensive Care Syndrome.
Source: Clinical Nutrition - June 7, 2019 Category: Nutrition Authors: Miguel Ángel García-Martínez, Juan Carlos Montejo González, Abelardo García-de-Lorenzo y Mateos, Susana Teijeira Bautista Tags: Review Source Type: research

Spontaneous Restoration of Nutrition Autonomy in a Case of Intestinal Failure Secondary to a Gastrointestinal Neuromuscular Disease.
Abstract Polyglucosan inclusion body myopathy (PIBM) is a recently described gastrointestinal neuromuscular disease. Given its rarity, very little is known of its natural history and prognosis. In this case report, we present the first case of PIBM and resultant intestinal failure in which, following 7 years of home parenteral nutrition, gastrointestinal symptoms subsided and nutrition autonomy was restored. PMID: 31074888 [PubMed - as supplied by publisher]
Source: Nutrition in Clinical Practice - May 9, 2019 Category: Nutrition Authors: McCulloch A, Malhi H, Parkinson S, Martin JE, Cooper SC Tags: Nutr Clin Pract Source Type: research

Hypothyroidism as a Predictor of Surgical Outcomes in the Elderly
Conclusions It is recommended to post-pone elective surgery in elderly patients with hypothyroidism until an euthyroid state is achieved. If patients need urgent or emergent surgery, it is recommended to proceed with surgery only if they have mild or moderate hypothyroidism. Replacement therapy should be started preoperatively and there should be growing attention to the possible occurrence of minor post-operative complications in hypothyroid patients. As suggested by the American Thyroid Association (ATA), the treatment in elderly patients should be initiated at low doses with slow titration based on serum TSH evaluation...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

DNA polymerase- γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: a potentially protective role for citrus fruit-derived naringenin?
DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: a potentially protective role for citrus fruit-derived naringenin? Eur J Pharmacol. 2019 Mar 12;: Authors: Lutu MR, Nzuza S, Mofo Mato PE, Govender K, Gumede LM, Kumalo SI, Mlambo NN, Hurchund R, Oroma Owira PM Abstract Nucleoside reverse transcriptase inhibitors (NRTIs) form the backbone in combination antiretroviral therapy (cARVs). They halt chain elongation of the viral cDNA by acting as false substrates in counterfeit incorporation mechanism to viral RNA-dependent DNA polymerase. In the proc...
Source: European Journal of Pharmacology - March 11, 2019 Category: Drugs & Pharmacology Authors: Lutu MR, Nzuza S, Mofo Mato PE, Govender K, Gumede LM, Kumalo SI, Mlambo NN, Hurchund R, Oroma Owira PM Tags: Eur J Pharmacol Source Type: research

Oral Pyridostigmine-responsive Visceral Myopathy With ACTG2 Mutations: A Case Series
No abstract available
Source: Journal of Pediatric Gastroenterology and Nutrition - December 29, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes and treatment strategies.
Authors: Hamed SA Abstract INTRODUCTION: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Areas covered: This review summarized central and peripheral nervous system complications of uremic syndrome of CKD and their pathogenic mechanisms. They include cognitive deterioration, encephalopathy, seizures, asterixis, myoclonus, restless leg syndrome, central pontine mye...
Source: Expert Review of Clinical Pharmacology - December 7, 2018 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research

Effect of Transcutaneous Electrical Neuromuscular Stimulation on Myopathy in Intensive Care Patients.
CONCLUSION: TENMS had no significant impact on myopathy in the critically ill patients in this study. PMID: 30385541 [PubMed - in process]
Source: American Journal of Critical Care - November 1, 2018 Category: Nursing Authors: Koutsioumpa E, Makris D, Theochari A, Bagka D, Stathakis S, Manoulakas E, Sgantzos M, Zakynthinos E Tags: Am J Crit Care Source Type: research

Alpha-lipoic acid preserves skeletal muscle mass in type 2 diabetic OLETF rats
Increased oxidative stress and impaired antioxidant defense are important mechanisms in the pathogenesis of diabetic myopathy. Alpha-lipoic acid (ALA) has been indicated as a weight-loss treatment in rodents a...
Source: Nutrition and Metabolism - September 29, 2018 Category: Nutrition Authors: Oak-Kee Hong, Jang-Won Son, Hyuk-Sang Kwon, Seong-Su Lee, Sung-Rae Kim and Soon Jib Yoo Tags: Research Source Type: research

Dietary Supplements and Cardiovascular Diseases
The market of nutritional supplements is expected to expand over 6%/year through 2018 due to growing interest in personal health, aging population, and promising personalized care products. The most used dietary supplements are fish oil, multivitamins, Vitamin D, and coenzyme Q10 (CoQ10) in this order, while probiotics is the fastest growing supplement. In the U.S., over 68% of the population use dietary supplements regularly. On the other hand, in the developed countries, cardiovascular diseases (CVDs) are the main cause of death and morbidity from the 1900s. The effects of most dietary supplements on cardiovascular risk ...
Source: International Journal of Preventive Medicine - September 22, 2018 Category: International Medicine & Public Health Source Type: research

Mechanisms Underlying Muscle Protein Imbalance Induced by Alcohol.
Abstract Both acute intoxication and longer-term cumulative ingestion of alcohol negatively impact the metabolic phenotype of both skeletal and cardiac muscle, independent of overt protein calorie malnutrition, resulting in loss of skeletal muscle strength and cardiac contractility. In large part, these alcohol-induced changes are mediated by a decrease in protein synthesis that in turn is governed by impaired activity of a protein kinase, the mechanistic target of rapamycin (mTOR). Herein, we summarize recent advances in understanding mTOR signal transduction, similarities and differences between the effects of a...
Source: Annual Review of Nutrition - August 21, 2018 Category: Nutrition Authors: Kimball SR, Lang CH Tags: Annu Rev Nutr Source Type: research

Adverse Events to Food Supplements Containing Red Yeast Rice: Comparative Analysis of FAERS and CAERS Reporting Systems
ConclusionsNotwithstanding recognized limitations, these findings strengthen the importance of exploring multiple databases in safety assessment of RYR products, which should be monitored by clinicians for muscular and hepatic safety, and call for urgent review by policymakers to harmonize their regulatory status.
Source: Drug Safety - March 26, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of dietary sodium selenite and organic selenium sources on immune and inflammatory responses and selenium deposition in growing pigs
This study was conducted to compare effects of different dietary Se sources (sodium selenite [NaSe], Se-enriched yeast [Se yeast] or L-selenomethionine [SeMet]) and one Se-deficient control diet on the expression of selected genes, hematological and clinical biochemical parameters, and muscle morphology in two parallel trials with finisher pigs. Se concentrations in blood plasma and tissues were also monitored. From the pigs in one of the parallel groups, muscle samples obtained from Musculus longissimus dorsi (LD) before and during the trial were examined. The pigs in the other parallel group were challenged once with lip...
Source: Journal of Trace Elements in Medicine and Biology - March 9, 2018 Category: Biochemistry Source Type: research

Diagnostic Criteria of Pediatric Intestinal Myopathies
The authors aim to identify criteria for the diagnosis of intestinal visceral myopathy (IVM); results were compared with ultrastructural studies. Six IVM patients and 7 pediatric control cases (without gastrointestinal diseases) were studied. One case was a typical megacystis-microcolon-intestinal hypoperistalsis syndrome. The diagnostic path included: rectal suction biopsy, one-trocar transumbilical laparoscopic intestinal full-thickness biopsy technique. Pathological analysis included anti-alpha smooth muscle actin staining, and US study of intestinal biopsies. IVM histological examination demonstrated thinning of longit...
Source: Journal of Pediatric Gastroenterology and Nutrition - February 24, 2018 Category: Gastroenterology Tags: Short Communications: Gastroenterology Source Type: research