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Total 25 results found since Jan 2013.
From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives
In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research
WITHDRAWN: Systemic treatments for metastatic cutaneous melanoma.
CONCLUSIONS: There is no evidence from randomised controlled clinical trials to show superiority of systemic therapy over best supportive care / placebo in the treatment of malignant cutaneous melanoma.Given that patients with metastatic melanoma frequently receive systemic therapy, it is our pragmatic view that a future systematic review could compare any systemic treatment, or combination of treatments, to single agent dacarbazine.
PMID: 29411867 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 7, 2018 Category: General Medicine Authors: Crosby T, Fish R, Coles B, Mason M Tags: Cochrane Database Syst Rev Source Type: research
Techniques for Studying Decoding of Single Cell Dynamics
Stevan Jeknić1,2†, Takamasa Kudo2,3† and Markus W. Covert1,2,3*
1Department of Bioengineering, Stanford University, Stanford, CA, United States
2Allen Discovery Center for Systems Modeling of Infection, Stanford, CA, United States
3Department of Chemical and Systems Biology, Stanford University, Stanford, CA, United States
Cells must be able to interpret signals they encounter and reliably generate an appropriate response. It has long been known that the dynamics of transcription factor and kinase activation can play a crucial role in selecting an individual cell's response. The ...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research
Antimicrobial Resistance Calls for Brainpower of a Space Agency and Campaigning Zeal of an NGO
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Source: IPS Inter Press Service - Health - November 17, 2021 Category: International Medicine & Public Health Authors: External Source Tags: Global Headlines Health Source Type: news
False positivity in break apart fluorescence in-situ hybridization due to polyploidy
CONCLUSIONS: In case of polyploidy there is an increased likelihood of false positivity when using break apart FISH probes. Therefore, we state that prescribing one single cut-off in FISH is inappropriate. In polyploidy, the currently proposed cut-off should only be used with caution and the result should be confirmed by an additional technique.PMID:37197629 | PMC:PMC10183404 | DOI:10.21037/tlcr-22-516
Source: Cell Research - May 17, 2023 Category: Cytology Authors: Anna Lena van Gulik Ellen Sluydts Liesbet Vervoort Mark Kockx Pim Kortman Bauke Ylstra Stephen P Finn Lukas Bubendorf Idris Bahce Daoud Sie Teodora Radonic Birgit Lissenberg-Witte Erik Thunnissen Source Type: research
Identification of novel αβ-tubulin modulators with antiproliferative activity directed to cancer therapy using ligand and structure-based virtual screening
Int J Biol Macromol. 2020 Dec 15;165(Pt B):3040-3050. doi: 10.1016/j.ijbiomac.2020.10.136. Epub 2020 Oct 22.ABSTRACTAmong several strategies related to cancer therapy targeting the modulation of αβ-tubulin has shown encouraging findings, more specifically when this is achieved by inhibitors located at the colchicine binding site. In this work, we aim to fish new αβ-tubulin modulators through a diverse and rational VS study, and thus, exhibiting the development of two VS pipelines. This allowed us to identify two compounds 5 and 9 that showed IC50 values of 19.69 and 21.97 μM, respectively, towards possible modulation ...
Source: International Journal of Biological Macromolecules - March 19, 2021 Category: Biochemistry Authors: Leonardo Bruno Federico Guilherme Martins Silva Amanda de Fraga Dias Fabr ício Figueiró Ana Maria Oliveira Battastini Cleydson Breno Rodrigues Dos Santos Luciano T Costa Joaqu ín Maria Carmpos Rosa Carlos Henrique Tomich de Paula da Silva Source Type: research
Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?
Clin Sci (Lond). 2021 Jun 25;135(12):1487-1503. doi: 10.1042/CS20210059.ABSTRACTSignificant improvements in cancer survival have brought to light unintended long-term adverse cardiovascular effects associated with cancer treatment. Although capable of manifesting a broad range of cardiovascular complications, cancer therapy-related cardiac dysfunction (CTRCD) remains particularly common among the mainstay anthracycline-based and human epidermal growth factor receptor-targeted therapies. Unfortunately, the early asymptomatic stages of CTRCD are difficult to detect by cardiac imaging alone, and the initiating mechanisms rema...
Source: Clinical Breast Cancer - June 17, 2021 Category: Cancer & Oncology Authors: Crizza Ching Dakota Gustafson Paaladinesh Thavendiranathan Jason E Fish Source Type: research
In Silico Protein-Protein Interaction of Pterois volitans Venom with Cancer Inducers of Helicobacter pylori
This study focuses on an in silico approach using Z-dock to analyze the bioactive prospective of the venom proteins of P. volitans against the essential virulence proteins of H. pylori responsible for inducing cancer. Our in silico docking study using a computational model of the venom proteins and H. pylori proteins has displayed the possible interactions between these proteins. The results revealed that P. volitans hyaluronidase and PV toxin's venom proteins effectively interact with H. pylori proteins Cag A, Cag L, GGT, Cag D, and urease that may be promising proteins in cancer therapy.PMID:34843077 | DOI:10.1007/s12010-021-03763-x
Source: Applied Biochemistry and Biotechnology - November 29, 2021 Category: Biochemistry Authors: Guru Nivetha Ravi Irfan Navabshan Sneha Unnikrishnan Karthikeyan Ramalingam Source Type: research
Comprehensive expression analysis for the core cell cycle regulators in the chicken embryo reveals novel tissue-specific synexpression groups and similarities and differences with expression in mouse, frog and zebrafish
This study for the first time undertook a comprehensive expression analysis for the core cell cycle regulators in the chicken, focusing in on early neurula and pharyngula stages of development, with the latter representing the vertebrate phylotypic stage. We also compared our data with published data for the mouse, Xenopus and zebrafish, the other established vertebrate models. Our work shows that, while many genes are expressed widely, some are upregulated or specifically expressed in defined tissues of the chicken embryo, forming novel synexpression groups with markers for distinct developmental pathways. Moreover, we fo...
Source: Journal of Anatomy - February 11, 2022 Category: Anatomy Authors: Marta Alaiz Noya Federica Berti Susanne Dietrich Source Type: research
