• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research

Lactobacillus plantarum KLDS1.0318 Ameliorates Impaired Intestinal Immunity and Metabolic Disorders in Cyclophosphamide-Treated Mice
Conclusion In conclusion, the present study showed that the oral administration of L. plantarum KLDS1.0318 normalized the parameters altered by CTX-induced toxicities, strengthening intestinal health by regulating the Th1/Th2 balance, ameliorating the intestinal morphology and improving profiles of intestinal microbiota and metabolism. Therefore, our findings suggested that the administration of L. plantarum KLDS1.0318 could be of significant advantage in reducing intestinal immunity impairment caused by cyclophosphamide. Ethics Statement This study was carried out according to the Animal Care Review Committee, Northeas...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

Molecular Characterization of Fructose-1,6-bisphosphate Aldolase From Trichinella spiralis and Its Potential in Inducing Immune Protection
In conclusion, our study indicated that Ts-FBPA was ubiquitously expressed at each developmental stage of T. spiralis and the protein was located at cuticles of the parasite and embryos, suggesting that the Ts-FBPA plays an important role in invasion and survival. Further functional experiments are required to elucidate the physiological and biological role of FBPA in parasite metabolism itself and Trichinella-host interaction. In addition, our study also indicated that mice immunized with rTs-FBPA had partial protective immunity against T. spiralis infection, however, we have yet to perform a clear picture of how immunity...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research

Molecules, Vol. 23, Pages 1451: Protein Carriers for Glycoconjugate Vaccines: History, Selection Criteria, Characterization and New Trends
ntino Currently licensed glycoconjugate vaccines are composed of a carbohydrate moiety covalently linked to a protein carrier. Polysaccharides are T-cell independent antigens able to directly stimulate B cells to produce antibodies. Disease burden caused by polysaccharide-encapsulated bacteria is highest in the first year of life, where plain polysaccharides are not generally immunogenic, limiting their use as vaccines. This limitation has been overcome by covalent coupling carbohydrate antigens to proteins that provide T cell epitopes. In addition to the protein carriers currently used in licensed glycoconjugate vacci...
Source: Molecules - June 15, 2018 Category: Chemistry Authors: Francesca Micoli Roberto Adamo Paolo Costantino Tags: Review Source Type: research

Role of Multivalency and Antigenic Threshold in Generating Protective Antibody Responses
Mark K. Slifka1* and Ian J. Amanna2 1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, United States2Najít Technologies, Inc., Beaverton, OR, United States Vaccines play a vital role in protecting our communities against infectious disease. Unfortunately, some vaccines provide only partial protection or in some cases vaccine-mediated immunity may wane rapidly, resulting in either increased susceptibility to that disease or a requirement for more booster vaccinations in order to maintain immunity above a protective level. The durabilit...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review
Conclusions and Suggestion for Direction of Further Studies A positive relationship between dietary Trp and brain 5-HT activity seems to be present across the vertebrate linage. However, there appear to be differences between teleost fishes and mammals when it comes to plasma Trp transport since teleost albumin lacks the indole binding site (29, 30). This makes Trp influx to the brain less sensitive to carbohydrates in fish compared to mammals. On the other hand, behavioral and neuroendocrine effects of elevated dietary Trp are similar in all vertebrates. Studies in mammals and teleost fishes show that these effects, incl...
Source: Frontiers in Endocrinology - April 7, 2019 Category: Endocrinology Source Type: research

Pages: 1  2