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Specialty: Drugs & Pharmacology
Nutrition: Calcium

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Total 67 results found since Jan 2013.

Investigation of morin-induced insulin secretion in cultured pancreatic cells.
This article is protected by copyright. All rights reserved. PMID: 28699234 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - July 12, 2017 Category: Drugs & Pharmacology Authors: Lin MH, Hsu CC, Lin J, Cheng JT, Wu MC Tags: Clin Exp Pharmacol Physiol Source Type: research

Recent Advances in the Development of T ‐type Calcium Channel Blockers for Pain Intervention
Abstract Cav3.2 T‐type calcium channels are important regulators of pain signals in afferent pain pathway, and their activities are dysregulated during various chronic pain states. Therefore it stands to reason that inhibiting T‐type calcium channels in dorsal root ganglion neurons and in the spinal dorsal horn can be targeted for pain relief. This is supported by early pharmacological studies with T‐type channel blockers such as ethosuximide, and by analgesic effects of siRNA depletion of Cav3.2 channels. In the past five years, considerable effort has been applied towards identifying novel classes of T‐type calci...
Source: British Journal of Pharmacology - June 13, 2017 Category: Drugs & Pharmacology Authors: Terrance P Snutch, Gerald W Zamponi Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

TRPV4 functions in flow shear stress induced early osteogenic differentiation of human bone marrow mesenchymal stem cells.
In this study, using FSS and calcium imaging, we demonstrated that FSS activated early osteogenic differentiation, as shown by the early osteogenic differentiation marker osterix (Osx) and alkaline phosphatase (ALP) staining. Increases in intracellular Ca(2+) and in the percentage of responding cells were induced by FSS. However, the late osteogenic differentiation marker Ocn and in vitro mineralization were unchanged after FSS stimulation. TRPV4 channels mediated the FSS-induced Ca(2+) influx and osteogenic differentiation of MSCs, which were inhibited by a selective TRPV4 blocker HC-067047 and specific Trpv4 siRNA. Ca(2+...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 11, 2017 Category: Drugs & Pharmacology Authors: Hu K, Sun H, Gui B, Sui C Tags: Biomed Pharmacother Source Type: research

Glucocorticoid-induced leucine zipper may play an important role in icariin by suppressing osteogenesis inhibition induced by glucocorticoids in osteoblasts
Conclusions These results indicate that the GILZ-mediated osteogenic signal pathway is involved in the osteogenic effect induced by icariin.
Source: Biomedicine and Pharmacotherapy - March 29, 2017 Category: Drugs & Pharmacology Source Type: research

Glucocorticoid-induced leucine zipper may play an important role in icariin by suppressing osteogenesis inhibition induced by glucocorticoids in osteoblasts.
CONCLUSIONS: These results indicate that the GILZ-mediated osteogenic signal pathway is involved in the osteogenic effect induced by icariin. PMID: 28363169 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2017 Category: Drugs & Pharmacology Authors: Lin Z, Jiang ZL, Chen LH, Sun Y, Chen SZ, Zhou P, Xia AX, Jin H, Zhu YW, Chen DY Tags: Biomed Pharmacother Source Type: research

TLR4/NF- κB/Ceramide signaling contributes to Ox-LDL-induced calcification of human vascular smooth muscle cells.
In conclusion, these findings suggest that TLR4 regulates VSMC calcification induced by Ox-LDL through activation of NK-κB, highlighting the critical role of TLR4/NK-κB signaling in vascular calcification. PMID: 27876618 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - November 18, 2016 Category: Drugs & Pharmacology Authors: Song Y, Hou M, Li Z, Luo C, Ou JS, Yu H, Yan J, Lu L Tags: Eur J Pharmacol Source Type: research

BAFF upregulates CD28/B7 and CD40/CD154 expression and promotes mouse T and B cell interaction in vitro via BAFF receptor.
CONCLUSION: BAFF upregulates CD28/B7 and CD40/CD154 expression, and promotes the interactions between T and B cells in a BAFF-R-dependent manner. PMID: 27180986 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 15, 2016 Category: Drugs & Pharmacology Authors: Zhang F, Song SS, Shu JL, Li Y, Wu YJ, Wang QT, Chen JY, Chang Y, Wu HX, Zhang LL, Wei W Tags: Acta Pharmacol Sin Source Type: research

Tenascin C affects mineralization of SaOS2 osteoblast-like cells through matrix vesicles.
In conclusion, in this study, we extended the role of TNC during osteogenesis previous progresses, and that supported TNC as an important functional MVs component in modulating osteoblast mineralization. PMID: 26961327 [PubMed - as supplied by publisher]
Source: Drug Discoveries and Therapeutics - March 11, 2016 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

Ophiopogonin D maintains Ca(2+) homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress.
CONCLUSION: OPD is a novel CYP2J3 inducer that may offer a therapeutic benefit in treatment of cardiovascular diseases related to disturbance of Ca(2+) homeostasis and ER stress. PMID: 26838069 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - February 1, 2016 Category: Drugs & Pharmacology Authors: You WT, Zhou T, Ma ZC, Liang QD, Xiao CR, Tang XL, Tan HL, Zhang BL, Wang YG, Gao Y Tags: Acta Pharmacol Sin Source Type: research

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in Human epithelial cells.
In conclusion, we show that TRPC6 channel is pivotal for the activation of CaCC by guanabenz through a α2-adrenergic-independent pathway in human airway epithelial cells. We suggest propose a functional coupling between TRPC6 and CaCC and guanabenz as a potential TRPC6 activator for exploring TRPC6 and CaCC channel functions and corresponding channelopathies. PMID: 26265544 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - August 8, 2015 Category: Drugs & Pharmacology Authors: Bertrand J, Dannhoffer L, Antigny F, Vachel L, Jayle C, Vandebrouck C, Becq F, Norez C Tags: Eur J Pharmacol Source Type: research

miR-135a suppresses calcification in senescent VSMCs by regulating KLF4/STAT3 pathway.
Abstract Cellular function phenotype is regulated by various microRNAs (miRs), including miR-135a. However, how miR-135a is involved in the calcification in senescent vascular smooth muscle cells (VSMCs) is not clear yet. In the present study, we first identified the significantly altered miRNAs in VSMCs, then performed consecutive passage culture of VSMCs and analyzed the expression of miR-135a and calcification genes in the senescent phase. Next, the effects of the miR-135a inhibition on calcification and calcification genes were analyzed. The luciferase assay was used to validate the target protein of miR-135a....
Source: Current Vascular Pharmacology - July 22, 2015 Category: Drugs & Pharmacology Authors: Lin L, He Y, Xi BL, Zheng HC, Chen Q, Li J, Hu Y, Ye MH, Chen P, Qu Y Tags: Curr Vasc Pharmacol Source Type: research

Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons.
Abstract The activation of α7 nAChRs has been shown to improve hippocampal-dependent learning and memory. However, the molecular mechanism of α7 nAChRs' action remains elusive. We previously reported that activation of α7 nAChRs induced a prolonged enhancement of glutamatergic synaptic transmission in a PKA-dependent manner. Here, we investigated any connection between the activation of the α7 nAChR and cAMP signaling in hippocampal neurons. To address this question, we employed a FRET-based biosensor to measure the intracellular cAMP levels directly via live cell imaging. We found that application of the α7 ...
Source: Neuropharmacology - April 29, 2015 Category: Drugs & Pharmacology Authors: Cheng Q, Yakel JL Tags: Neuropharmacology Source Type: research

Reactive oxygen species induce MMP12‐dependent degradation of collagen 5 and fibronectin to promote the motility of human umbilical cord‐derived mesenchymal stem cells
Conclusions and ImplicationsH2O2 stimulated UCB‐MSCs motility by increasing MMP12‐dependent degradation of COL‐5 and FN through the activation of NF‐κB and glycogen synthase kinase‐3β/β‐catenin, which is critical for providing a suitable microenvironment for MSCs transplantation and re‐epithelialization of skin wounds in mice.
Source: British Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Seung Pil Yun, Sei‐Jung Lee, Sang Yub Oh, Young Hyun Jung, Jung Min Ryu, Han Na Suh, Mi Ok Kim, Keon Bong Oh, Ho Jae Han Tags: RESEARCH PAPER Source Type: research

Probing Biased/Partial Agonism at the G Protein-Coupled A2B Adenosine Receptoř
Abstract G protein-coupled A2B adenosine receptor (AR) regulates numerous important physiological functions, but its activation by diverse A2BAR agonists is poorly profiled. We probed potential partial and/or biased agonism in cell lines expressing variable levels of endogenous or recombinant A2BAR. In cAMP accumulation assays, both 5'-substituted NECA and C2-substituted MRS3997 are full agonists. However, only 5'-substituted adenosine analogs are full agonists in calcium mobilization, ERK1/2 phosphorylation and β-arrestin translocation. A2BAR overexpression in HEK293 cells markedly increased the agonist potency ...
Source: Biochemical Pharmacology - May 19, 2014 Category: Drugs & Pharmacology Authors: Gao ZG, Balasubramanian R, Kiselev E, Wei Q, Jacobson KA Tags: Biochem Pharmacol Source Type: research

Reactive oxygen species induce matrix metalloproteinase‐12‐dependent degradation of collagen 5 and fibronectin to promote the motility of human umbilical cord derived mesenchymal stem cells
Conclusions and ImplicationsH2O2 stimulated UCB‐MSCs motility by increasing MMP‐12‐dependent degradation of COL‐5 and FN through the activation of NF‐κB and GSK‐3β/β‐catenin, which is critical for providing a suitable microenvironment for MSC transplantation and re‐epithelialization of mouse skin wounds.
Source: British Journal of Pharmacology - March 13, 2014 Category: Drugs & Pharmacology Authors: Seung Pil Yun, Sei‐Jung Lee, Sang Yub Oh, Young Hyun Jung, Jung Min Ryu, Han Na Suh, Mi Ok Kim, Keon Bong Oh, Ho Jae Han Tags: Research Paper Source Type: research