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British eggs: Back on the menu for all
This article updates the latest guidance and research on the suitability of eggs as a good source of nutrition for particular population groups. This follows the publication of two important UK government reports: revised advice for vulnerable groups from the Food Standards Agency and a draft report about infant feeding from the Scientific Advisory Committee on Nutrition (SACN), as well as a recent review on egg consumption and cardiovascular disease risk in people with type 2 diabetes. The Food Standards Agency now advises that raw or lightly cooked British eggs are safe to eat for vulnerable groups, such as pregnant wome...
Source: Nutrition Bulletin - February 13, 2018 Category: Nutrition Authors: J. Gray Tags: News and Views Source Type: research
Canada says working with FDA to address EpiPen shortage
TORONTO (Reuters) - Canada's government health agency said on Tuesday it is working with the U.S. Food and Drug Administration to address a shortage of Mylan N.V.'s EpiPen emergency allergy antidote that has hit several countries outside of the United States, where it is manufactured.
Source: Reuters: Health - April 17, 2018 Category: Consumer Health News Tags: healthNews Source Type: news
Canada Says Working With U.S. FDA to Address EpiPen Shortage Canada Says Working With U.S. FDA to Address EpiPen Shortage
Canada ' s government health agency said on Tuesday it is working with the U.S. Food and Drug Administration to address a shortage of Mylan N.V. ' s EpiPen emergency allergy antidote that has hit several countries outside of the United States, where it is manufactured.Reuters Health Information
Source: Medscape Medical News Headlines - April 19, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news
Lab-confirmed prenatal exposure to Zika is linked to cardiac defects in infants
In this study, researchers performed echocardiograms in infants with laboratory confirmation of in utero exposure to Zika to investigate a potential link between prenatal Zika exposure and congenital heart defects.METHODThe researchers performed cardiac echocardiograms in infants born in Rio de Janeiro, Brazil, from November 2015 to January 2017. All infants were infected with the Zika virus during their mothers ’ pregnancy, as confirmed by laboratory tests.IMPACTWomen infected by Zika during pregnancy were 10 times more likely than the general population to give birth to infants with major cardiac defects. The researche...
Source: UCLA Newsroom: Health Sciences - May 16, 2018 Category: Universities & Medical Training Source Type: news
Challenges and Benefits of Repurposing Products for Use during a Radiation Public Health Emergency: Lessons Learned from Biological Threats and other Disease Treatments.
This report reviews the information presented, as well as an overview of discussions from the meeting.
PMID: 30160600 [PubMed - as supplied by publisher]
Source: Radiation Research - August 30, 2018 Category: Physics Authors: DiCarlo AL, Cassatt DR, Dowling WE, Esker JL, Hewitt JA, Selivanova OM, Williams MS, Price PW Tags: Radiat Res Source Type: research
Data Age in Clinical Trials Is About Three Years at Publication
Trials funded by government were associated with significantly longer time to publication
Source: The Doctors Lounge - Psychiatry - September 11, 2018 Category: Psychiatry Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Nursing, Oncology, Ophthalmology, Orthopedics, ENT, Source Type: news
Challenges and Benefits of Repurposing Licensed/Approved/Cleared Products for a Radiation Indication.
Abstract
Increasingly, the risk of a radiological or nuclear public health emergency is a major concern for the U.S. government. To address a potential incident and ensure that the U.S. Government is prepared to respond to any civilian or military casualties that could result, the U.S. Department of Health and Human Services (HHS), together with the Department of Defense, has been charged with the development of medical countermeasures (MCMs) to treat individuals experiencing acute and delayed injuries that can result from exposure to radiation. With limited research and development budgets, and the high costs ass...
Source: Radiation Research - October 3, 2018 Category: Physics Authors: Price PW, DiCarlo AL Tags: Radiat Res Source Type: research
Study: 15 percent of babies exposed to Zika before birth had severe abnormalities in first 18 months of life
This study was supported by the National Institutes of Health ’s National Institute of Allergy and Infectious Diseases and National Eye Institute, the Thrasher Research Fund, the Bill and Melinda Gates Foundation Grand Challenges Explorations, and grants from government agencies and other funders in Brazil.
Source: UCLA Newsroom: Health Sciences - December 12, 2018 Category: Universities & Medical Training Source Type: news
Trump Wants to End HIV Within 10 Years. Here ’s What That Would Take, According to Experts
About 1.1 million Americans currently live with HIV, and approximately 40,000 are infected each year, according to federal data. But in his State of the Union address, President Donald Trump promised to “eliminate the HIV epidemic in the United States within 10 years” — a plan that hinges on a multi-agency push for better diagnosis, treatment and prevention in at-risk communities, health officials said Wednesday.
Trump introduced the plan during his annual address on Tuesday but offered few details. Health officials fleshed out the plan during a call with reporters on Wednesday.
The initiative will be ove...
Source: TIME: Health - February 6, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime HIV/AIDS onetime Source Type: news
Studies of Deadly Flu Virus, Once Banned, Are Set to Resume
The government will allow research on bird flu that had been halted over safety concerns. But officials have not publicly announced the decision nor explained how it was made.
Source: NYT Health - March 1, 2019 Category: Consumer Health News Authors: DENISE GRADY Tags: Research Accidents and Safety Avian Influenza Erasmus Medical Center Health and Human Services Department University of Wisconsin National Institutes of Health National Institute of Allergy and Infectious Diseases Madison (Wis) Rotterdam Source Type: news
Generating robust and informative nonclinical in vitro and in vivo bacterial infection model efficacy data to support translation to humans.
Abstract
In June 2017, The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, organized a workshop entitled "Pharmacokinetics-Pharmacodynamics (PK/PD) for Development of Therapeutics against Bacterial Pathogens". The aims were to discuss details of various PK/PD models and identify sound practices for deriving and utilizing PK/PD relationships to design optimal dosage regimens for patients. Workshop participants encompassed individuals from academia, industry and government, including the United States Food and Drug Administration. This and the accompanying review on ...
Source: Antimicrobial Agents and Chemotherapy - March 3, 2019 Category: Microbiology Authors: Bulitta JB, Hope W, Eakin AE, Guina T, Tam VH, Louie A, Drusano GL, Hoover JL Tags: Antimicrob Agents Chemother Source Type: research
Considerations for Dose Selection and Clinical Pharmacokinetics/Pharmacodynamics for the Development of Antibacterial Agents.
Abstract
In June 2017, The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, organized a workshop entitled "Pharmacokinetics-Pharmacodynamics (PK/PD) for Development of Therapeutics against Bacterial Pathogens" to discuss details and critical parameters of various PK/PD methods and identify approaches for linking human pharmacokinetic (PK) data and drug efficacy analyses. The workshop participants included individuals from academia, industry and government. This and the accompanying mini-review on nonclinical PK/PD summarize the workshop discussions and recommendatio...
Source: Antimicrobial Agents and Chemotherapy - March 3, 2019 Category: Microbiology Authors: Rizk ML, Bhavnani SM, Drusano G, Dane A, Eakin AE, Guina T, Jang SH, Tomayko JF, Wang J, Zhuang L, Lodise TP Tags: Antimicrob Agents Chemother Source Type: research
A Mysterious, Paralyzing Illness in Kids Is Worrying U.S. Health Officials: New Report
(NEW YORK) — One morning last fall, 4-year-old Joey Wilcox woke up with the left side of his face drooping.
It was the first sign of an unfolding nightmare.
Three days later, Joey was in a hospital intensive care unit, unable to move his arms or legs or sit up. Spinal taps and other tests failed to find a cause. Doctors worried he was about to lose the ability to breathe.
“It’s devastating,” said his father, Jeremy Wilcox, of Herndon, Virginia. “Your healthy child can catch a cold — and then become paralyzed.”
Joey, who survived but still suffers some of the effects, was one of 228...
Source: TIME: Health - April 2, 2019 Category: Consumer Health News Authors: MIKE STOBBE / AP Tags: Uncategorized illness medical onetime Source Type: news
P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages
This study has been funded by the Council of Scientific and Industrial Research (CSIR), New Delhi, India, vide grant no 37 (1542)/12/EMR-II and Department of Science and Technology (DST-SERB), New Delhi, India, vide grant no EMR/2016/000854. It was also supported by Institute of life sciences, Bhubaneswar, under Department of Biotechnology and National Institute of Science Education and Research (NISER), Bhubaneswar, under Department of Atomic Energy (DAE), Government of India.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships th...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research
Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF- β
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication.
Results and Discussion
TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcript...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research
