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Infectious Disease: Parasitic Diseases

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Total 613 results found since Jan 2013.

Toxoplasma gondii Infection Suppresses House Dust Mite Extract-Induced Atopic Dermatitis in NC/Nga Mice.
CONCLUSIONS: We have experimentally demonstrated for the first time that T. gondii infection ameliorated AD-like skin lesions in a mouse model of AD. Our study could in part explain the mechanisms of how parasite infection prevents the development of allergic disorder. Therefore, these immunemechanisms induced by T. gondii infection may be beneficial for the host in terms of reduced risk of allergic immune reactions. PMID: 26333702 [PubMed]
Source: Allergy, Asthma and Immunology Research - September 6, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Toxocara Canis IgG Seropositivity in Patients with Chronic Urticaria.
In this study, 73 patients diagnosed with CU and 109 healthy individuals as control group, were included. Various factors such as sex, age, education and income, daily hand washing habits, history of dog owning and soil eating were questioned in patient anamnesis. T. canis IgG antibodies were detected using an enzyme linked immunosorbent assay (ELISA) kit prepared with T. canis larval excretory-secretory antigens. Positive results were confirmed with western blot (WB) WB test.We found T. canis IgG positivity in 17.8% (n=13) of patients (n=73) with CU. But we did not observe any T. canis IgG positivity in healthy controls (...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 1, 2015 Category: Allergy & Immunology Authors: Burak-Selek M, Baylan O, Kutlu A, Özyurt M Tags: Iran J Allergy Asthma Immunol Source Type: research

The Promising Pharmacological Effects and Therapeutic/Medicinal applications of Punica Granatum L. (Pomegranate) as a Functional Food in Humans and Animals.
CONCLUSIONS: Present review gives the insight towards major components of pomegranate as well as their pharmacological activities against pathological disorders. In spite of many beneficial properties of Punica granatum L., more research evidence on molecular basis are needed to find out the molecular mechanism of action in various animals and human models to validate the usefulness of Punica granatum L. as a potent therapeutic agent. PMID: 29473532 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - February 24, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Effect of prolonged anti-HM1: IMSS Entamoeba histolytica antibody activity in Humoral and Cellular Immunity of experimentally induced animal model.
CONCLUSION: Thus our study demonstrated the efficacy of amoebic antigen in immune response mechanism and how they provoked inflammation and act as immunomodulator. This article also summarized some relevant patents with respect to E. histolytica against inflammation and other diseases. PMID: 29932039 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 24, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Infectious etiology of chronic diarrhea in patients with primary immunodeficiency diseases.
Conclusion. The current study suggests considering both usual and unusual pathogens in laboratory investigation and in the empiric treatment of chronic diarrhea. Opportunistic pathogens should be taken into account when no other pathogen is identified, especially in patients on long-term treatment or prophylaxis with antifungals/antibiotics and in those from geographical locations that favor pathogenicity of these organisms. PMID: 30417635 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - November 14, 2018 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Giardiasis : An overview.
CONCLUSION: Metronidazole, tinidazole, and nitazoxanide are the drugs of choice. Resistance to common antigiardial drugs has increased in recent years. As such, the search for new molecular targets for antigiardial drugs is urgently needed. In general, treatment of asymptomatic carriers is not recommended. Purification of water supply is an important preventive measure. PMID: 31210116 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 20, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Human Ascariasis: An Updated Review.
CONCLUSION: The average cure rate with anthelminthic treatment is over 95%. Unfortunately, most treated patients in endemic areas become re-infected within months. Health education, personal hygiene, improved sanitary conditions, proper disposal of human excreta, and discontinuing the use of human fecal matter as a fertilizer are effective long-term preventive measures. Targeting deworming treatment and mass anthelminthic treatment should be considered in regions where A. lumbricoides is prevalent. PMID: 32628606 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 7, 2020 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

An Unexpected Infection in Loss-of-Function Mutations in STAT3: Malignant Alveolar Echinococcosis in Liver.
Abstract Loss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) gene causes autosomal dominant hyper immunoglobulin E syndrome (AD-HIES or Job's Syndrome), a rare and complex primary immunodeficiency (PID) syndrome characterized by increased levels of IgE (>2000 IU/mL), eosinophilia, recurrent staphylococcal skin abscesses, eczema, recurrent pneumonia, skeletal and connective tissue abnormalities. Although bacterial and fungal infections are common in AD-HIES, susceptibility to parasitic infections has not been reported. Alveolar echinococcosis (AE), a zoonosis caused by ...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2020 Category: Allergy & Immunology Authors: Haskologlu S, Dogu F, Gollu Bahadır G, Akyuzluer S, Ciftci E, Altun D, Keles S, Kologlu M, Ikinciogullari A Tags: Iran J Allergy Asthma Immunol Source Type: research

Predictive Value of Serum Interleukins in Children with Idiopathic Nephrotic Syndrome.
This study was performed to identify alteration of different serum interleukins (ILs) in children with INS, and their predictive value in response to steroid treatment. Three groups of children (27; steroid-sensitive INS, 21; steroid-resistant INS, and 19 healthy controls) with normal serum C3, negative serologic tests of hepatitis B virus (HBV), hepatitis C virus (HCV), human immune deficiency virus (HIV), and parasitic infections were included in this study. Serum concentrations of IL-1β, IL-2, IL-6, IL-8, IL-13, and IL-18 were measured, using quantitative colorimetric sandwich ELISA kits. Children with secondary nephro...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2020 Category: Allergy & Immunology Authors: Nickavar A, Valavi E, Safaeian B, Amoori P, Moosavian M Tags: Iran J Allergy Asthma Immunol Source Type: research

Nutritional status, intestinal parasite infection and allergy among school children in Northwest Ethiopia
Conclusion: The prevalence of malnutrition, intestinal parasitism and allergy was not negligible in this population. In addition, there was no significant association between the prevalence of allergy and their nutritional status, and parasite infection. Further research prospective observational and intervention studies are required to address the question of causality between nutritional factors, parasites, and allergy.
Source: BioMed Central - January 12, 2013 Category: Journals (General) Authors: Bemnet AmareJemal AliBeyene MogesGizachew YismawYeshambel BelyhunSimon GebretsadikDesalegn WoldeyohannesKetema TafessEbba AbateMengistu EndrisDesalegn TegabuAndargachew MuluFusao OtaAfework KassuBereket Fantahun Source Type: research

The Role of Helminth Infection and Environment in the Development of Allergy: A Prospective Study of Newly-Arrived Ethiopian Immigrants in Israel
by Miguel Stein, Zalman Greenberg, Mona Boaz, Zeev T. Handzel, Mesfin K. Meshesha, Zvi Bentwich Helminth infection may be protective against allergy and account for the low prevalence of allergy in developing countries. We studied prospectively the prevalence of allergy in Ethiopian immigrants with heavy helminth infection on arrival in Israel, and again after a year of adjustment to an urban industrialized setting, to explore the roles of helminth infection, changed environment and background immunity on the manifestations of allergy. 126 newly arrived Ethiopian immigrants were studied at baseline and 115 after a year of...
Source: PLoS Neglected Tropical Diseases - January 11, 2016 Category: Tropical Medicine Authors: Miguel Stein et al. Source Type: research

Immuno-evasive tactics by schistosomes identifies an effective allergy preventative.
Abstract Many chronic inflammatory diseases can be improved by helminth infection, but the mechanisms are poorly understood. Allergy and helminthiasis are both associated with Th2-like immune responses; thus, defining how infection with parasites leads to reduced allergy has been particularly challenging. We sought to better understand this conundrum by evaluating host-parasite interactions involved in Th2 immunity in human schistosomiasis. Immune cells were cultured with schistosomes and the effect on CD23, an IgE receptor associated with resistance in schistosomiasis, was evaluated. Cells treated with schistosom...
Source: Experimental Parasitology - March 24, 2015 Category: Parasitology Authors: Griffith Q, Liang Y, Whitworth P, Rodriguez-Russo C, Gul A, Siddiqui AA, Connor J, Mwinzi P, Ganley-Leal L Tags: Exp Parasitol Source Type: research

Schistosoma infection is negatively associated with mite atopy, but not wheeze and asthma in Ghanaian Schoolchildren
Conclusion and Clinical RelevanceInfection with Schistosoma appeared to protect against mite SPT reactivity. This needs to be confirmed in future studies, preferably in a longitudinal design where schistosome infections are treated and allergic reactions re‐assessed.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - March 1, 2014 Category: Allergy & Immunology Authors: Benedicta B. Obeng, Abena S. Amoah, Irene A. Larbi, Dziedzom K. Souza, Hae‐Won Uh, Montserrat Fernandez‐Rivas, Ronald Ree, Laura C Rodrigues, Daniel A. Boakye, Maria Yazdanbakhsh, Franca C. Hartgers Tags: Original Article‐Epidemiology of Allergic Disease Source Type: research

Schistosome infection is negatively associated with mite atopy, but not wheeze and asthma in Ghanaian Schoolchildren
Conclusion and Clinical RelevanceInfection with schistosomes appeared to protect against mite SPT reactivity. This needs to be confirmed in future studies, preferably in a longitudinal design where schistosome infections are treated and allergic reactions reassessed.
Source: Clinical and Experimental Allergy - June 23, 2014 Category: Allergy & Immunology Authors: B. B. Obeng, A. S. Amoah, I. A. Larbi, D. K. Souza, H.‐W. Uh, M. Fernández‐Rivas, R. Ree, L. C. Rodrigues, D. A. Boakye, M. Yazdanbakhsh, F. C. Hartgers Tags: Original Article Source Type: research

Oocyst-Derived Extract of Toxoplasma Gondii Serves as Potent Immunomodulator in a Mouse Model of Birch Pollen Allergy
Conclusion Our data demonstrate that pretreatment with the oocyst extract can exert anti-allergic effects comparable to T. gondii infection. Thus, the immunomodulatory properties of the parasite extract indicate that this extract and in the future defined molecules thereof might serve as immunomodulatory adjuvants in allergy treatment and prophylaxis.
Source: PLoS One - May 4, 2016 Category: Biomedical Science Authors: Angelika Wagner Source Type: research