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Infectious Disease: Herpes
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Total 364 results found since Jan 2013.
Relationship between glucocorticoid dose and adverse events in systemic lupus erythematosus: data from a randomized clinical trial.
CONCLUSION: This study highlights the feasibility of post-hoc analyses of RCTs using the SHARE mechanism and demonstrates the association of GCs with various AEs. Contrary to expectations, there were also associations between lower cumulative GC dose and several other AEs.
PMID: 28862513 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - September 1, 2017 Category: Rheumatology Authors: Emamikia S, Gentline C, Chatzidionysiou K, Arnaud L, van Vollenhoven R Tags: Scand J Rheumatol Source Type: research
Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial
Publication date: Available online 27 September 2017 Source:The Lancet Global Health Author(s): Ranjeeta Thomas, Ronelle Burger, Abigail Harper, Sarah Kanema, Lawrence Mwenge, Nosivuyile Vanqa, Nomtha Bell-Mandla, Peter C Smith, Sian Floyd, Peter Bock, Helen Ayles, Nulda Beyers, Deborah Donnell, Sarah Fidler, Richard Hayes, Katharina Hauck Background The life expectancy of HIV-positive individuals receiving antiretroviral therapy (ART) is approaching that of HIV-negative people. However, little is known about how these populations compare in terms of health-related quality of life (HRQoL). We aimed to compare HRQoL betwee...
Source: The Lancet Global Health - September 28, 2017 Category: International Medicine & Public Health Source Type: research
CD4 T cell –restricted IL-2 signaling defect in a patient with a novel IFNGR1 deficiency
A female child was referred to our institution at age 20 months after a protracted course of a febrile illness and cough associated with radiographic findings, demonstrating a large necrotic suprahilar lymph node impinging on the right main stem bronchus. Culture of the lymph node biopsy specimen, blood, and sputum identified Mycobacterium fortuitum an d Mycobacterium avium complex, whereas bronchoalveolar lavage specimen culture revealed the presence of Moraxella species. Other clinical findings included severe eczema for the first 6 months of life that was controlled by emollient use, development of chicken pox after...
Source: Journal of Allergy and Clinical Immunology - September 16, 2017 Category: Allergy & Immunology Authors: Aaruni Khanolkar, Dawn A. Kirschmann, Edward A. Caparelli, Jeffrey D. Wilks, Jillian M. Cerullo, Jenna R.E. Bergerson, Lawrence J. Jennings, Ramsay L. Fuleihan Tags: Letter to the Editor Source Type: research
Patients with atopic dermatitis and history of eczema herpeticum elicit HSV-specific type 2 immune responses
An increased type 2 and in parallel decreased type 1 T cell immune response to herpes simplex virus 1 may lead to the clinical phenotype of eczema herpeticum.
Source: Journal of Allergy and Clinical Immunology - November 15, 2017 Category: Allergy & Immunology Authors: Stephan Traidl, Petra Kienlin, Gabriele Begemann, Lichen Jing, David M. Koelle, Thomas Werfel, Lennart M. Roesner Source Type: research
Dermatological Complications After Solid Organ Transplantation
AbstractOrgan transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e.g., malignant melanoma. It also offers an opport...
Source: Clinical Reviews in Allergy and Immunology - November 25, 2017 Category: Allergy & Immunology Source Type: research
Patients with atopic dermatitis and history of eczema herpeticum elicit herpes simplex virus –specific type 2 immune responses
Atopic dermatitis (AD) is an inflammatory, relapsing skin disorder that affects 15% to 25% of children worldwide and persists in adulthood in around 25% of these cases.1 About 3% to 8% of patients with AD seem to have a disturbance in viral clearance, manifesting severe forms of molluscum contagiosum, papilloma virus, and most prominently, the generalized cutaneous infection with herpes simplex virus 1 (HSV1), called eczema herpeticum (EH),2,E1,E2 which can lead to life-threatening complications.
Source: Journal of Allergy and Clinical Immunology - November 15, 2017 Category: Allergy & Immunology Authors: Stephan Traidl, Petra Kienlin, Gabriele Begemann, Lichen Jing, David M. Koelle, Thomas Werfel, Lennart M. Roesner Tags: Letter to the Editor Source Type: research
Current Perspectives on Erythema Multiforme
AbstractRecognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythematous lesions with predominant acral localization as well as histological findings. Clinically, erythema multiforme can be differentiated into isolated cutaneous and combined mucocutaneous form...
Source: Clinical Reviews in Allergy and Immunology - January 19, 2018 Category: Allergy & Immunology Source Type: research
ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum
Atopic dermatitis (AD) is a common inflammatory skin disease. A subset of AD is susceptible to disseminated herpes simplex virus (HSV) infection, a complication termed as eczema herpeticum(ADEH+). The immune mechanisms causing ADEH+ remain elusive. Using RNA-sequencing, we recently found that ankyrin repeat domain 1 (ANKRD1) was significantly induced in human peripheral blood mononuclear cells (PBMCs) upon HSV-1 stimulation; and its induction in ADEH+ was significantly reduced as compared to AD patients without a history of EH (ADEH-).
Source: Journal of Allergy and Clinical Immunology - January 23, 2018 Category: Allergy & Immunology Authors: Lianghua Bin, Xiaozhao Li, Brittany Richers, Joanne E. Streib, Jack W. Hu, Patricia Taylor, Donald Y.M. Leung Source Type: research
Safety And Efficacy Of Dupilumab In Adult Patients With A History Of Eczema Herpeticum
Eczema herpeticum is not uncommon in patients with severe eczema. Prior studies have showed an increase rate of some herpes simplex exacerbation (oral ulcers) in retrospective analysis of patients treated with dupilumab versus placebo but no increase in eczema herpeticum. Efficacy and side effects of dupilumab, recently FDA approved for severe eczema, have not been reported in patients with a prior history of eczema
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Jette Hooper, Brian Weeks, David H. Dreyfus Source Type: research
Incidence of reactivated Herpes Zoster (shingles) in patients with Primary Immune Deficiency
To determine the incidence and associated features of reactivated Herpes Zoster (shingles) in a cohort of patients with primary immune deficiency diseases (PIDD).
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: David S. Lindsay, Charlotte Cunningham-Rundles, Ramsay L. Fuleihan, Mark Ballow, Jennifer W. Leiding Source Type: research
Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum
Atopic dermatitis (AD) is a common inflammatory skin disease. A subset of patients with AD are susceptible to disseminated herpes simplex virus (HSV) infection, a complication termed eczema herpeticum (ADEH+). The immune mechanisms causing ADEH+ remain elusive. Using RNA sequencing, we recently found that ankyrin repeat domain 1 (ANKRD1) was significantly ind uced in human PBMCs upon HSV-1 stimulation, and its induction in patients with ADEH+ was significantly reduced compared with that seen in AD patients without a history of eczema herpeticum (ADEH−).
Source: Journal of Allergy and Clinical Immunology - January 23, 2018 Category: Allergy & Immunology Authors: Lianghua Bin, Xiaozhao Li, Brittany Richers, Joanne E. Streib, Jack W. Hu, Patricia Taylor, Donald Y.M. Leung Source Type: research
Exploration of (hetero)aryl derived thienylchalcones for antiviral and anticancer activities.
CONCLUSION: Compounds V and VI were demonstrated viral inhibition towards Human cytomegalovirus, whereas cyclopropylquinoline derivative IV towards Rift Valley fever virus and Tacaribe virus. Additionally, cyclopropylquinoline derivative IV has displayed very good cytotoxicity against colon, breast and leukemia cell lines in vitro.
PMID: 29792154 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - May 23, 2018 Category: Chemistry Authors: Patil V, Patil SA, Patil R, Bugarin A, Beaman K, Patil SA Tags: Med Chem Source Type: research
Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection
Mutations disrupting the Toll-like receptor 3 (TLR3) –dependent–interferon pathway can underlie herpes simplex encephalitis (HSE) of childhood caused by herpes simplex virus 1 (HSV1) infection. These otherwise healthy patients with HSE carry germline mutations in the TLR3-interferon circuit, including TIR domain–containing adapter–inducing IFN -β (TRIF) and TANK-binding kinase 1 (TBK1).1,2 Their dermal fibroblasts show impaired interferon production after HSV1 infection and polyinosinic-polycytidylic acid (poly[I:C]) stimulation.
Source: Journal of Allergy and Clinical Immunology - October 5, 2018 Category: Allergy & Immunology Authors: Liyana Ahmad, Bayarchimeg Mashbat, Corwin Leung, Charlotte Brookes, Samar Hamad, Sina Krokowski, Avinash R. Shenoy, Lazaro Lorenzo, Michael Levin, Peter O'Hare, Shen-Ying Zhang, Jean-Laurent Casanova, Serge Mostowy, Vanessa Sancho-Shimizu Tags: Letter to the Editor Source Type: research
Fever and respiratory distress in an infant: mannose-binding lectin deficiency?
We present an infant with multiple infections who was diagnosed with MBL deficiency.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: K. Reddy, S. Alagheband, L. Schmidt, A. Yates Tags: M272 Source Type: research
