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New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Is This Sarcoidosis?
Discussion Sarcoidosis is rare and is even rarer in the pediatric age group. Sarcoidosis is seen in all ages with an estimated prevalence is 10-40/100,000 in the U.S. population. Pediatric sarcoidosis has an estimated incidence of 0.2/100,000 per year. For the pediatric age range it is more likely from 9-15 years of age. In adults it commonly presents between 20-39 years but bimodal distribution is also reported. Women are more likely to have sarcoidosis than men. African American females have the highest risk, and usually present slightly older, especially in the 4th decade of life. African American women are also more li...
Source: PediatricEducation.org - May 6, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

How Common Is Hereditary Angioedema?
Discussion Angioedema is edema that is non-pitting, self-limited occurring in non-dependent areas usually in an asymmetric distribution usually on the lips, face, hands, feet, genitals and also in the bowel. It usually develops over minutes to hours (often 1-2 hours) with resolution usually within 24-48 hours. Angioedema often occurs with urticaria but 20% of patients may have isolated angioedema. Acute allergic angioedema is often caused by drugs (including antibiotics and non-steroidal anti-inflammatory drugs), foods, infections, insects, various organic substances (i.e. latex, preservatives, formaldehyde, etc.), and oth...
Source: PediatricEducation.org - October 9, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Cardiac involvement in DRESS syndrome
Conclusions: According to its high morbidity and mortality, patients with DRESS syndrome should be carefully monitored or screened for cardiac involvement. Multidisciplinary care is important for a successful treatment outcome.
Source: Asian Pacific Journal of Allergy and Immunology - December 18, 2016 Category: Allergy & Immunology Source Type: research

The Management of Autoimmune Hepatitis Patients with Decompensated Cirrhosis: Real-World Experience and a Comprehensive Review
In this study, we sought to determine the therapeutic effect of corticosteroids in this special group of AIH patients. Eighty-two AIH patients with decompensated cirrhosis were included through a retrospective analysis from January 2009 to September 2015. Sixty-four patients were treated with corticosteroids while 18 patients did not receive any corticosteroids. Clinical, laboratory, and histological characteristics and outcomes were analyzed comparing corticosteroid-treated and untreated groups. Patients that did not receive corticosteroids were older than corticosteroid-treated patients and had a worse survival. In corti...
Source: Clinical Reviews in Allergy and Immunology - August 10, 2016 Category: Allergy & Immunology Source Type: research

Drug-induced hypersensitivity syndrome: recent advances in the diagnosis, pathogenesis and management.
Authors: Shiohara T, Kano Y, Takahashi R, Ishida T, Mizukawa Y Abstract Drug-induced hypersensitivity syndrome (DIHS), also referred to as drug reaction with eosinophilia with systemic symptoms, is a life-threatening multiorgan system reaction caused by a limited number of drugs such as anticonvulsants. This syndrome is characterized by fever, rash, lymphadenopathy, hepatitis, and leukocytosis with eosinophilia. DIHS has several unique features that include the delayed onset, paradoxical deterioration of clinical symptoms after withdrawal of the causative drug and unexplained cross-reactivity to multiple drugs with...
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Diagnostics and Treatment of Cryoglobulinaemia: It Takes Two to Tango
Abstract Cryoglobulins are immunoglobulins that reversibly precipitate in the cold. They come in different flavours and, as such, are differentially associated with lymphoproliferative diseases (type I), or systemic autoimmune diseases, and/or infectious diseases (type II/III). The clinical manifestations of cryoglobulinaemia result from either hyper-viscosity or small vessel vasculitis. Hepatitis C virus (HCV) is a well-known factor in the aetiology of cryoglobulinaemia, but substantial geographical differences exist in the association between cryoglobulins and HCV. In the absence of any underlying disease, cryo...
Source: Clinical Reviews in Allergy and Immunology - November 21, 2014 Category: Allergy & Immunology Source Type: research

Incidence and Management of Rash in Telaprevir-Treated Patients: Lessons for Simeprevir?
CONCLUSIONS: ABW and BMI appear to be related to rash development. This finding may have implications in the treatment of HCV with simeprevir, given its similarity to telaprevir. PMID: 24939632 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - June 17, 2014 Category: Drugs & Pharmacology Authors: Smith MA, Johnson HJ, Chopra KB, Dunn MA, Ulrich AM, Mohammad RA Tags: Ann Pharmacother Source Type: research

Rituximab for tumefactive demyelination refractory to corticosteroids and plasma exchange
Case history A 38-year-old woman with no significant past medical history presented with a generalised tonic–clonic seizure. The patient was afebrile and general physical and neurological examinations were normal. MRI of the brain revealed an irregular mass in the right temporal lobe with T2-weighted and fluid-attenuated inversion recovery (FLAIR) signal hyperintensity and heterogeneous enhancement after the administration of gadolinium (figure 1A–D). Laboratory investigations included normal blood count, liver enzymes, serum creatinine, angiotensin converting enzyme and erythrocyte sedimentation rate (ESR). Se...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 13, 2013 Category: Neurosurgery Authors: Sempere, A. P., Feliu-Rey, E., Sanchez-Perez, R., Nieto-Navarro, J. Tags: Immunology (including allergy), HIV/AIDS, Cranial nerves, Drugs: CNS (not psychiatric), Epilepsy and seizures, Headache (including migraine), Multiple sclerosis, Neurooncology, Pain (neurology), CNS cancer, Ophthalmology, Radiology, Surgical diagnostic te Source Type: research

Managing generalized interferon‐induced eruptions and the effectiveness of desensitization
ConclusionsOur study demonstrates the benefit of allergy testing in cases of generalized drug reactions to IFN, cross‐reactivities in a single class of IFNs, and the importance of delayed IDT reading. We report for the first time the effectiveness of 12 step desensitization with peg‐IFN.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - October 15, 2013 Category: Allergy & Immunology Authors: Claire Poreaux, Jean‐Pierre Bronowicki, Marc Debouverie, Jean‐Luc Schmutz, Julie Waton, Annick Barbaud Tags: Original Article‐Clinical Allergy Source Type: research

In patients with a first episode of severe alcoholic hepatitis non-responsive to medical therapy, early liver transplant increases 6-month survival
Commentary on: Mathurin P, Moreno C, Samuel D, et al.. Early liver transplantation for severe alcoholic hepatitis. N Engl J Med 2011;365:1790–800. Context In its most severe form, alcoholic hepatitis is associated with jaundice, coagulopathy, leucocytosis and rapid deterioration to death.1 When used in conjunction with abstinence from alcohol, corticosteroids improve 6-month survival for such severely affected patients.2 Treatment failures are identified after 7 days of therapy, using a simple mathematical instrument (http://www.lillemodel.com).3 Patients with alcoholic hepatitis who are unresponsive to medical manag...
Source: Evidence-Based Medicine - January 17, 2013 Category: Internal Medicine Authors: Lucey, M. R. Tags: Liver disease, Epidemiologic studies, Immunology (including allergy), Hepatitis and other GI infections, Radiology, Hepatitis (sexual health), Surgical diagnostic tests, Clinical diagnostic tests Therapeutics Source Type: research

Disseminated Mycobacterium genavense infection after immunosuppressive therapy shows underlying new composite heterozygous mutations of β1 subunit of IL-12 receptor gene
We describe a 35-year-old white Italian female patient with abdominal lymphadenopathy and diarrhea who had received immunosuppressive therapy with corticosteroids and azathioprine since the age of 23 because of type I autoimmune chronic hepatitis associated with α1-antitrypsin deficiency (genotype MZ). This diagnosis was based on positivity to autoantibodies and liver biopsy that showed portal and periportal lymphoplasmacytic infiltrates with bridging necrosis. In the same liver biopsy periodic acid-Schiff diastase staining showed diastase-resistant pink globules associated with immunoreactivity for α1-antitrypsin.
Source: Journal of Allergy and Clinical Immunology - July 23, 2012 Category: Allergy & Immunology Authors: Laura Tassone, Anna Cristina C. Carvalho, Alessandra Calabresi, Enrico Tortoli, Alessandra Apostoli, Omar Scomodon, Cecilia Spina, Donatella Vairo, Vincenzo Villanacci, Alberto Matteelli, Raffaele Badolato Tags: Letters to the Editor Source Type: research