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In silico Identification and Mechanism Exploration of Hepatotoxic Ingredients in Traditional Chinese Medicine
Conclusion: Overall, this study provides a high accurate approach to predict HILI and an in silico perspective into understanding the hepatotoxicity mechanism of TCM, which might facilitate the discovery and development of new drugs. Introduction Liver injury induced by drug, novel foods or phytotherapy, also known as hepatotoxicity, is still a major clinical and pharmaceutical concern (Amadi and Orisakwe, 2018; Hammann et al., 2018; Kyawzaw et al., 2018; Real et al., 2018). According to the data from United States National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), hepatotoxicity accounts for...
Source: Frontiers in Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Parental Vaccine Hesitancy in Quebec (Canada)
This study aims to contribute to the ongoing reflections on tools and indicators of vaccine hesitancy by providing results of a survey on knowledge, attitudes and beliefs (KAB) of parents in Quebec (Canada). We have compared KAB of parents according to: 1) self-reported vaccination status of their child and 2) hesitation during the vaccination decision. Methods Data were collected through the 2014 Quebec study on vaccination against seasonal influenza and pneumococcal infections, a biennial repeated cross-sectional study in the province of Quebec, Canada. This paper presents the results pertaining to parents’ KAB about ...
Source: PLOS Currents Outbreaks - March 7, 2016 Category: Epidemiology Authors: evedube Source Type: research

Safety and efficacy of angiographic occlusion of duodenal varices as an alternative to TIPS: review of 32 cases.
CONCLUSIONS: This work suggests that angiographic-occlusion-withsclerotherapy/ embolotherapy-without-TIPS is relatively effective (~90% hemostasis-rate), and relatively safe (3% major-complication-rate). This therapy may be a useful treatment option for duodenal varices when endoscopic therapy fails and TIPS is relatively contraindicated. PMID: 25864218 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - April 13, 2015 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The Clinical Value of Oxymatrine in Preventing Lamivudine Induced YMDD Mutation: A Meta-Analysis.
Authors: He M, Wu Y, Wang M, Chen W, Yuan W, Jiang J Abstract Oxymatrine (OMTR) is widely used for the treatment of chronic hepatitis B (CHB) in China. Several reports revealed that combination of OMTR and lamivudine reduced the incidence of tyrosine- (Y-) methionine- (M-) aspartic acid- (D-) aspartic acid (D) (YMDD) mutations in CHB patients. The aim of this study was to evaluate the clinical value of oxymatrine in preventing lamivudine induced YMDD mutation using meta-analysis of data from published randomized controlled trials (RCTs) and to provide some useful information for clinical treatment and future resear...
Source: Evidence-based Complementary and Alternative Medicine - November 1, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Literature review of liver injury induced by Tinospora crispa associated with two cases of acute fulminant hepatitis.
CONCLUSIONS: We concluded that people might cause hepatic injury or even death without correctly identifying these two Tinospora species. PMID: 30670256 [PubMed - in process]
Source: Complementary Therapies in Medicine - January 25, 2019 Category: Complementary Medicine Authors: Huang WT, Tu CY, Wang FY, Huang ST Tags: Complement Ther Med Source Type: research

Case series of an alternative therapy for generalised lichen planus: Four case studies.
Authors: Nwabudike LC, Miulescu M, Tatu AL Abstract Lichen planus (LP) is an idiopathic, cell-mediated immune disorder, accompanied by itching. Spontaneous remission occurs. Topical and systemic therapies are utilised. Four cases of generalized LP with and without mucosal involvement treated homeopathically are presented. Case 1: A 48-year-old female presented with a 7-month history of generalized itchy rash, which had been diagnosed as LP, treated unsuccessfully with topical steroids and removal of dental fillings. Examination revealed violaceous papules on upper and lower limbs, oral mucosal lesions and an irregu...
Source: Experimental and Therapeutic Medicine - August 8, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Advance in studies on traditional Chinese medicines to treat infection with the hepatitis B virus and hepatitis C virus.
Authors: Xia J, Inagaki Y, Song P, Sawakami T, Kokudo N, Hasegawa K, Sakamoto Y, Tang W Abstract Traditional Chinese medicine (TCM), as a type of complementary and alternative medicine (CAM), is a sophisticated and time-honored form of healthcare in China. Many TCMs are widely used to treat hepatitis B and hepatitis C in countries like China, Japan, and South Korea. Since conventional clinical preparations like interferon-α cause obvious dose-dependent adverse reactions and drug resistance, TCMs and related bioactive compounds have garnered increasing attention from physicians and medical researchers. Thus far, a ...
Source: BioScience Trends - June 30, 2016 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The Use of Hijama (Wet Cupping) in Alternative and Complementary Medicine: Efficacious or Perilous?
Publication date: Available online 10 September 2016 Source:Journal of Acupuncture and Meridian Studies Author(s): Syed Mohammad Mazhar Uddin, Aatera Haq, Haris Sheikh The field of medicine has remained an extensive ground for major advancements over recent decades with the primary purpose of reducing the suffering of humanity and improving the course of life. However, despite these modern advancements, the popularity of complementary and alternative medicine (CAM) has increased. The use of CAM in many developed and developing countries is considerable. One such example of CAM is Hijama, which literally means sucking (cup...
Source: Journal of Acupuncture and Meridian Studies - September 10, 2016 Category: Complementary Medicine Source Type: research

Chinese Herbal Medicine Ameliorated the Development of Chronic Kidney Disease in Patients with Chronic Hepatitis C: A Retrospective Population-Based Cohort Study.
This study showed that the patients suffering from hepatitis C with CHM treatment more than 90 days as an adjuvant therapy combined with western medical treatment modalities exhibited a decreased risk of developing CKD (hazard ratio (HR) = 0.40, 95% confidence interval (CI) = 0.21-0.76, p value <0.01). The Kaplan-Meier curve revealed a lower cumulative incidence rate of CKD (p value = 0.004) for the CHM cohort. For further reference, we herein offer the ten most frequently prescribed single herbs and herbal formulas; as such, Salviae miltiorrhizae and Jia-Wei-Xiao-Yao-San were the most commonly prescribed si...
Source: Evidence-based Complementary and Alternative Medicine - December 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Clinical Efficacy and Safety of Tenofovir in the Treatment of Patients with Chronic Hepatitis B
Conclusion. Tenofovir is more effective than entecavir in the treatment of patients with CHB due to low incidence of adverse events and a good safety profile.PMID:35774746 | PMC:PMC9239785 | DOI:10.1155/2022/1673453
Source: Evidence-based Complementary and Alternative Medicine - July 1, 2022 Category: Complementary Medicine Authors: Feng He Zhongjiang Xia Hui Wang Jinjun Zhu Laiwen Hu Source Type: research

A Comprehensive Nursing Model Combined with High-Quality Nursing Intervention for Antiviral Therapy in Patients with Chronic Hepatitis B
CONCLUSION: The comprehensive nursing model combined with high-quality nursing intervention improves the psychological state and compliance of patients with chronic hepatitis B, with favorable treatment efficiency, which shows good potential for clinical promotion.PMID:35979008 | PMC:PMC9377886 | DOI:10.1155/2022/6244637
Source: Evidence-based Complementary and Alternative Medicine - August 18, 2022 Category: Complementary Medicine Authors: Wei Yang Xiaofeng Tian Jing Liang Source Type: research

Scientists Say They ’ve Reached ‘Turning Point’ in Cancer Research With Vaccines
SEATTLE — The next big advance in cancer treatment could be a vaccine. After decades of limited success, scientists say research has reached a turning point, with many predicting more vaccines will be out in five years. These aren’t traditional vaccines that prevent disease, but shots to shrink tumors and stop cancer from coming back. Targets for these experimental treatments include breast and lung cancer, with gains reported this year for deadly skin cancer melanoma and pancreatic cancer. “We’re getting something to work. Now we need to get it to work better,” said Dr. James Gulley, who help...
Source: TIME: Health - June 26, 2023 Category: Consumer Health News Authors: Carla K. Johnson / AP Tags: Uncategorized Cancer wire Source Type: news

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