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Infectious Disease: Epidemics
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Total 37293 results found since Jan 2013.
CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection
In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre in mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713
Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research
Bangladesh's 2023 Dengue outbreak – age/gender-related disparity in morbidity and mortality and geographic variability of epidemic burdens
Bangladesh is currently grappling to control its most devastating dengue fever outbreak recorded since the dengue virus (DENV) reappeared in the country in 2000 [1 –3]. Although dengue is endemic in Bangladesh, the current dengue surge is unusual in terms of case burden and mortality, seasonality, and the early sharp increase [1]. Between 1 January and 25 August 2023, a total of 110,224 DENV infections including 528 deaths (case fatality ratio [CFR]: 0.48%) were recorded [2]. The reported number of dengue cases and deaths this year so far is already the highest ever recorded in the country, while the numbers are continuing to rise [1–3].
Source: International Journal of Infectious Diseases - September 1, 2023 Category: Infectious Diseases Authors: Najmul Haider, Md Asaduzzaman, Mohammad Nayeem Hassan, Mahbubur Rahman, Ahmed Raihan Sharif, Shah Ali Akbar Ashrafi, Shui Shan Lee, Alimuddin Zumla Tags: Editorial Source Type: research
As cannabis laws relax, neuroscientist warns of its dangers for developing brain
One morning in June, barely 5 months after the first dispensary for recreational cannabis opened in New York state, neuroscientist Yasmin Hurd spoke via Zoom to an audience of educators and specialists who work with or run programs for children. The session’s organizers, alarmed by how many children in their South Bronx community were now getting their hands on cannabis, had sought Hurd’s expertise on the drug’s effects.
Hurd put up a slide of the human brain, its bumps and grooves tinged blue, green, yellow, and red to indicate the distribution of the receptors to which tetrahydrocannabinol (THC), the psychoact...
Source: Science of Aging Knowledge Environment - August 31, 2023 Category: Geriatrics Source Type: research
Silences and Omissions in Reporting Epidemics in Russian and Soviet Prisons, 1890-2021
J Hist Med Allied Sci. 2023 Aug 31:jrad047. doi: 10.1093/jhmas/jrad047. Online ahead of print.ABSTRACTPenitentiary systems serve as breeding grounds for all kinds of diseases. Drawing upon new archival materials, this article examines the history of the management and reporting of epidemics in the Russian prison system from the late Imperial period to the present day. We use the case studies of cholera (1892-1893), typhus (1932-1933), and pulmonary tuberculosis (the 1990s) to examine how the general political and social conjuncture at different times affected the response of prison authorities to epidemics to show that, no...
Source: Medical History - August 31, 2023 Category: History of Medicine Authors: Mikhail Nakonechnyi Judith Pallot Source Type: research
Integrating Big Data and Assistive Technology to Improve College Students' Public Mental Health Quality During the COVID-19 Pandemic
J Autism Dev Disord. 2023 Aug 31. doi: 10.1007/s10803-023-06095-3. Online ahead of print.ABSTRACTThe Corona Virus Disease 2019 (COVID-19) suddenly broke out in a large area in December 2019, and now it has become a "global pandemic". The World Health Organization (WHO) defines COVID-19 as a serious global public health emergency of high international concern. In the context of epidemic prevention and control, some universities adopt the method of students staying at home and online teaching by teachers. Faced with changes in the learning environment, interpersonal environment, and social environment, some university studen...
Source: Journal of Autism and Developmental Disorders - August 31, 2023 Category: Psychiatry Authors: Fangling Yang Meiying Ni Xiaoying Bian Mei Liu Source Type: research
Silences and Omissions in Reporting Epidemics in Russian and Soviet Prisons, 1890-2021
J Hist Med Allied Sci. 2023 Aug 31:jrad047. doi: 10.1093/jhmas/jrad047. Online ahead of print.ABSTRACTPenitentiary systems serve as breeding grounds for all kinds of diseases. Drawing upon new archival materials, this article examines the history of the management and reporting of epidemics in the Russian prison system from the late Imperial period to the present day. We use the case studies of cholera (1892-1893), typhus (1932-1933), and pulmonary tuberculosis (the 1990s) to examine how the general political and social conjuncture at different times affected the response of prison authorities to epidemics to show that, no...
Source: Medical History - August 31, 2023 Category: History of Medicine Authors: Mikhail Nakonechnyi Judith Pallot Source Type: research
Integrating Big Data and Assistive Technology to Improve College Students' Public Mental Health Quality During the COVID-19 Pandemic
J Autism Dev Disord. 2023 Aug 31. doi: 10.1007/s10803-023-06095-3. Online ahead of print.ABSTRACTThe Corona Virus Disease 2019 (COVID-19) suddenly broke out in a large area in December 2019, and now it has become a "global pandemic". The World Health Organization (WHO) defines COVID-19 as a serious global public health emergency of high international concern. In the context of epidemic prevention and control, some universities adopt the method of students staying at home and online teaching by teachers. Faced with changes in the learning environment, interpersonal environment, and social environment, some university studen...
Source: Journal of Autism and Developmental Disorders - August 31, 2023 Category: Psychiatry Authors: Fangling Yang Meiying Ni Xiaoying Bian Mei Liu Source Type: research
Silences and Omissions in Reporting Epidemics in Russian and Soviet Prisons, 1890-2021
J Hist Med Allied Sci. 2023 Aug 31:jrad047. doi: 10.1093/jhmas/jrad047. Online ahead of print.ABSTRACTPenitentiary systems serve as breeding grounds for all kinds of diseases. Drawing upon new archival materials, this article examines the history of the management and reporting of epidemics in the Russian prison system from the late Imperial period to the present day. We use the case studies of cholera (1892-1893), typhus (1932-1933), and pulmonary tuberculosis (the 1990s) to examine how the general political and social conjuncture at different times affected the response of prison authorities to epidemics to show that, no...
Source: Medical History - August 31, 2023 Category: History of Medicine Authors: Mikhail Nakonechnyi Judith Pallot Source Type: research
The perfect storm: temporal analysis of air during the world's most deadly epidemic thunderstorm asthma (ETSA) event in Melbourne
CONCLUSION: The findings presented in this article highlight the importance of including ruptured pollen and time-resolved analysis to forecast ETSA events and thus save lives.PMID:37646293 | DOI:10.1177/17534666231186726
Source: Adv Data - August 30, 2023 Category: Epidemiology Authors: Dwan Price Kira M Hughes Dulashi Withanage Dona Philip E Taylor David A V Morton Svetlana Stevanovic Francis Thien Jason Choi Paul Torre Cenk Suphioglu Source Type: research
Research Progress in Nanopharmaceuticals with Different Delivery Routes in the Antivirus Field
Curr Pharm Des. 2023 Aug 30. doi: 10.2174/1381612829666230830105817. Online ahead of print.ABSTRACTHuman health is significantly threatened by infectious diseases caused by viral infection. Over the years, there have been numerous virus epidemics worldwide, causing millions of deaths. Traditional antiviral medications have many problems, including poor solubility and antiviral resistance. Additionally, because different drug delivery methods have different biological barriers to overcome, the drug's bioavailability will be significantly affected. Therefore, it is essential that researchers create more effective antiviral d...
Source: Current Pharmaceutical Design - August 30, 2023 Category: Drugs & Pharmacology Authors: Yenong Shi Dongqiong He Xianwei Zhang Mingqing Yuan Xu Liu Source Type: research
Multilocus Microsatellite Analysis of the Molecular Epidemiology of Microsporum canis Isolated in Japan
Med Mycol J. 2023;64(3):63-72. doi: 10.3314/mmj.23-00003.ABSTRACTMicrosporum canis, a major causative agent of zoonotic dermatophytosis, has become prevalent in Japan. Molecular epidemiological surveys using multilocus microsatellite typing (MLMT), a sensitive genotyping tool for fungi, have been conducted to reveal intraspecies polymorphisms of M. canis.The present study utilized MLMT optimized for Japanese strains of M. canis to analyze epidemic trends of fungal infection. Six individual loci were targeted; namely, MS1, 2, 4, 5, 6, and 7. Analysis of data from 1974 through 2022 identified 416 strains, which were sorted i...
Source: Medical Mycology Journal - August 30, 2023 Category: Biology Authors: Takashi Mochizuki Taketoshi Futatsuya Kazushi Anzawa Shigeo Yamada Kiminobu Takeda Junko Watanabe Andrea Marie Bernales Mendoza Akira Shimizu Source Type: research
The perfect storm: temporal analysis of air during the world's most deadly epidemic thunderstorm asthma (ETSA) event in Melbourne
CONCLUSION: The findings presented in this article highlight the importance of including ruptured pollen and time-resolved analysis to forecast ETSA events and thus save lives.PMID:37646293 | DOI:10.1177/17534666231186726
Source: Respiratory Care - August 30, 2023 Category: Respiratory Medicine Authors: Dwan Price Kira M Hughes Dulashi Withanage Dona Philip E Taylor David A V Morton Svetlana Stevanovic Francis Thien Jason Choi Paul Torre Cenk Suphioglu Source Type: research
