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Infectious Disease: Endemics

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Total 382 results found since Jan 2013.

Vespa velutina nigrithorax venom allergy: inhibition studies approach for the choice of specific immunotherapy
Eur Ann Allergy Clin Immunol. 2022 Dec 13. doi: 10.23822/EurAnnACI.1764-1489.277. Online ahead of print.ABSTRACTVespa velutina nigrithorax (VVN), commonly known as Asian wasp because endemic in Asia, represents an alien species in Europe. VVN can induce allergic reactions similar to those caused by other Hymenoptera and deaths after VVN stings, presumably due to fatal allergic reactions, were reported. In the treatment of Hymenoptera venom hypersensitivity, specific immunotherapy (VIT) is highly effective, and the vaccine allergen-specificity plays a crucial role. Currently, there is no specific available VIT for VVN, so V...
Source: European Annals of Allergy and Clinical Immunology - December 14, 2022 Category: Allergy & Immunology Authors: V Grossi M Severino A Massolo M Infantino F Laureti D Macchia E Meucci E Francescato B Pantera A Ebbli F Fumagalli B Lari A Perri I Liotti G Ciotta G Terenzi S V Valeva M Consolati T Folgore M Manfredi Source Type: research

Galactose-Alpha-1,3-Galactose, Mammalian Meat and Anaphylaxis: A World-Wide Phenomenon?
Opinion Statement Mammalian meat allergy following tick bites is known to occur in Australia, North America, Europe, Asia, Africa and Central America. Over the last decade, the condition has become increasingly prevalent in tick-endemic areas of Australia and the USA. In mammalian meat-allergic individuals, gelatine allergy and/or cow’s milk allergy may co-exist. Awareness of tick-induced allergies in health professionals and the general community is key to both a timely diagnosis and the prevention of mammalian meat allergy. Treatment of mammalian meat allergy is limited currently to avoidance of all mammalian...
Source: Current Treatment Options in Allergy - September 1, 2014 Category: Allergy & Immunology Source Type: research

Component ‐resolved diagnostics demonstrates that most peanut‐allergic individuals could potentially introduce tree nuts to their diet
Conclusions and clinical relevancePR‐10‐sensitizations were frequent and strong regardless of peanut allergy status. Component‐resolved diagnostics can be employed to demonstrate to patients that sensitization to seed storage proteins of tree nuts is uncommon. Several tree nuts could potentially be reintroduced to the diet.
Source: Clinical and Experimental Allergy - February 28, 2018 Category: Allergy & Immunology Authors: R. Uotila, A. K. Kukkonen, W. M. Blom, B. Remington, J. Westerhout, A. S. Pelkonen, M. J. M äkelä Tags: ORIGINAL ARTICLE Source Type: research

The Lake Victoria island intervention study on worms and allergy-related diseases (LaVIISWA): study protocol for a randomised controlled trial
We present the design of the Lake Victoria Island Intervention Study on Worms and Allergy-related diseases (LaVIISWA), a cluster-randomised trial evaluating the risks and benefits of intensive versus standard anthelminthic treatment for allergy-related diseases and other health outcomes.Methods/DesignThe setting is comprised of island fishing communities in Mukono district, Uganda. Twenty-six communities have been randomised in a 1:1 ratio to receive standard or intensive anthelminthic intervention for a three-year period. Baseline characteristics were collected immediately prior to intervention rollout, commenced in Febru...
Source: Trials - April 23, 2015 Category: Journals (General) Authors: Margaret NampijjaEmily WebbJames KaweesaRobert KizindoMilly NamutebiEsther NakazibweGloria OduruProssy KabuubiJoyce KabagenyiDennison KizitoLawrence MuhangiMirriam AkelloJaco VerweijBarbara NerimaEdridah TukahebwaAlison Elliottfor the LaVIISWA trial team Source Type: research

Type-2 innate lymphoid cells in human allergic disease
Purpose of reviewRecent decades have seen allergic diseases become endemic in a number of developed countries. Understanding the inflammatory processes that dictate these allergic responses is therefore important. Recent findingsCritical to many allergic responses is the inappropriate release of the type-2 immune-regulatory cytokines: interleukin-4, interleukin-5, interleukin-9, and interleukin-13. The study of these inflammatory mediators has led directly to the development of two new asthma treatments: anti-interleukin-5 and anti-interleukin-13. Until recently, T helper 2 cells were considered to be the major cellular so...
Source: Current Opinion in Allergy and Clinical Immunology - October 1, 2014 Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Catherine Laprise and Emmanuelle Bouzigon Source Type: research

Effective anthelmintic therapy of residents living in endemic area of high prevalence for hookworm and Schistossoma mansoni infections enhances the levels of allergy risk factor anti-Der p1 IgE
In conclusion, effective anthelmintic therapy of subjects from endemic areas with high prevalence of hookworm and S. mansoni infections enhances anti-Der p1 IgE levels.
Source: Results in Immunology - November 6, 2014 Category: Allergy & Immunology Source Type: research

Questions and Answers: Phase 1 Clinical Trial of the NIAID (National Institute of Allergy and Infectious Diseases) Zika Virus Investigational DNA Vaccine
National Institute of Allergy and Infectious Diseases. 08/03/2016 This resource provides seven questions and answers about the National Institute of Allergy and Infectious Diseases (NIAID) ' s testing in a Phase 1/1b human clinical trial of an investigational Zika vaccine developed by scientists at NIAID ' s Vaccine Research Center. The candidate, called the NIAID Zika virus investigational DNA vaccine, is intended to prevent Zika virus disease. If results show a favorable safety profile and immune response, NIAID plans to initiate a Phase 2 trial in Zika-endemic countries in early 2017. (Text)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - August 4, 2016 Category: Global & Universal Authors: The U.S. National Library of Medicine Source Type: news

From the pages of AllergyWatch
For this installment of From the Pages of Allergy Watch, I have selected articles from the July to August issue. The first, reviewed by Dr Lee, suggests that pretreatment with H1 and H2 antihistamines and montelukast can reduce the risk for reaction to coronavirus disease 2019 (COVID-19) vaccination. The second, reviewed by Dr Hernandez-Trujillo, reports data suggesting that alpha-gal allergy can be a problem even in areas not endemic for the lone star tick. The final article, reviewed by Dr Joshi, presented data suggesting that children with more severe atopic dermatitis are more likely to have learning disabilities.
Source: Annals of Allergy, Asthma and Immunology - September 17, 2021 Category: Allergy & Immunology Authors: Stanley Fineman, Gerald B. Lee, Vivian Hernandez-Trujillo, Shyam Joshi Tags: Special Series Source Type: research

Allergen‐hybrids ‐ next generation vaccines for Fagales pollen immunotherapy
ConclusionThe hybrid molecules showed a more efficient uptake and processing by dendritic cells resulting in a modified T cell response. The proteins had a lower IgE‐binding capacity compared to the parental allergens, thus the high safety profile and increased efficacy emphasizes clinical application for the treatment of Fagales multi‐sensitization.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - December 11, 2013 Category: Allergy & Immunology Authors: Ulrike Pichler, Michael Hauser, Heidi Hofer, Martin Himly, Elisabeth Hoflehner, Markus Steiner, Sonja Mutschlechner, Karin Hufnagl, Christof Ebner, Adriano Mari, Peter Briza, Barbara Bohle, Ursula Wiedermann, Fatima Ferreira, Michael Wallner Tags: Original Article‐Allergens Source Type: research

Allergen hybrids – next generation vaccines for Fagales pollen immunotherapy
ConclusionThe hybrid molecules showed a more efficient uptake and processing by dendritic cells resulting in a modified T cell response. The proteins had a lower IgE‐binding capacity compared with the parental allergens, thus the high safety profile and increased efficacy emphasize clinical application for the treatment of Fagales multi‐sensitization.
Source: Clinical and Experimental Allergy - February 22, 2014 Category: Allergy & Immunology Authors: U. Pichler, M. Hauser, H. Hofer, M. Himly, E. Hoflehner, M. Steiner, S. Mutschlechner, K. Hufnagl, C. Ebner, A. Mari, P. Briza, B. Bohle, U. Wiedermann, F. Ferreira, M. Wallner Tags: Original Article Source Type: research

Further studies on the biological activity of hazelnut allergens
Conclusions This work, extending previously published researches, represents a step towards the better understanding of the complexity of hazelnut allergy and provides new data on the biological activity of hazelnut allergens and extracts.
Source: Clinical and Translational Allergy - July 17, 2015 Category: Allergy & Immunology Source Type: research