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Vaccination: Bird Flu (H5N1 Avian Influenza) Vaccine

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Total 27 results found since Jan 2013.

The U.S. Scientist At the Heart of COVID-19 Lab Leak Conspiracies Is Still Trying to Save the World From the Next Pandemic
Ralph Baric stepped onto the auditorium stage at the University of North Carolina, Chapel Hill, and looked out at the sparse audience that had come to hear him speak. On the large projector screen hanging behind him, the following words appeared: How Bad the Next Pandemic Could Be, What Might It Look Like, and Will We be Ready. The date was May 29, 2018. “Well, I have to admit I’m a little worried about giving this talk,” Baric said. “The reason is being labelled a harbinger of doom.” The screen shifted, and images of the four horsemen of the apocalypse—Death, Famine, War, and Plague&mda...
Source: TIME: Health - July 11, 2023 Category: Consumer Health News Authors: Dan Werb Tags: Uncategorized COVID-19 feature freelance Source Type: news

A New Lab-Made COVID-19 Virus Puts Gain-of-Function Research Under the Microscope
On October 14, a team of scientists at Boston University released a pre-print study reporting that they had created a version of SARS-CoV-2 combining two features of different, existing strains that boosted its virulence and transmissibility. Scientists and the public raised questions about the work, which refocused attention on such experiments, and prompted the U.S. government to investigate whether the research followed protocols for these kinds of studies. The concerns surround what is known as gain-of-function studies, in which viruses, bacteria, or other pathogens are created in the lab—either intentionally or ...
Source: TIME: Science - October 27, 2022 Category: Science Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

U.S. weighs crackdown on experiments that could make viruses more dangerous
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Source: ScienceNOW - October 19, 2022 Category: Science Source Type: news

H5N1 Vaccine Readied for a Possible Influenza Pandemic H5N1 Vaccine Readied for a Possible Influenza Pandemic
Adjuvanted H5N1 influenza vaccine has been shown to be highly immunogenic in younger and older adults. It is being developed in light of a possible H5N1 influenza pandemic that could cause global harm.Medscape Medical News
Source: Medscape Allergy Headlines - April 8, 2022 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Trump ’s State of Emergency Is an Admission of Failure by the U.S. Government
President Donald Trump’s declaration of a national emergency is designed to speed federal support to parts of America that are struggling to prepare for a coming surge of COVID-19 cases, unlocking $50 billion in aid, giving hospitals and doctors more freedom to handle a potential tsunami of sick patients and scrambling to make tests available. In a Rose Garden press conference Friday, Trump presented the emergency measures as proof that, “No nation is more prepared or more equipped to face down this crisis.” But for epidemiologists, medical experts and current and former U.S. public health officials, the ...
Source: TIME: Health - March 13, 2020 Category: Consumer Health News Authors: W.J. Hennigan Tags: Uncategorized COVID-19 Source Type: news

First childhood flu helps explain why virus hits some people harder than others
Why are some people better able to fight off the flu than others? Part of the answer, according to a new study, is related to the first flu strain we encounter in childhood.Scientists from UCLA and the University of Arizona have found that people ’s ability to fight off the flu virus is determined not only by the subtypes of flu they have had throughout their lives, but also by the sequence in which they are been infected by the viruses. Their study is published in the open-access journal PLoS Pathogens.The research offers an explanation for why some people fare much worse than others when infected with the same strain...
Source: UCLA Newsroom: Health Sciences - February 4, 2020 Category: Universities & Medical Training Source Type: news

Broadly Protective Influenza Vaccine Comprising a Cocktail of Inactivated Avian Influenza Viruses
There is a great need for broadly protective, “universal” influenza virus vaccines given the antigenic drift and shift of influenza viruses and the variable protective efficacy of the current influenza vaccines. This technology relates to a broadly protective, “universal” influenza vaccine candidate composed of a cocktail of different l ow pathogenicity avian influenza virus subtypes inactivated by betapropiolactone (BPL). Vaccinating animals with BPL-inactivated whole virus vaccine comprising influenza virus strains belonging to four or more different low pathogenicity avian influenza hemagglutinin subtypes, intra...
Source: NIH OTT Licensing Opportunities - December 5, 2019 Category: Research Authors: ajoyprabhu3 Source Type: research

The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology
Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. Introduction Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influen...
Source: Frontiers in cellular and infection microbiology - April 16, 2019 Category: Microbiology Source Type: research

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model
This study was also partly funded by a research contract from GSK. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the funders. Conflict of Interest Statement AG-S, FK, and PP are inventors in patent applications filed and owned b
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Clinical trial testing topical cream plus influenza vaccine in progress
(NIH/National Institute of Allergy and Infectious Diseases) A Phase 1 clinical trial examining whether a topical cream can enhance the immune response conferred by a 'pre-pandemic' influenza vaccine is underway at Baylor College of Medicine, a Vaccine and Treatment Evaluation Unit (VTEU) funded by NIAID. Investigators are evaluating whether imiquimod cream, commonly used to treat genital warts and certain skin cancers, can boost the body's immune response to an H5N1 influenza vaccine. The trial is enrolling 50 healthy adults ages 18-50 years.
Source: EurekAlert! - Infectious and Emerging Diseases - September 5, 2018 Category: Infectious Diseases Source Type: news

NIAID dcientists create 3D structure of 1918 influenza virus-like particles
(NIH/National Institute of Allergy and Infectious Diseases) Virus-like particles (VLPs) are protein-based structures that mimic viruses and bind to antibodies. Because VLPs aren't infectious, they show promise as vaccine platforms for many viral diseases, including influenza. Since details about influenza VLPs are scant, a team of researchers developed a 3D model based on the 1918 H1 pandemic influenza virus. The research, conducted by NIAID scientists, could benefit VLP vaccine projects, targeting a range of viruses from HIV to Ebola and SARS coronavirus.
Source: EurekAlert! - Infectious and Emerging Diseases - July 11, 2018 Category: Infectious Diseases Source Type: news

Stabilized Influenza Hemagglutinin Stem Region Trimers and Uses Thereof
An effective universal influenza vaccine would eliminate the uncertain and costly process of seasonal influenza vaccine development each year. Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) are developing immunogens which elicit neutralizing antibodies to the highly conserved stem region of the influenza viral protein hemagglutinin. By targeting this highly conserved region, which is nearly identical in various strains of influenza virus, these immunogens could train the immune system to defend against a wide variety of influenza strains including pandemic strains derived from animal reser...
Source: NIH OTT Licensing Opportunities - May 15, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Predictive markers for humoral influenza vaccine response in patients with common variable immunodeficiency (CVID)
One-fifth of the patients with CVID vaccinated against pandemic influenza A(H1N1) converted to a ≥ 1:40 titer of specific antibodies against the antigen and selected clinical and immunological predictive markers were identified in this subgroup.
Source: Journal of Allergy and Clinical Immunology - April 17, 2018 Category: Allergy & Immunology Authors: Ann Gardulf, Hassan Abolhassani, Rolf Gustafson, Lars E. Eriksson, Lennart Hammarstr öm Source Type: research