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Allergology in the public health service of the Community of Madrid: current situation and opportunities in the XXI century public health system.
Abstract The high prevalence of allergic diseases and the use of more complex diagnostic techniques and therapeutic options require allergists to be highly trained professionals and health-care organizations to be knowledgeable about available structural and human resources. Updated information is lacking in Spain, and current activity indicators do not reflect complexity. The present article analyzes the situation of allergology in Madrid and proposes improvements where necessary. The heads of the allergy departments of public hospitals in Madrid voluntarily completed a purpose-designed survey. Data on care activ...
Source: Anales del Sistema Sanitario de Navarra - September 1, 2014 Category: Journals (General) Authors: Domínguez-Ortega J, Ruiz Hornillos J, Chivato T, De la Hoz B, Elices A, Iglesias A, Quirce S, Vega F, Rodríguez Mosquera M Tags: An Sist Sanit Navar Source Type: research

Appearances Can Be Deceiving
I was attending a 50th birthday party for a friend of mine, when I struck up a conversation with someone I had never met. The conversation, of course, was with a woman who seemed genuinely interested in my quest to make air travel safer for those with food allergies. I told her how my family often receives dirty looks from other passengers when we pre-board a plane to wipe down the area for nut residue. I discussed how some people have laughed when asked not to open nut containers in the confined environment of an airplane. It is often hard to convey the seriousness of a life-threatening food allergy because it is a mostl...
Source: Healthy Living - The Huffington Post - January 23, 2015 Category: Consumer Health News Source Type: news

DNA methylation and childhood asthma in the inner city
Epigenetic marks are heritable, influenced by the environment, direct the maturation of T lymphocytes, and in mice enhance the development of allergic airway disease. Thus it is important to define epigenetic alterations in asthmatic populations.
Source: Journal of Allergy and Clinical Immunology - March 12, 2015 Category: Allergy & Immunology Authors: Ivana V. Yang, Brent S. Pedersen, Andrew Liu, George T. O'Connor, Stephen J. Teach, Meyer Kattan, Rana Tawil Misiak, Rebecca Gruchalla, Suzanne F. Steinbach, Stanley J. Szefler, Michelle A. Gill, Agustin Calatroni, Gloria David, Corinne E. Hennessy, Eliza Source Type: research

Seasonal risk factors for asthma exacerbations among inner-city children
Asthma exacerbations remain common, even in children and adolescents, despite optimal medical management. Identification of host risk factors for exacerbations is incomplete, particularly for seasonal episodes.
Source: Journal of Allergy and Clinical Immunology - March 19, 2015 Category: Allergy & Immunology Authors: Stephen J. Teach, Peter J. Gergen, Stanley J. Szefler, Herman E. Mitchell, Agustin Calatroni, Jeremy Wildfire, Gordon R. Bloomberg, Carolyn M. Kercsmar, Andrew H. Liu, Melanie M. Makhija, Elizabeth Matsui, Wayne Morgan, George O'Connor, William W. Busse Source Type: research

Genetics in PBC: What Do the “Risk Genes” Teach Us?
Abstract Primary biliary cirrhosis is characterised by a progressive and destructive lymphocytic cholangitis, targeting small intra-hepatic bile ducts. In association with the histologic liver injury, patients characteristically express highly specific auto-antibodies that recognise a conserved epitope of the pyruvate dehydrogenase complex found on the inner membrane of the mitochondria. Family studies demonstrate a clear increased incidence and prevalence of associated autoimmune diseases; and historically, a clear HLA association with disease has been evident. With the use of a high-throughput whole-genome arra...
Source: Clinical Reviews in Allergy and Immunology - April 10, 2015 Category: Allergy & Immunology Source Type: research

Genetics in PSC: What Do the “Risk Genes” Teach Us?
Abstract A role of genetics in primary sclerosing cholangitis (PSC) development is now firmly established. A total of 16 risk genes have been reported at highly robust (“genome-wide”) significance levels, and ongoing efforts suggest that the list will ultimately be considerably longer. Importantly, this genetic risk pool so far accounts for less than 10 % of an estimated overall PSC susceptibility. The relative importance of genetic versus environmental factors (including gene-gene and gene-environment interactions) in remaining aspects of PSC pathogenesis is unknown, and other study designs than genome-wide...
Source: Clinical Reviews in Allergy and Immunology - April 10, 2015 Category: Allergy & Immunology Source Type: research

New teaching tool could help doctors screen for PsA
A new teaching tool based on the acronym mnemonic PSA may help doctors to screen for psoriatic arthritis in patients with psoriasis or a strong family history of it. The tool tells physicians to ask patients whether they are experiencing core features of psoriatic arthritis (PsA). Such features...
Source: Skin and Allergy News - May 1, 2015 Category: Dermatology Tags: SAN Clinical News SAN News SAN Psoriasis RHEUM News RHEUM Psoriatic arthritis RHEUM Spondyloarthropathies IMN News FPN News Source Type: news

Cost of management in epistaxis admission: Impact of patient and hospital characteristics
ConclusionAlthough hospitalization costs are complex and multifactorial, we were able to identify patient and hospital characteristics associated with high costs in the management of epistaxis. Early identification and intervention, combined with implementation of targeted hospital management protocols, may improve outcomes and reduce financial burden. Level of Evidence2C. Laryngoscope, 2015
Source: The Laryngoscope - July 7, 2015 Category: ENT & OMF Authors: Erden Goljo, Rajan Dang, Alfred M. Iloreta, Satish Govindaraj Tags: Allergy/Rhinology Source Type: research

$4.8 million NIH study will teach an old drug to maintain its tricks
(Wayne State University - Office of the Vice President for Research) With the help of a nearly $4.9 million, 5-year grant from the National Institute for Allergy and Infectious Diseases of the National Institutes of Health, Wayne State University School of Medicine researchers are leading a landmark multi-center, international study that will provide essential information to clinicians for use of polymoxin B in critically ill patients where no other treatments will work.
Source: EurekAlert! - Medicine and Health - July 27, 2015 Category: Global & Universal Source Type: news

Are Your Hands Almost Always Cold? You Might Have Raynaud's Syndrome
My hands are cold almost all of the time. I get cold easily and have a hard time staying warm. When I touch someone, I often have to apologize for having "zombie hands." It has nothing to do with metabolism or body fat. I noticed this issue when I was 14. It was the middle of winter and my bestie and I were totally nuts about the Ramones. We went to a club where they were playing and wanted to be first in line (like in the movie "Rock n Roll High School") so we showed up several hours before the doors opened to prove our loyalty. We were wearing dresses and thick tights. It was winter in NY. My friend, who was more petite ...
Source: Healthy Living - The Huffington Post - August 12, 2015 Category: Consumer Health News Source Type: news

Leprosy is teaching us the immunopathogenesis of inflammatory skin disease
Czarnowicki et al1 have reported that severe atopic dermatitis is characterized by expansion of circulating TH2 and TH22, but not TH17, within the skin-homing population. The TH22 subset has been discovered in leprosy, with increased IL-22 in TH2 anergic lepromatous leprosy and decreased IL-22 in TH1 tuberculoid leprosy with intact cell-mediated immunity.2 The increase in IL-22 at the TH2 lepromatous pole corresponds to the increase in IL-22 in TH2 atopic dermatitis versus TH1 psoriasis.1 TH22 is well established in both TH1 psoriasis and TH2 atopic dermatitis.
Source: Journal of Allergy and Clinical Immunology - October 9, 2015 Category: Allergy & Immunology Authors: Tina Rendini, William Levis Tags: Correspondence Source Type: research

Early relapses in patients with highly active multiple sclerosis commenced on fingolimod; the leeds teaching hospital experience
Fingolimod is the much anticipated oral disease modifying treatment for patients with highly active Multiple sclerosis. A total of 42 patients were commenced on Fingolimod from December 2012 to June 2014 in Leeds Hospitals NHS Trust. Four patients discontinued treatment due to patient choice, consecutive severe relapses and hepatotoxicity. No other severe side effects were noted in these 42 patients. A total of ten relapses were seen in nine patients. Of which eight out of ten relapses occurred within the first two months. Of the nine patients who experienced relapses, five (55%) were previously treated with Natalizumab, a...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Weerasinghe, K. C., Shanmugarajah, P., Russell, M., Ford, H. Tags: Immunology (including allergy), Multiple sclerosis Thur 21, Parallel session 5: Therapeutics Source Type: research

Management of suspected encephalitis in a uk teaching hospital
Conclusions Encephalitis is difficult to confirm and eventual differential of suspected cases is wide. The rate of ITU admission and death demonstrates the vulnerabilities of this cohort. While most patients received LP, aciclovir and MRI, there remains room for improvement in timing and completeness of investigations.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Binks, S., Cooper, R., Wood, R., Martin, L. Tags: Immunology (including allergy), HIV/AIDS, Infection (neurology) Thur 21, Parallel session 5: Therapeutics Source Type: research

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations
Short-term targeted treatment can potentially prevent fall asthma exacerbations while limiting therapy exposure.
Source: Journal of Allergy and Clinical Immunology - October 27, 2015 Category: Allergy & Immunology Authors: Stephen J. Teach, Michelle A. Gill, Alkis Togias, Christine A. Sorkness, Samuel J. Arbes, Agustin Calatroni, Jeremy J. Wildfire, Peter J. Gergen, Robyn T. Cohen, Jacqueline A. Pongracic, Carolyn M. Kercsmar, Gurjit K. Khurana Hershey, Rebecca S. Gruchalla Source Type: research

Epidemiology and recurrence rate of pterygium post excision in Ghanaians.
CONCLUSION: The recurrence rate after pterygium excision using bare sclera technique in Ghanaians is high (37%). PMID: 25320400 [PubMed - indexed for MEDLINE]
Source: Ghana Medical Journal - December 12, 2015 Category: African Health Tags: Ghana Med J Source Type: research