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Specialty: Geriatrics
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Total 25 results found since Jan 2013.
HNF4α contributes to glucose formation in aged rat hepatocytes.
This study suggests that the mild hypoxic conditions in response to aging-dependent hepatic structural changes may contribute to the induction of the gluconeogenic enzyme PEPCK through HNF4α protein stabilization.
PMID: 24177414 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - October 29, 2013 Category: Geriatrics Authors: Park EY, Lee CH, Lee EK, Kim JH, Cova A, Lee SK, Cho SC, Kwak CS, Song KY, Park SC, Jun HS, Kim KT Tags: Exp Gerontol Source Type: research
p15(INK4b) regulates cell cycle signaling in hippocampal astrocytes of aged rats.
CONCLUSIONS: These observations suggest p15(INK4b) is expressed at a steady level in neonatal and adult rat hippocampal astrocytes with no effect on cell cycle regulation. Importantly, aged astrocyte cell cycle regulation was significantly affected by high expression levels of p15(INK4b) suggesting a role for p15(INK4b) in cell cycle regulation when it is expressed at high but not moderate or low levels in hippocampal astrocytes.
PMID: 26526028 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - November 2, 2015 Category: Geriatrics Authors: Wang F, Zhang L Tags: Aging Clin Exp Res Source Type: research
Nothobranchius fish: an untapped resource for studying aging-related neurodegeneration.
Authors: Genade T
Abstract
New models in which aging-related neurodegeneration more closely resembling the combination of pathologies that develop in aging humans are needed. The fish Nothobranchius, which naturally develops such pathologies over the course of its short lifespan, is one such model. This review compares the lifespans and pathologies of different Nothobranchius strains to those of current vertebrate models of aging. Furthermore, existing data pertaining to neurodegeneration in these fish is discussed in the context of their reported neuropathologies, along with open questions related to mammalian chr...
Source: Current Aging Science - February 5, 2021 Category: Geriatrics Tags: Curr Aging Sci Source Type: research
p16INK4A mediates age-related changes in mesenchymal stem cells derived from human dental pulp through the DNA damage and stress response
Publication date: November–December 2014 Source:Mechanisms of Ageing and Development, Volumes 141–142 Author(s): Xingmei Feng , Jing Xing , Guijuan Feng , Dan Huang , Xiaohui Lu , Suzhe Liu , Wei Tan , Liren Li , Zhifeng Gu Mesenchymal stem cells derived from human dental pulp (DP-MSCs) are characterized by self-renewal and multi-lineage differentiation, which play important roles in regenerative medicine. Autologous transfers, as non-immunogenic, constitute the safest approach in cellular transplantations. However, their use may be limited by age-related changes. In the study, we compared DP-MSCs isolated from human...
Source: Mechanisms of Ageing and Development - November 3, 2014 Category: Geriatrics Source Type: research
Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis.
In this study, we show for the first time that the protein level of plasminogen activator inhibitor 1 (PAI-1), a protease inhibitor which plays an essential role in the control of fibrinolysis, was significantly increased with age in mouse lung homogenate and lung fibroblasts. Upon bleomycin challenge, old mice experienced augmented PAI-1 induction and lung fibrosis as compared to young mice. Most interestingly, we show that fewer (myo)fibroblasts underwent apoptosis and more (myo)fibroblasts with increased level of PAI-1 accumulated in the lung of old than in young mice after bleomycin challenge. In vitro studies further ...
Source: Experimental Gerontology - November 28, 2014 Category: Geriatrics Authors: Huang WT, Akhter H, Jiang C, MacEwen M, Ding Q, Antony V, Thannickal VJ, Liu RM Tags: Exp Gerontol Source Type: research
Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging
We reported that regulation of retinoid, especially atRA and 9-cis RA, responsive StAR transcription is largely mediated by an LXR-RXR/RAR heterodimeric motif in the mouse StAR promoter. Herein we demonstrate that retinoids are capable of enhancing StAR protein, P-StAR, and steroid production, in granulosa, adrenocortical, glial, and epidermal cells. Whereas transient expression of RARα and RXRα enhanced 9-cis RA-treated StAR gene transcription, silencing of RXRα with siRNA, decreased StAR and steroid levels. An oligonucleotide probe encompassing an LXR-RXR/RAR motif bound to adrenocortical and epidermal keratinocyte NE...
Source: Mechanisms of Ageing and Development - August 22, 2015 Category: Geriatrics Source Type: research
Role of Prion protein in premature senescence of human fibroblasts
Publication date: Available online 8 August 2017 Source:Mechanisms of Ageing and Development Author(s): Emmanuelle Boilan, Virginie Winant, Elise Dumortier, Benaissa ElMoualij, Pascale Quatresooz, Heinz D. Osiewacz, Florence Debacq-Chainiaux, Olivier Toussaint Prion protein (PrP) is essentially known for its capacity to induce neurodegenerative prion diseases in mammals caused by a conformational change in its normal cellular isoform (PrPC) into an infectious and disease-associated misfolded form, called scrapie isoform (PrPSc). Although its sequence is highly conserved, less information is available on its physiological ...
Source: Mechanisms of Ageing and Development - August 9, 2017 Category: Geriatrics Source Type: research
Genome-wide profiling of adult human papillary and reticular fibroblasts identifies ACAN, Col XI α1, and PSG1 as general biomarkers of dermis ageing, and KANK4 as an exemplary effector of papillary fibroblast ageing, related to contractility
Publication date: Available online 18 June 2018 Source:Mechanisms of Ageing and Development Author(s): Valérie Haydont, Véronique Neiveyans, Hélène Zucchi, Nicolas O. Fortunel, Daniel Asselineau Deciphering the characteristics of dermal fibroblasts is critical to further understand skin ageing. We have conducted a genome-wide transcriptomic characterization of papillary (Fp) and reticular (Fr) fibroblasts extracted from human skin samples corresponding to younger and older adult ages. From this screen, biomarkers suitable for the assessment of chronological ageing were identified, and extrapolated to the context of ph...
Source: Mechanisms of Ageing and Development - June 19, 2018 Category: Geriatrics Source Type: research
17 β-estradiol inhibits H2O2-induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy.
In this study, we examined the roles of SIRT3 in 17β-E2-induced autophagy and 17β-E2-mediated inhibition of hydrogen peroxide (H2O2)-induced senescence in Human umbilical vein endothelial cells (HUVEC). Cellular senescence was measured by immunoblot analysis with antibodies against phosphorylated Rb and senescence-associated β-galactosidase staining. Immunoblot analysis with antibodies against LC3 and p62 was performed to determine autophagy flux. Our findings show that 17β-E2 activates SIRT3 promoter and upregulates SIRT3 gene expression in HUVEC cells. siRNA-mediated silencing of SIRT3 gene expression inhibits 17β-E...
Source: Biogerontology - March 13, 2020 Category: Geriatrics Authors: Xiang X, Huang J, Song S, Wang Y, Zeng Y, Wu S, Ruan Y Tags: Biogerontology Source Type: research
Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway.
This study confirmed that glucose restriction can enhance autophagy, inhibit senescence, and enhance proliferation of HUVECs through the AMPK/SIRT1-FOXA3-Beclin1 pathway.
PMID: 32768436 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - August 4, 2020 Category: Geriatrics Authors: Liu Q, Li H, Wang J, Zhong L, Chen X, Zhang R, Wang H Tags: Exp Gerontol Source Type: research
Aging induces abnormal accumulation of A β in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain
Neurobiol Aging. 2021 Jul 5;106:268-281. doi: 10.1016/j.neurobiolaging.2021.06.022. Online ahead of print.ABSTRACTAβ metabolism in the brain is mediated by endocytosis, one part of the intracellular membrane trafficking system. We previously showed that aging attenuates the interaction of dynein with dynactin, which disrupts the endosomal/lysosomal trafficking pathway involved in Aβ metabolism, resulting in intracellular accumulation of Aβ. Several studies have shown that in Alzheimer's disease (AD), intraneuronal accumulation of Aβ precedes extracellular Aβ depositions. However, it is unclear what accounts for this t...
Source: Neurobiology of Aging - July 30, 2021 Category: Geriatrics Authors: Shingo Koinuma Nobuhiro Shimozawa Yasuhiro Yasutomi Nobuyuki Kimura Source Type: research
Changes in AMPK activity induces cellular senescence in human dental follicle cells
This study examined the role of AMPK in inducing senescence in DFCs. During the induction of cellular senescence, AMPK activity was impaired, suggesting a negative impact on senescence induction. In line with this assumption, cellular senescence was induced upon inhibition of AMPK with a specific siRNA. In addition, after this inhibition, autophagy was also inhibited. Moreover, specific inhibition of autophagy promoted cellular senescence. However, inducers of AMPK such as metformin or AICAR surprisingly increased senescence in DFCs. Interestingly, autophagy was impaired after long-term induction of AMPK with AICAR and met...
Source: Experimental Gerontology - December 23, 2022 Category: Geriatrics Authors: Christian Morsczeck Anja Reck Torsten E Reichert Source Type: research
