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Pediatric Allergic Contact Dermatitis: Lessons for Better Care
Publication date: September–October 2015 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 3, Issue 5 Author(s): Alina Goldenberg, Nanette Silverberg, Jonathan I. Silverberg, James Treat, Sharon E. Jacob Allergic contact dermatitis (ACD) is an immune-mediated condition that is likely underrecognized in children. ACD is the result of primary sensitization and secondary elicitation by allergy-provoking haptens. A detailed clinical history and physical examination may yield diagnosis. Patch testing is the criterion standard diagnostic tool for confirming the diagnosis of ACD in both children ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 12, 2015 Category: Allergy & Immunology Source Type: research

Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future
In the past, the development of more effective, safe, convenient, broadly applicable, and easy to manufacture vaccines for allergen-specific immunotherapy (AIT) has been limited by the poor quality of natural allergen extracts. Progress made in the field of molecular allergen characterization has now made it possible to produce defined vaccines for AIT and eventually for preventive allergy vaccination based on recombinant DNA technology and synthetic peptide chemistry. Here we review the characteristics of recombinant and synthetic allergy vaccines that have reached clinical evaluation and discuss how molecular vaccine app...
Source: Journal of Allergy and Clinical Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Rudolf Valenta, Raffaela Campana, Margit Focke-Tejkl, Verena Niederberger Tags: Reviews and feature article Source Type: research

Antimicrobial allergy 'labels drive inappropriate antimicrobial prescribing: lessons for stewardship
Conclusions AALs are common and appear to be associated with higher rates of inappropriate prescribing and increased use of broad-spectrum antimicrobials. Improved accuracy in defining AALs is likely to be important for effective antimicrobial stewardship (AMS), with efforts to ‘de-label’ inappropriate AAL patients a worthwhile feature of future AMS initiatives.
Source: Journal of Antimicrobial Chemotherapy - May 13, 2016 Category: Microbiology Authors: Trubiano, J. A., Chen, C., Cheng, A. C., Grayson, M. L., Slavin, M. A., Thursky, K. A., on behalf of the National Antimicrobial Prescribing Survey (NAPS) Tags: Original research Source Type: research

Individual healthcare plan for allergic children  at school: lessons from a 2015‐2016 school year survey
ConclusionIHP is mainly implemented for FA. Anaphylaxis remains rare in the school setting and FA is often a suspected cause of reaction. Staff training should be improved. Application of the recommendations regarding the content and accessibility of EK and a widespread emergency action plan are needed.This article is protected by copyright. All rights reserved.
Source: Pediatric Allergy and Immunology - September 7, 2017 Category: Allergy & Immunology Authors: Guillaume Pouessel, St épanie Lejeune, Marie‐Pierre Dupond, Annie Renard, Camille Fallot, Antoine Deschildre Tags: Original Source Type: research

Individual healthcare plan for allergic children at school: Lessons from a 2015 ‐2016 school year survey
ConclusionIndividual healthcare plan is mainly implemented for FA. Anaphylaxis remains rare in the school setting, and FA is often a suspected cause of reaction. Staff training should be improved. Application of the recommendations regarding the content and accessibility of EK and a widespread emergency action plan is needed.
Source: Pediatric Allergy and Immunology - October 5, 2017 Category: Allergy & Immunology Authors: Guillaume Pouessel, St épanie Lejeune, Marie‐Pierre Dupond, Annie Renard, Camille Fallot, Antoine Deschildre Tags: ORIGINAL ARTICLE Source Type: research

348 Prevalence of skin allergy and irritation to cosmetics and associated factors in China: Lessons from more than 600,000 patch test case reactions from over 10,000 individual visits
Cosmetics are widely used in our daily life, and are known to be a common cause of skin allergy and irritation. Skin allergic and irritant reactions to cosmetics are routinely tested following a standard patch test protocol as a safety requirement in China. In order to learn the general prevalence of skin allergy and irritation to cosmetics and the associated factors, we have analyzed the data collected during 2011 and 2017 from a main testing center in Shanghai, China. The dataset includes 10178 individual visits (age 19-66), with an average number of 60 patch test case reactions per individual visit.
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: B. Li, Y. Zou, Y. Cheng, W. Hu, J. Krutmann, Y. Tan, S. Wang Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research

Metal allergy in total-joint arthroplasty: Case report and literature review
This report presents both a case and literature review. Patient concerns: A 61-year-old female patient experienced continuous swelling and pain in the right knee joint for 9 months after a right-side total knee arthroplasty (TKA). Diagnoses: We believe this is the case report of metal allergy in TKA. The following were the reasons for this. First, no definite symptoms of infection during revision arthroplasty were observed, but with obvious hyperplasia of synovium. Furthermore, a frozen biopsy revealed an extremely low neutrophil count, which was considered to be caused by chronic inflammation. Second, the results of...
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology
Over the past decade, there have been substantial advances in our understanding about how viral infections regulate asthma. Important lessons have been learned from birth cohort studies examining viral infections and subsequent asthma and from understanding the relationships between host genetics and viral infections, the contributions of respiratory viral infections to patterns of immune development, the impact of environmental exposure on the severity of viral infections, and how the viral genome influences host immune responses to viral infections.
Source: Journal of Allergy and Clinical Immunology - January 7, 2020 Category: Allergy & Immunology Authors: Matthew C. Altman, Avraham Beigelman, Christina Ciaccio, James E. Gern, Peter W. Heymann, Daniel J. Jackson, Joshua L. Kennedy, Kirsten Kloepfer, Robert F. Lemanske, Laurie M. McWilliams, Lyndsey Muehling, Christy Nance, R. Stokes Peebles Tags: Reviews and feature article Source Type: research

The history of mast cell and basophil research – some lessons learnt from the last century
Abstract This year (2013) marks the 50th anniversary of death of Otto Carl Willy Prausnitz (1876–1963) and Heinz Küstner (1897–1963). The two physicians, when working at the Hygiene Institute at the University of Breslau, Germany (Prausnitz was the Head of the Institute), described in 1921 what is still called today the Prausnitz–Küstner or PK reaction showing that allergy could be transferred from the allergic person by transferring serum to a healthy person. Their discovery ended the belief that an anaphylactic/allergic reaction was caused by poisons, but to the contrary showed that the presence of the hypersensi...
Source: Allergy - August 30, 2013 Category: Allergy & Immunology Authors: U. Blank, F. H. Falcone, G. Nilsson Tags: Review Article Source Type: research

A Brief Intervention to Improve Food Allergy Knowledge Among US Pediatricians: Lessons Learned
Source: PEDIATRICS - October 1, 2013 Category: Pediatrics Authors: Sheikh, S. Z., Burks, A. W. Tags: Food Allergy Source Type: research

Randomised controlled trials in child health in developing countries: trends and lessons over 11 years
Using a uniform systematic approach annually, we reviewed 1553 publications from randomised controlled trials in child health in developing countries published between July 2002 and June 2013. There were annual increases in such publications, from 38 in the 12 months to July 2003 to over 200 in each of 2012 and 2013. These trials involved children in 76 developing countries. Studies of nutrition (366 publications, 23.6%) and malaria (336 publications, 21%) predominated. 79% of nutrition trials have been of micronutrients (288 publications), with comparatively few publications related to macronutrient interventions or ...
Source: Archives of Disease in Childhood - June 12, 2014 Category: Pediatrics Authors: Duke, T., Fuller, D. Tags: Clinical trials (epidemiology), Immunology (including allergy), ADC Global child health, TB and other respiratory infections, Travel medicine, Tropical medicine (infectious diseases), Childhood nutrition, Obesity (nutrition), Reproductive medicine, Child Source Type: research

What lessons can be learned about asthma phenotypes in children from cohort studies?
This article is protected by copyright. All rights reserved.
Source: Pediatric Allergy and Immunology - February 1, 2015 Category: Allergy & Immunology Authors: J Just, P Saint Pierre, F Amat, R Gouvis‐Echraghi, N Lambert‐Guillemot, T Guiddir, I Annesi Maesano Tags: Review Source Type: research

Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects
Publication date: March–April 2015 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 3, Issue 2 Author(s): Fanny Legrand , Amy D. Klion The recent explosion in the number of biologic therapies in clinical development for the treatment of eosinophilic disorders is unprecedented. As these agents become available for clinical use, the selection of the most appropriate agent for a given patient will become increasingly complicated. The aims of this review were 2-fold: (1) to present the lessons learned from clinical trials using the first generation of eosinophil-targeted biologics (anti–IL-5 ant...
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 13, 2015 Category: Allergy & Immunology Source Type: research

Motivating Patient Adherence to Allergic Rhinitis Treatments
Abstract Patient nonadherence significantly burdens the treatment of allergic rhinitis (AR). Fewer than half of prescribed doses of intranasal corticosteroid medication are taken. The challenges for immunotherapies are even greater. While sustained treatment for 3 to 5 years is required for full benefit, most patients receiving immunotherapy, either subcutaneous or sublingual, stop treatment within the first year. Although research into interventions to improve AR adherence is lacking, lessons learned from adherence interventions in other chronic health conditions can be applied to AR. Two well-established, over...
Source: Current Allergy and Asthma Reports - May 8, 2015 Category: Allergy & Immunology Source Type: research