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Geoepidemiology of Primary Biliary Cholangitis: Lessons from Switzerland
AbstractNo data on primary biliary cholangitis (PBC) are available in Switzerland. We established a national patient cohort to obtain information on PBC phenotypes and disease course in Switzerland. Local databases in all university hospitals and in two large secondary centers were searched for case finding. In addition, all primary care physicians, gastroenterologists, rheumatologists, and dermatologists were invited to contribute patients from their own medical records. PBC diagnosis was centrally reviewed. Five hundred one PBC patients were identified, 474 were included in data analysis, and 449 of them were enrolled by...
Source: Clinical Reviews in Allergy and Immunology - November 27, 2017 Category: Allergy & Immunology Source Type: research
Inflammatory foreign body reaction caused by resorbable materials used for orbital fractures repair: A case report
In this study, we encountered a 14-year-old boy treated for the orbital fracture by using resorbable plate, in whom inflammatory foreign body reaction was detected. In addition, this patient had repeated history of skin allergy and upper respiratory tract infection.
Diagnoses:
Intraoperative observation showed that the resorbable material near the orbital rim was covered by granulation and inflammatory tissues, without purulent secretions. The histological examination revealed inflammatory foreign body reaction to the resorbable plate.
Interventions:
Debridement was taken to remove the mass on the left lower eyelid. ...
Source: Medicine - December 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Are We What Our Mothers Made Us? Lessons from Epigenetics
Source: Journal of Allergy and Clinical Immunology - December 20, 2017 Category: Allergy & Immunology Authors: Donata Vercelli Source Type: research
Neurologic manifestations in anaphylaxis due to subcutaneous allergy immunotherapy: A case report
Rationale:
Life-threatening anaphylactic shock is a rare (1 in 1 million) but documented occurrence in response to subcutaneous immunotherapy. Immediate administration of Epinephrine (Epi) is critical to save lives in these situations. The current protocol for systemic reactions in immunotherapy is for the prescribing physician to reassess the dosing and schedule as well as the risk:benefit assessment for the therapy and determine whether or not to proceed.
Patient concerns:
The patient revealed concerns regarding the neurologic sequela sustained after undergoinig life-threatening anaphylactic shock.
Diagnosis:
The...
Source: Medicine - May 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Diagnostic challenges of celiac disease in a young child: A case report and a review of the literature
We present the case of a 1-year-old male child, with a history of idiopathic pericardial effusion, admitted in our clinic for severe abdominal bloating, irritability, loss of appetite and intermittent diarrheic stools. The clinical findings were: influenced general status, irritability, distended abdomen, and diffuse abdominal tenderness.
Diagnoses:
The initial laboratory tests revealed anemia, leukocytosis, increased inflammatory biomarkers, high levels of transaminases, and hypoalbuminemia. The stool culture identified an enterocolitis with enteropathogenic Escherichia coli (E. coli).
Interventions:
We initiated an...
Source: Medicine - June 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Same - Day Appointment System Implemented in Health Network
Lessons learned include importance of matching the changing needs of patients, honoring the patient
Source: Pulmonary Medicine News - Doctors Lounge - November 11, 2014 Category: Respiratory Medicine Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Nephrology, Neurology, Nursing, Oncology, Ophthalmology, Orthopedics, ENT, Pediatrics, Psychiatry, Pulmonology Source Type: news
Lessons learned from the study of human inborn errors of innate immunity
Innate immunity contributes to host defense through all cell types and relies on their shared germline genetic background, whereas adaptive immunity operates via only three main cell types, αβ T cells, γδ T cells, and B cells, and relies on their somatic genetic diversification of antigen-specific responses. Human inborn errors of innate immunity often underlie infectious diseases. The range and nature of infections depend on the mutated gene, the deleteriousness of the mutation, a nd other ill-defined factors.
Source: Journal of Allergy and Clinical Immunology - August 1, 2018 Category: Allergy & Immunology Authors: Giorgia Bucciol, Leen Moens, Barbara Bosch, Xavier Bossuyt, Jean-Laurent Casanova, Anne Puel, Isabelle Meyts Source Type: research
Challenges and Benefits of Repurposing Products for Use during a Radiation Public Health Emergency: Lessons Learned from Biological Threats and other Disease Treatments.
This report reviews the information presented, as well as an overview of discussions from the meeting.
PMID: 30160600 [PubMed - as supplied by publisher]
Source: Radiation Research - August 30, 2018 Category: Physics Authors: DiCarlo AL, Cassatt DR, Dowling WE, Esker JL, Hewitt JA, Selivanova OM, Williams MS, Price PW Tags: Radiat Res Source Type: research
Pitfalls of immunotherapy: lessons from a patient with CTLA-4 haploinsufficiency
Daclizumab is a humanized monoclonal antibody that blocks CD25, the high affinity alpha subunit of the interleukin-2 receptor. Daclizumab therapy targets T regulatory cell and activated effector T cell prolife...
Source: Allergy, Asthma and Clinical Immunology - October 22, 2018 Category: Allergy & Immunology Authors: Leisa Rebecca Watson, Charlotte A. Slade, Samar Ojaimi, Sara Barnes, Pasquale Fedele, Prudence Smith, Justine Marum, Sebastian Lunke, Zornitza Stark, Matthew F. Hunter, Vanessa L. Bryant and Michael Sze Yuan Low Tags: Case report Source Type: research
Very early-onset inflammatory bowel disease: an integrated approach
Purpose of review
Immune dysregulation disorders are among the most rapidly growing set of inborn errors of immunity. One particular subset is the category where early-onset inflammatory bowel disease (IBD) is the most common manifestation. These disorders are being increasingly appreciated although there has been minimal effort to articulate a unified approach to their diagnosis and management. This review will cover current thinking and strategies related to diagnosis and management of very early-onset IBD.
Recent findings
There is an expanding set of monogenic causes of early-onset IBD. In many cases, the precise g...
Source: Current Opinion in Allergy and Clinical Immunology - November 2, 2018 Category: Allergy & Immunology Tags: PRIMARY IMMUNE DEFICIENCY DISEASE: Edited by Stephen Jolles and M. Teresa (Maite) de la Morena Source Type: research
Challenges in Assessing the Efficacy of Systemic Corticosteroids for Severe Wheezing Episodes in Preschool Children
This letter addresses the controversial issue of the use of oral corticosteroids during wheezing exacerbations in preschool-aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, discussing lessons learned, and suggesting future directions.
Source: Journal of Allergy and Clinical Immunology - January 17, 2019 Category: Allergy & Immunology Authors: Theresa W. Guilbert, Leonard B. Bacharier, David T. Mauger, Wanda Phipatanakul, Stanley J. Szefler, Susan Boehmer, Avraham Beigelman, Anne M. Fitzpatrick, Daniel J. Jackson, Sachin N. Baxi, Mindy Benson, Carey-Ann D. Burnham, Michael D. Cabana, Mario Cast Source Type: research
Severe acute interstitial nephritis induced by valsartan: A case report
Rationale:
Angiotensin receptor blocker (ARB) can increase serum creatinine or potassium levels in patients with renal insufficiency, renal artery stenosis, heart failure or hypovolemia, but hardly cause severe kidney injury in patients without any risk factors. A case of severe acute interstitial nephritis (AIN) induced by valsartan was reported here.
Patient concerns:
A 62-year-old female with nausea for 1 month and acute deterioration of kidney function for 2 weeks was admitted. She had a history of hypertension for 5 months and had taken valsartan 40 mg daily for 4 months. Although the valsartan had been stopped...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Emerging Triggers of FPIES: Lessons from a Pediatric Cohort of 74 Children in the US
Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE mediated gastrointestinal food-induced allergic disorder occurring predominantly in infants and young children. Common food triggers and the natural history of FPIES vary according to geographic location. It is a serious condition that is still under-recognized, resulting in a delay in diagnosis and appropriate management. FPIES is characterized by delayed onset of repetitive vomiting occurring approximately 1 to 4 hours after food ingestion.
Source: Annals of Allergy, Asthma and Immunology - February 8, 2019 Category: Allergy & Immunology Authors: Andrea C. Blackman, Sara Anvari, Carla M. Davis, Aikaterini Anagnostou Source Type: research
Are We Relying Too Much on Biomarkers and Algorithms? Are We Relying Too Much on Biomarkers and Algorithms?
In the age of biomarker-based risk assessment, oncologist Ravi Parikh gets ' a sobering lesson in what really matters when we talk about prognosis in oncology. 'Medscape Oncology
Source: Medscape Allergy Headlines - March 1, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology Commentary Source Type: news
Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma
AbstractAimsMobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases.MethodsMASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a ...
Source: Clinical and Translational Allergy - March 10, 2019 Category: Allergy & Immunology Source Type: research
