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O-058 PPODA as a mechanically stable and biocompatible coating for endovascular stents and flow diverters
ConclusionPPODA polymer coatings can improve biocompatibility and prevent thrombosis on FDs and stents by pre-coating wires for braiding or post-coating laser-cut stent devices. Future work will compare coating integrity and biocompatibility to established devices (i.e Pipeline Shield® and Fred-X®). Materials like PPODA may provide FDs and stents with a mechanically stable scaffold coating that promotes continuous re-endothelialization over an aneurysm neck, which can eliminate thrombosis and reduce recanalization rates.Abstract O-058 Figure 1SH-PEG-Silane and PPODA bound to a nitinol wire surface. Figure la is an ...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Robertson, S., Merritt, W., Becker, T., Ducruet, A. Tags: SNIS 20th annual meeting oral abstracts Source Type: research
The Covid Pandemic: Broadening the Discourse
Thailand’s COVID-19 response an example of resilience and solidarity: a UN Resident Coordinator’s BlogBy Asoka BandarageCOLOMBO, Sri Lanka, Nov 10 2020 (IPS) SARS-CoV-2, the corona virus that causes COVID-19, has been spreading exponentially across the world over the last ten or so months. As of November 6th, according to the Center for Systems Science at Johns Hopkins University, there have been 49,195,581 cases of COVID-19, including 1,241,031 deaths.
More than a third of the global population has been placed on lockdown. The global economy is experiencing the deepest global recession since World War 2 and massive n...
Source: IPS Inter Press Service - Health - November 10, 2020 Category: International Medicine & Public Health Authors: Asoka Bandarage Tags: Featured Global Headlines Health Human Rights Humanitarian Emergencies Peace TerraViva United Nations Source Type: news
Hundreds of Cruise Ship Passengers Stuck in Cambodia After Coronavirus Case Confirmed
Hundreds of passengers from a cruise ship are stuck in Cambodia while officials test them for a coronavirus after an elderly woman who had disembarked was found to have the virus.
U.S. State Department officials said that 200 Americans remain in Cambodia, waiting to be cleared for travel, including 92 who remain on board the Holland America Line ship the Westerdam. Cambodian officials asked those in hotels in the country not to leave their rooms while further testing is done. According to the cruise line, the first batch of 406 tests were negative, and cleared guests were allowed to travel home.
On Monday, Holland America...
Source: TIME: Health - February 17, 2020 Category: Consumer Health News Authors: Amy Gunia, Hillary Leung and Madeleine Carlisle Tags: Uncategorized COVID-19 onetime overnight Travel Source Type: news
A Passenger Tested Positive for Coronavirus After Hundreds Exited a U.S. Cruise Ship, Sparking Fears the Outbreak Could Further Spread Worldwide
The elderly cruise passenger who tested positive for coronavirus after disembarking from a U.S. cruise ship in Cambodia has raised the specter that other passengers now dispersed around the world could be infected too.
Currently, hundreds of passengers from Holland America Line’s Westerdam are being held back in Cambodia, where the ship was allowed to dock last week after being denied entry to multiple ports following rumors of a possible coronavirus on board—despite assurances from the cruise line that there were no signs of the virus, officially named COVID-19, in any passengers.
After the shipped docked in ...
Source: TIME: Health - February 17, 2020 Category: Consumer Health News Authors: Amy Gunia, Hillary Leung and Madeleine Carlisle Tags: Uncategorized COVID-19 onetime overnight Travel Source Type: news
Passenger Confirmed to Have Coronavirus After Leaving Cruise Ship That Docked in Cambodia
A passenger on a cruise ship that was denied entry from several countries amid concerns about the spread of a deadly coronavirus was confirmed to be infected with the novel coronavirus after she and her husband disembarked when the ship was allowed to dock in Cambodia.
The confirmation of an infection on the ship has raised concerns about the virus’ further spread, and authorities are scrambling to confirm if other passengers might be infected, potentially spreading the virus to countries it has not yet reached.
The 83-year-old American woman, who had been on board the Holland America Line ship the Westerdam, was s...
Source: TIME: Health - February 17, 2020 Category: Consumer Health News Authors: Amy Gunia and Hillary Leung Tags: Uncategorized COVID-19 onetime overnight Travel Source Type: news
Combining Understanding of Immunological Mechanisms and Genetic Variants Toward Development of Personalized Medicine for Psoriasis Patients
Conclusion
Although GWAS contributed insight into the utility of the genotype biomarker to treatment selection, adequately powered prospective studies will be required before clinical application of pharmacogenomics can become a reality. Genotype and phenotype assessment should be facilitated by the availability of detailed molecular analyses and data integration. Careful assessment of prospective GWAS data is essential to integrate findings into the clinical decision-making process, and thereby optimizing the treatment of patients with psoriasis in the future.
Author Contributions
BY, NG, and WY performed the project. ...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research
PARP-14 Promotes Survival of Mammalian α but Not β Pancreatic Cells Following Cytokine Treatment
Conclusion
This study must be seen as a first piece of a puzzle where PARP-14, JNKs and PJ-34 play key roles in the pancreatic microenvironment and provide starting points from which to explore further.
Author Contributions
VS-P conceived the project and designed the experiments together with MP and CD. MR and FD performed molecular experiments as RT-PCR and western analysis. CS and MS performed confocal analysis. FD, NM, and VB performed cytofluorimetric analysis. FD and MC were in charge of cell culture and treatment. FD performed computational and statistical data analysis, together with AT-S. VS-P and FD wrote the p...
Source: Frontiers in Endocrinology - May 2, 2019 Category: Endocrinology Source Type: research
TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes
In conclusion, this study provides a systematic analysis of the expression of TRAIL-Rs in human primary B cells and of their capacity to signal and induce apoptosis. This dataset forms a basis to further study and understand the dysregulation of TRAIL-Rs and TRAIL expression observed in autoimmune diseases. Additionally, it will be important to foresee potential bystander immunomodulation when TRAIL-R agonists are used in cancer treatment.
Introduction
The homeostasis of humoral immunity requires a tight control of generation, survival, activation and maturation of B lymphocytes. Therefore, pro-survival and pro-apo...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research
Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation
This study was carried out in accordance with the recommendations of the National Institutes of Health standards and guidelines for the care and use of experimental animals. The protocol was approved by the Animal Ethics Committee of National Cheng Kung University (IACUC NO. 107272 and 105077).
Author Contributions
J-YW and M-SC designed the study. Y-HW and Y-LL performed the experiments. Y-HW and W-YC analyzed the data. Y-HW, W-YC, and M-SC wrote the manuscript. W-YC and J-YW provided critical technical and scientific guidance and discussion.
Funding
This work was supported by research grant from the Ministry of Scien...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research
Comparison of Three Immunoassays for the Detection of Myositis Specific Antibodies
Conclusion: The data hold promise for advancements in standardization of MSA assays as well as for the potential inclusion of MSA in future classification criteria.
Introduction
Myositis specific (MSA) and myositis associated antibodies (MAA) have been used as an aid in the diagnosis of idiopathic inflammatory myopathies (IIM) for decades (1). Since many of the MSA (e.g., anti-synthetase antibodies), partly depending on the screening dilution, are accompanied by limited sensitivity of the indirect immunofluorescence (IIF) test, this method has limited utility as a screening test for suspected myositis (2–6)...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research
Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid
Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - April 24, 2019 Category: Psychiatry Source Type: research
Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions
World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research
Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis
Conclusion
In this study, after daily HBOT for 6 days, we identified 11 VOCs which could be divided into two PCs. PC1 (inflammation) showed no significant changes over time, PC2 (methyl alkanes) was significantly reduced after daily exposure for 5 days, to approximately 60% after 2 days’ rest. This suggests that daily HBOT does not induce cumulative damage to the pulmonary system of healthy volunteers, but triggers an adaptive response. Additional studies including more treatment sessions, and perhaps additional systemic parameters on radical oxygen scavengers and inflammatory markers, are necessary to substantiate...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research
Insights Into Dolphins' Immunology: Immuno-Phenotypic Study on Mediterranean and Atlantic Stranded Cetaceans
This study was aimed at implementing the knowledge on the immune response in cetaceans stranded along the Italian coastline to provide a baseline useful for assessing the immune status of bottlenose (Tursiops truncatus) and striped (Stenella coeruleoalba) dolphins. In particular, since the Mediterranean Sea is considered a heavily polluted basin, a comparison with animals living in open waters such as the Atlantic Ocean was made. Formalin-fixed, paraffin-embedded spleen, thymus, and lymph node tissues from 16 animals stranded along Italian and 11 cetaceans from the Canary Island shores were sampled within 48 h from death. ...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research
Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells
Discussion
Treg represent a lineage of T cells which play a fundamental role in maintaining humoral tolerance in the periphery. This subset of “suppressor T cells” is identified as FoxP3-expressing CD4+ T cells (16, 17). The unrestrained expression of FoxP3 is essential for the development and function of Treg (4). Accordingly, a disruption of the Foxp3 gene in scurfy mice results in an autoimmune lymphoproliferative disorder with fatal multi-organ inflammation (18). Since the causative mutation occurs in orthologous genes, the scurfy phenotype is indicated as the murine equivalent of the human IPEX sy...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research
