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Infectious Disease: Hepatitis B
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Total 64 results found since Jan 2013.

The search is on for a hepatitis B drug, thanks to a million dollars in NIH grants to SLU
(Saint Louis University) Two grants from the National Institutes of Health will allow Saint Louis University researchers to build on breakthroughs in understanding the hepatitis B virus and begin the search for a drug to cure -- not just halt -- the illness.
Source: EurekAlert! - Medicine and Health - March 25, 2014 Category: Global & Universal Source Type: news

'Friendly' virus repairs damaged liver cells (but only in mice)
Conclusion This study showed it was possible to engineer and inject instructions that transform myofibroblasts into liver cells in mice with liver disease, which is quite a feat. Not all delivery mechanisms, called vectors, worked, but in those that did, the new liver cells looked normal, replaced some of the dying cells, and led to less damage due to collagen build up. Despite the alcoholism-related headline, the mice did not have alcohol-induced liver damage – although this is a major cause of liver damage in people. This study serves to prove this approach is feasible, and was successful in doing this. Researchers wi...
Source: NHS News Feed - June 3, 2016 Category: Consumer Health News Tags: Genetics/stem cells Lifestyle/exercise Medical practice Source Type: news

Impact of an electronic medical record reminder on hepatitis B vaccine initiation and completion rates among insured adults with diabetes mellitus.
CONCLUSIONS: Use of provider reminders is highly effective in increasing both HepB vaccine initiation and series completion rates among adults with diabetes. PMID: 29958736 [PubMed - as supplied by publisher]
Source: Vaccine - June 26, 2018 Category: Allergy & Immunology Authors: Hechter RC, Qian L, Luo Y, Ling Grant DS, Baxter R, Klein NP, Valdez Nunley K, Aukes L, Hogea C, Krishnarajah G, Patterson BJ, Im TM, Tseng HF Tags: Vaccine Source Type: research

Identification of Hepatitis B virus genotype I in Thailand
Journal of Medical Virology,Volume 0, Issue ja, -Not available-.
Source: Journal of Medical Virology - October 23, 2018 Category: Virology Authors: Vera Holzmayer, Robert Hance, Patricia Defechereux, Robert Grant, Mary C Kuhns, Gavin Cloherty, Mary A Rodgers Source Type: research

Residual risk of infection with blood-borne viruses in potential organ donors at increased risk of infection: systematic review and meta-analysis.
CONCLUSIONS: Absolute risks of window period viral infections are low in people from Australian groups at increased risk but with negative viral test results. Accepting organ donations by people at increased risk of infection but with negative viral test results could be considered as a strategy for expanding the donor pool. REGISTRATION: International Prospective Register of Systematic Reviews (PROSPERO), CRD42017069820. PMID: 31489635 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - September 7, 2019 Category: General Medicine Tags: Med J Aust Source Type: research

133 Organizations Ask Congress to Close the Innovation Deficit
Dear Member of Congress: The 133 undersigned national business, higher education, scientific, patient, and other organizations write to strongly urge you to pass an omnibus FY2015 appropriations bill this year that includes increased investments in scientific research and higher education needed to help close our nation's innovation deficit. Members of the Senate and House from both political parties have highlighted the need to address the innovation deficit. Congress has already taken some preliminary steps in this direction. In most instances, individual appropriations bills considered by the House and Senate Appropri...
Source: ActionBioscience - November 12, 2014 Category: Science Authors: Julie Palakovich Carr Source Type: news

Lipidomic Analysis Reveals Serum Alteration of Plasmalogens in Patients Infected With ZIKA Virus
Discussion Our strategy in this study was to compare the serum lipid profile between ZIKV patients and symptomatic controls that presented virus-like symptoms as fever, arthralgia, headache, exanthema, myalgia and pruritus. Retro-orbital pain and fever were the only clinical symptoms that significantly distinguished ZIKV and control groups (Table 1). A recent study by Melo et al. (2017) showed that the differences in metabolic and lipid profiles in serum of ZIKV patients are so pronounced that they can be differentiated from a control group composed of both healthy and symptomatic subjects. Thus, by using symptomatic pati...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II
Conclusions: The results from this large prospective study suggest that ambient air pollution was not associated with death from most nonlung cancers, but associations with kidney, bladder, and colorectal cancer death warrant further investigation. https://doi.org/10.1289/EHP1249 Received: 18 October 2016 Revised: 31 March 2017 Accepted: 31 March 2017 Published: 21 August 2017 Address correspondence to M.C. Turner, McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, 600 Peter Morand Cres., Room 216, Ottawa, Ontario, Canada K1G 3Z7. Telephone: 613-562-5381. Email: mturner@uottawa.ca Suppleme...
Source: EHP Research - August 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Analysis of the screening results of 24040 potential sperm donors in a human sperm bank in Henan Province, China: a 14-year retrospective cohort study
This study was not performed to analyze the effect of lifestyle habits, such as alcohol consumption and cigarette smoking, on the acceptance rate of potential sperm donors.WIDER IMPLICATIONS OF THE FINDINGSOnly a small proportion of potential sperm donors were accepted in this anonymous sperm donor program. New strategies for sperm donor recruitment may be required to improve the acceptance rate. In the future, we may have to target potential sperm donors who are aged  ≤ 35 years and who received higher education in order to improve the acceptance rate.STUDY FUNDING/COMPETING INTEREST(S)This work was supported by t...
Source: Human Reproduction - February 21, 2021 Category: Reproduction Medicine Source Type: research

Delirium and Psychotic Symptoms Associated with Hyperglycemia in a Patient with Poorly controlled Type 2 Diabetes Mellitus
Conclusion Our case presentation should alert clinicians to the possibility of psychopathological changes caused by hyperglycemia in patients with poorly controlled DM2 (outside the setting of a hyperosmolar hyperglycemic state). Psychopathological decompensation in patients with DM can also lead to nonadherence with the OAD treatment regimen, which can then create a vicious cycle of medical and psychiatric illnesses. Increased awareness of a secondary form of delirium and psychotic symptoms elicited by hyperglycemia in the context of poorly controlled DM2 could lead to suitable and timely treatment with antipsychotic medi...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue acute confusional state delirium diabetes hyperglycemia psychosis Source Type: research

Identification of a New HCV Subtype 6xg Among Injection Drug Users in Kachin, Myanmar
This study has several limitations. Frist, HCV exists in a quasispecies form in human body (Martell et al., 1992). It will be better to obtain a single full-length genome sequence from a single virus. However, because of failure in amplification of near full-length HCV genome (>5000 bps), we amplified and sequenced 10 overlapping HCV genomic segments to obtain the whole genome sequence. Therefore, the genomic sequences obtained in this study contain some ambiguous (or degenerate) nucleotides (quasispecies population). Second, previous studies showed that vast majority of IDUs in Yunnan, especially in the China-Myanmar bord...
Source: Frontiers in Microbiology - April 17, 2019 Category: Microbiology Source Type: research

Next-Generation Cancer Immunotherapy Targeting Glypican-3
This study was supported in part by the National Cancer Center Research and Development Fund (25-A-7 and 28-A-8); Health and Labor Science Research Grants for Clinical Research, Japan; and joint research funding from Takeda Pharmaceutical Co, Ltd.; Noile-Immune Biotech Inc.; Ono Pharmaceutical Co., Ltd.; BrightPath Biotherapeutics Co., Ltd.; and Sysmex Co., Ltd. This study was performed as part of a research program of the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct), Ministry of Education, Culture, Sports, Science and Technology of Japan. Conflict of Interest Statement TN, TS, and TY ...
Source: Frontiers in Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

FDA grants Breakthrough Device Designation for Roche ' s Elecsys GALAD score to support earlier diagnosis of hepatocellular carcinoma
Basel, 4 March 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Device Designation to the Elecsys ® GALAD score.* This algorithmic score combines gender and age with the biomarker results of the Elecsys AFP, AFP-L3 and PIVKA-II and is intended to aid diagnosis of early stage hepatocellular carcinoma (HCC). Dr. Amit Singal, Medical Director of the Liver Tumor Program   and Clinical Chief of Pathology at UT Southwestern Medical Center in Dallas, USA, stated, " HCC is the fourth leading cause of cancer-related death worldwide, with the highes...
Source: Roche Investor Update - March 4, 2020 Category: Pharmaceuticals Source Type: news