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Drug: Lithium

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Effects of lithium, valproic acid, carbamazepine and antipsychotic agents on cognition in bipolar disorders-A systematic review
CONCLUSION: Lithium should be recommended for the long-term treatment of bipolar disorder. Valproic acid should not or carefully be used as it can affect the risk of developing dementia. With respect to antipsychotics there is no recommendation as more studies are needed to evaluate the long-term consequences.PMID:36922444 | DOI:10.1007/s00115-023-01454-y
Source: Der Nervenarzt - March 16, 2023 Category: Neurology Authors: Sophie Leopold Arnim Quante Source Type: research

Neuropsychological Functioning and Temperament Traits in a Czech Sample of Children and Adolescents at Familial Risk of Bipolar Disorder
Conclusions: Neuropsychological impairment does not seem to be a trait marker of BD in the premorbid stage. Temperament with low effortful control and low attention focusing might be associated with the development of mood disorders in BO. Introduction Children of parents with bipolar disorder (BD), i.e., bipolar offspring (BO), have an increased risk of developing the disorder than offspring of mentally healthy parents (control offspring; CO), with an estimated heritability of 59% (1). The clinical staging model for BD was developed to improve early interventions and to prevent its onset (2, 3). BO with no symptoms ...
Source: Frontiers in Psychiatry - April 8, 2019 Category: Psychiatry Source Type: research

Lithium Disilicate Restorations Fatigue Testing Parameters: A Systematic Review
ConclusionThe studies reviewed showed a level of heterogeneity, as testing parameters were considered through different setups. The current study demonstrated that various setting of the testing parameters and having a lack of testing standardization has likely led to inconsistency in the reported results. The obvious heterogeneity in the setting of testing variables—especially the magnitude of load and number of cycles applied—made it impractical to run direct comparisons between the reviewed studies. Therefore, specific international standardization of fatigue testing of dental restorations is urgently needed to ensu...
Source: Journal of Prosthodontics - October 27, 2015 Category: Dentistry Authors: Noor Nawafleh, Muhanad Hatamleh, Shareen Elshiyab, Florian Mack Tags: Review Source Type: research

Transcriptome Changes in Relation to Manic Episode
This study was supported by the National Health Research Institutes Project (NHRI-EX106-10627NI), Ministry of Science and Technology Project (MOST 105-2628-B-002-028-MY3), and the National Taiwan University Career Development Project (104R7883) to PI, Dr. PH Kuo, and MOST 107-2314-b-038-085 to PI, Dr. CH Chen, and Taipei City Hospital Research Project (TPCH-108-057) to PI, Dr. MC Huang.Conflict of Interest StatementThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.AcknowledgmentsA part of data analysis ...
Source: Frontiers in Psychiatry - April 30, 2019 Category: Psychiatry Source Type: research

Zeolites as Carriers of Antitumor Ribonuclease Binase
In this study we tested the clinoptilolite, chabazite, and natrolite ability to be loaded by antitumor ribonuclease binase and the cytotoxicity of the obtained complexes. We found the optimal conditions for binase loading into zeolites and established the dynamic of its release. Cytotoxic effects of zeolite-binase complexes toward colorectal cancer Caco2 cells were characterized after 24 and 48 h of incubation with cells using MTT-test. Zeolites were toxic by itselfs and reduced cells viability by 30% (clinoptilolite), 40% (chabazite), and 70% (natrolite) after 48 h of incubation. Binase complexes with clinoptilolite as we...
Source: Frontiers in Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

News at a glance: U.S. rules on carbon emissions, better vehicle batteries, and a Mars moon ’s close-up
PLANETARY SCIENCE Mars’s moon may be its kin Researchers have long believed that Mars’s two moons, Deimos and Phobos, are captured asteroids. But the first close-up images of Deimos, taken by the United Arab Emirates’s $200 million Hope spacecraft, suggest the 12-kilometer-wide body instead formed from the same material as Mars, researchers revealed this week at the annual meeting of the European Geosciences Union. The imagery, taken during a 10 March flyby, indicates that Deimos’s surface is covered by volcanic basalts like those on Mars, with no signs of the carbon-rich rock more often found on ast...
Source: ScienceNOW - April 27, 2023 Category: Science Source Type: news

Lithium for schizophrenia.
CONCLUSIONS: The evidence base for the use of lithium in schizophrenia is limited to 22 studies of overall low methodological quality. There is no randomised trial-based evidence that lithium on its own is an effective treatment for people with schizophrenia. There is some GRADE low quality evidence that augmentation of antipsychotics with lithium is effective, but the effects are not significant when more prone-to-bias open RCTs are excluded. Nevertheless, further large and well-designed trials are justified. These should concentrate on two target groups: (1) people with no affective symptoms, so that trialists can determ...
Source: Cochrane Database of Systematic Reviews - October 28, 2015 Category: Journals (General) Authors: Leucht S, Helfer B, Dold M, Kissling W, McGrath JJ Tags: Cochrane Database Syst Rev Source Type: research

Probing and Quantifying Cathode Charge Heterogeneity in Li Ion Batteries
J. Mater. Chem. A, 2019, Accepted Manuscript DOI: 10.1039/C9TA06977A, Review ArticleYuxin Zhang, Zhijie Yang, Chixia Tian Increasing the energy density and cycle life has been a continuing effort to improve lithium ion batteries. Beyond designing new materials, improving the utilization of current materials is a critical... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - August 30, 2019 Category: Chemistry Authors: Yuxin Zhang Source Type: research

A Combination of Olanzapine and Samidorphan in Adults with Schizophrenia and Bipolar I Disorder: Overview of Clinical Data
CONCLUSION: Data across 18 OLZ/SAM studies in >1600 subjects support an antipsychotic efficacy and safety profile for OLZ/SAM that is similar to olanzapine, with significantly less weight gain than olanzapine. OLZ/SAM is a potential new treatment for schizophrenia and BD-I patients needing efficacious long-term treatment with reduced risk of weight gain.FUNDING: Alkermes, Inc.PMID:34127121 | DOI:10.1017/S1092852920002771
Source: CNS Spectrums - June 15, 2021 Category: Neurology Authors: Leslie Citrome Christine Graham Adam Simmons Ying Jiang Mark S Todtenkopf Bernard L Silverman Lauren DiPetrillo Hannah Cummings Lei Sun David McDonnell Source Type: research