Transcriptome Changes in Relation to Manic Episode
We reported DEGs with a nominal p-value of 0.8. The network construction was created using blockwiseModules function for consideration of computer efficiency. The module detection criteria were as follows: minimum module size of 50, deepsplit of 4, and merge threshold of 0.25. The merged modules were then summarized with module eigengene (ME) correlations>0.75. MEs were defined by their first principal component and were labeled with different colors as module names in the Results section. After the modules were generated, we conducted different enrichment analysis to explore the functional interpretation of genes within the modules.Moreover, we conducted enrichment analysis with genome-wide association (GWA) signals for BD. We downloaded the summary statistics results from one of the latest GWA study of BD from the Psychiatric Genomic Consortium from BioRxiv (8). We used loci with significant level less than a p-value of 5*10−6 and reannotated them with Ensembl database (35). In total, we obtained 131 genes, including coding and noncoding genes for the GWA enrichment analysis. There were, in total, 137 DEGs that showed signals in both our discovery samples and mega-analysis. We thus conducted DEG enrichment analysis to explore whether the mania-related modules are more enriched with these DEG signals. The p-value of each module for enrichment analyses was calculated using Fisher’s exact test. Lastly, for modules significantly associated with mania status or YM...
Thousands of Covid-19 patients have been treated with blood plasma outside of rigorous clinical trials — hampering research that would have shown whether the therapy worked.
This study compared stroke characteristics and poststroke care and disability between these groups.Stroke
Vaccines protecting against influenza, hepatitis B and rabies are less effective for obese people. As scientists develop a Covid-19 vaccine, experts say obesity could be an impediment, a sobering prospect for the US, where nearly half of all adults are obese.
Stacey Nagy told CNN's Erin Burnett she wrote an obituary for her husband's coronavirus death where she blamed President Trump, Texas Gov. Abbott and those who do not wear masks because she felt a need to "put blame where it belonged."
The U.S. says Health and Human Services Secretary Alex Azar will visit Taiwan in the coming days
In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure-activity relationship was analyzed to disclose the crucial sub-structures for the potent activity. PMID: 32741921 [PubMed - in process]
In this study, we investigated the potential effects of disocin on amyloid-β peptide (Aβ1-42) oligomers-treated HT22 cells. Aβ1-42 oligomers induced great neurotoxicity to HT22 cells as examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results of terminal deoxynucleoitidyl transferase-mediated deoxyuridine triphosphate biotin nich end labeling (TUNEL) staining and flow cytometry indicated that Aβ1-42 oligomers led to increased apoptosis and generation of reactive oxygen species (ROS) in HT22 cells. However, dioscin could remarkably inhibit the neurotoxicity induce...
This article summarizes the up-to-date information regarding the phytochemistry, pharmacology, processing, toxicity and safety of Rou Cong Rong to reveal its pharmacodynamic basis and potential therapeutic effects, which could be of great value for its use in future research. PMID: 32741910 [PubMed - in process]
Advice and information on how to look after your mental health and wellbeing during the coronavirus (COVID-19) outbreak. Update in this version (published 4th August 2020) - added translated documents in Arabic, Bengali, Chinese CN, Chinese HK, French, Gujarati, Polish, Portuguese, Punjabi and Urdu.
This is advice for parents and carers on looking after the mental health and wellbeing of children or young people during the coronavirus (COVID-19) outbreak. Update in this version (published 4th August 2020) - added translated documents in: Arabic, Bengali, Chinese CN, Chinese HK, French, Gujarati, Polish, Portuguese, Punjabi and Urdu.
More News: Academia | ADHD | Alzheimer's | Anxiety | Asthma | Austria Health | Biology | Biotechnology | Bipolar | Brain | Brain Cancers | Brain Tumor | Calcium | Cancer | Cancer & Oncology | Cancer in Adolescents | Carcinoma | Cardiology | Cardiovascular | Career Development | Child Development | Children | China Health | Computers | Concerta | Databases & Libraries | Deep Brain Stimulation | Depression | Disability | Eating Disorders & Weight Management | Environmental Health | Epidemiology | France Health | Funding | Generalized Anxiety Disorder (GAD) | Genetics | Geodon | Germany Health | Glioma | Heart | Heart Attack | Herbs | Hospitals | Hyperactivity | International Medicine & Public Health | Japan Health | Lithium | Mania | Medical Ethics | Men | Methylphenidate | Molecular Biology | Neurology | Neuroscience | Neurosurgery | Obesity | Parkinson's Disease | Psychiatry | Reproduction Medicine | Risperdal Consta | Ritalin | Schizophrenia | Science | Seroquel | Sleep Disorders | Sleep Medicine | Sodium | Statistics | Stem Cell Therapy | Stem Cells | Study | Taiwan Health | Thyroid | Thyroid Cancer | Training | Universities & Medical Training | USA Health | Ziprasidone | Zyprexa