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Drug: Ciprofloxacin

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Total 6685 results found since Jan 2013.

Assessment of bacteriological quality of ready to eat food vended in streets of Silchar city, Assam, India
I Sharma, JA MazumdarIndian Journal of Medical Microbiology 2014 32(2):169-171A total of 37 street vended food samples were examined for bacterial and the colony forming units counts ranged from 4.5 × 10 5 to 1.12 × 10 6 . The isolates were identified as Escherichia coli (37.5%), Pseudomonas aeruginosa (3.57%), Staphylococcus aureus (14.20%), Salmonella sp. (5.36%), Klebsiella sp. (10.71%), Shigella sp. (19.64%) and Enterobacter sp. (8.93%) respectively. All the 56 isolates were susceptible to ciprofloxacin while their susceptibility to the other drug...
Source: Indian Journal of Medical Microbiology - April 2, 2014 Category: Microbiology Authors: I SharmaJA Mazumdar Source Type: research

Drug resistance of clinical and environmental isolates of Brucella species in Iran: a meta-analysis
Conclusion: Our study revealed that the prevalence of drug resistance of Brucella species isolated from clinical and environmental samples in Iran was acceptable and low. However, care should be exercised in the use of common antibiotics for the treatment of brucellosis to prevent the spread of drug resistance.
Source: Reviews in Medical Microbiology - October 1, 2018 Category: Microbiology Tags: Bacteriology Source Type: research

Ciprofloxacin and risk of hypolycemia in non-diabetic patients
ConclusionsThis assessment found a suggestive causal link between use of ciprofloxacin and hypoglycemia in patients without diabetes.
Source: Journal of Medical Case Reports - May 11, 2019 Category: General Medicine Source Type: research

Ciprofloxacin and risk of hypoglycemia in non-diabetic patients
ConclusionsThis assessment found a suggestive causal link between use of ciprofloxacin and hypoglycemia in patients without diabetes.
Source: Journal of Medical Case Reports - May 11, 2019 Category: General Medicine Source Type: research

The search of potential inhibitors of the AcrAB-TolC system of multidrug-resistant Escherichia coli: an in silico approach.
Abstract The number of infections caused by multidrug antibiotic resistance (MDR) species is increasing globally. The efflux pump system, AcrAB-TolC, confers Escherichia coli resistance to many antibiotics and results in poor treatment outcomes. Different rational drug design techniques were employed to search for a safe and effective AcrAB-TolC system inhibitor. Ligand docking was performed to analyze the binding of different ArcB substrates and/or inhibitors in the different AcrAB crystal structure binding sites. The validated docking site using the established docking preferences was used to perform virtual hig...
Source: Applied Microbiology and Biotechnology - June 16, 2019 Category: Microbiology Authors: Abdel-Halim H, Al Dajani A, Abdelhalim A, Abdelmalek S Tags: Appl Microbiol Biotechnol Source Type: research

Group A Streptococcus Antibiotic Resistance in Iranian Children: A Meta-analysis.
Conclusions: Our findings suggest penicillin (in non-allergic children) and macrolides, lincosamides, and narrow-spectrum cephalosporins (in penicillin-allergic children) as the treatments of choice in Iran. PMID: 33585043 [PubMed]
Source: Oman Medical Journal - February 17, 2021 Category: Middle East Health Tags: Oman Med J Source Type: research

Concurrent and transferable resistance to extended-spectrum cephalosporins, monobactam and fluoroquinolone in a Salmonella enterica serovar Worthington blood isolate from a neonate in Kolkata, India
Non-typhoidal Salmonella (NTS) infection, characterised by gastroenteritis with or without focal extraintestinal invasion, represents a major public health problem in developing countries. Emergence of NTS isolates resistant both to extended-spectrum cephalosporins (ESCs) and fluoroquinolones (FQs), the current drugs of choice for invasive NTS infections, is a challenge to the treatment of these infections . In NTS, FQ resistance is mainly mediated by mutations in the quinolone resistance-determining regions of DNA gyrase and topoisomerase; in addition, the role of plasmids and efflux pumps has been investigated . Resistan...
Source: International Journal of Antimicrobial Agents - March 4, 2013 Category: Drugs & Pharmacology Authors: Priyanka Jain, Subhasree Roy, Rajlakshmi Viswanathan, Sulagna Basu, Arun K. Singh, Shanta Dutta Tags: Letters to the Editor Source Type: research

Epidemiological and Clinical Features of Salmonella Typhi Infection Among Adult Patients in Qatar: A Hospital-based Study.
Conclusions: Typhoid fever was frequent among immigrants to endemic areas. Travelers returning from endemic areas with suspected typhoid fever should be treated empirically with third-generation cephalosporin after obtaining appropriate cultures. Moreover, preventive measurements such as education on food and water hygiene, and effective vaccination of travelers should be practiced widely among travelers to endemic areas to reduce morbidity and mortality. PMID: 30410688 [PubMed]
Source: Oman Medical Journal - November 11, 2018 Category: Middle East Health Tags: Oman Med J Source Type: research

Investigation of oxacillinases type beta-lactamases in carbapenems resistant Acinetobacter baumannii clinical isolates
This study aimed to identify the carbapenem resistant A. baumannii isolates in ICU and analyse OXA-23, OXA-24, OXA-51 and OXA-58 genes’ expressions by using reverse transcritptase-PCR. In this study, A. baumannii isolates collected from the respiratory tract samples obtained from the patients receiving treatment between June 2017 and January 2018 at the ICU in Amasya University Sabuncuoğlu Serefeddin Education and Research Hospital. Collected samples identified by VITEK-2 device. Resistance profiles of carbapenem-resistant strains against to cefepime, ceftazidime, ciprofloxacin, levofloxacin, amikacin, gentamicin, tetra...
Source: Reviews in Medical Microbiology - October 1, 2020 Category: Microbiology Tags: BACTERIOLOGY Source Type: research

Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids.
Abstract A series of 1,2,4-triazole-based compounds was designed as potential antibacterial agents using molecular hybridization approach. The target compounds (23-44) were synthesized by Mannich reaction of 1,2,4-triazole-3-thione derivatives with ciprofloxacin (CPX) and formaldehyde. Their potent antibacterial effect on Gram-positive bacteria was accompanied by similarly strong activity against Gram-negative strains. The toxicity of the CPX-triazole hybrids for bacterial cells was even up to 18930 times higher than the toxicity for human cells. The results of enzymatic studies showed that the antibacterial activ...
Source: European Journal of Medicinal Chemistry - April 29, 2015 Category: Chemistry Authors: Plech T, Kaproń B, Paneth A, Kosikowska U, Malm A, Strzelczyk A, Stączek P, Świątek Ł, Rajtar B, Polz-Dacewicz M Tags: Eur J Med Chem Source Type: research

Topological pattern for the search of new active drugs against methicillin resistant Staphylococcus aureus.
Abstract Molecular topology was used to develop a mathematical model capable of classifying compounds according to antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA). Topological indices were used as structural descriptors and their relation to antimicrobial activity was determined by using linear discriminant analysis. This topological model establishes new structure activity relationships which show that the presence of cyclopropyl, chlorine and ramification pairs at a distance of two bonds favor this activity, while the presence of tertiary amines decreases it. This model was appl...
Source: European Journal of Medicinal Chemistry - July 8, 2017 Category: Chemistry Authors: Bueso-Bordils JI, Perez-Gracia MT, Suay-Garcia B, Duart MJ, Martin Algarra RV, Lahuerta Zamora L, Anton-Fos GM, Aleman Lopez PA Tags: Eur J Med Chem Source Type: research

From quinoline to quinazoline-based S. aureus NorA efflux pump inhibitors by coupling focused scaffold hopping approach and pharmacophore search
ChemMedChem. 2021 May 25. doi: 10.1002/cmdc.202100282. Online ahead of print.ABSTRACTAntibiotic resistance breakers, such as efflux pump inhibitors (EPIs), represent a powerful alternative to the development of new antimicrobials. Recently, by using previously described EPIs, we developed pharmacophore models able to identify inhibitors of NorA, the most studied efflux pump of the Staphylococcus aureus. Herein, we reported a pharmacophore-based virtual screening of a library of new potential NorA EPIs generated by an in-silico scaffold hopping approach of the quinoline core. After chemical synthesis and biological evaluati...
Source: ChemMedChem - May 25, 2021 Category: Chemistry Authors: Nicholas Cedraro Rolando Cannalire Andrea Astolfi Gianmarco Mangiaterra Tommaso Felicetti Salvatore Vaiasicca Giada Cernicchi Serena Massari Giuseppe Manfroni Oriana Tabarrini Violetta Cecchetti Maria Letizia Barreca Francesca Biavasco Stefano Sabatini Source Type: research

Search for a Shared Genetic or Biochemical Basis for Biofilm Tolerance to Antibiotics across Bacterial Species
Antimicrob Agents Chemother. 2022 Mar 10:e0002122. doi: 10.1128/aac.00021-22. Online ahead of print.ABSTRACTIs there a universal genetically programmed defense providing tolerance to antibiotics when bacteria grow as biofilms? A comparison between biofilms of three different bacterial species by transcriptomic and metabolomic approaches uncovered no evidence of one. Single-species biofilms of three bacterial species (Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii) were grown in vitro for 3 days and then challenged with respective antibiotics (ciprofloxacin, daptomycin, and tigecycline) for an ad...
Source: Antimicrobial Agents and Chemotherapy - March 10, 2022 Category: Microbiology Authors: Philip S Stewart Kerry S Williamson Laura Boegli Timothy Hamerly Ben White Liam Scott Xiao Hu Brendan M Mumey Michael J Franklin Brian Bothner Francisco G Vital-Lopez Anders Wallqvist Garth A James Source Type: research