Concurrent and transferable resistance to extended-spectrum cephalosporins, monobactam and fluoroquinolone in a Salmonella enterica serovar Worthington blood isolate from a neonate in Kolkata, India

Non-typhoidal Salmonella (NTS) infection, characterised by gastroenteritis with or without focal extraintestinal invasion, represents a major public health problem in developing countries. Emergence of NTS isolates resistant both to extended-spectrum cephalosporins (ESCs) and fluoroquinolones (FQs), the current drugs of choice for invasive NTS infections, is a challenge to the treatment of these infections . In NTS, FQ resistance is mainly mediated by mutations in the quinolone resistance-determining regions of DNA gyrase and topoisomerase; in addition, the role of plasmids and efflux pumps has been investigated . Resistance to ESCs and monobactams by production of extended-spectrum β-lactamases (ESBLs) such as TEM, SHV and CTX-M has also been reported . The genes encoding these enzymes are usually carried on mobile elements such as conjugative plasmids, transposons or integrons, thus increasing the possibility of transfer of antimicrobial resistance to other organisms. Here we report transferable concurrent resistance to ESCs, monobactam and ciprofloxacin in a Salmonella enterica serovar Worthington (S. Worthington) blood isolate from a 4-day-old neonate admitted to the neonatal intensive care unit (NICU) of the Institute of Post Graduate Medical Education & Research (IPGMER), a tertiary care hospital in Kolkata, India.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Letters to the Editor Source Type: research